Skip Nav Destination
Issues
1 December 2017
-
Cover Image
Cover Image
8-Oxo7,8-dihydro-2′-deoxyguanosine (8-oxodG), an oxidized form of deoxyguanosine, is a major product of DNA oxidation and is used as a biomarker for oxidative stress in cancer. The level of 8-oxodG in cellular DNA reflects the balance between the rate of DNA damage and the efficiency of DNA repair. This merged image of double fluorescent-labeled murine xenografted human kidney cancer cells shows a high abundance of 8-oxodG (stained green with FITC) within the nuclei (identified by red propidium iodide staining of all DNA). A higher level of orange to green staining within the kidney tumor section as compared with the normal kidney (not shown) indicates more oxidative DNA damage within the tumor. The image was taken using a Nikon research microscope equipped for epifluorescence with excitation and band pass filters. For details, see article by Abu Aboud and colleagues on page 6746.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Molecular and Cellular Pathobiology
Author Choice
Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel
Rui Xie; Jingyu Xu; Yufeng Xiao; Jilin Wu; Hanxing Wan; Bo Tang; Jingjing Liu; Yahan Fan; Suming Wang; Yuyun Wu; Tobias Xiao Dong; Michael X. Zhu; John M. Carethers; Hui Dong; Shiming Yang
Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Rona Yaeger; Zhan Yao; David M. Hyman; Jaclyn F. Hechtman; Efsevia Vakiani; HuiYong Zhao; Wenjing Su; Lu Wang; Andrew Joelson; Andrea Cercek; Jose Baselga; Elisa de Stanchina; Leonard Saltz; Michael F. Berger; David B. Solit; Neal Rosen
Author Choice
Loss of FOXO1 Cooperates with TMPRSS2–ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion
Yinhui Yang; Alexandra M. Blee; Dejie Wang; Jian An; Yunqian Pan; Yuqian Yan; Tao Ma; Yundong He; Joseph Dugdale; Xiaonan Hou; Jun Zhang; S. John Weroha; Wei-Guo Zhu; Y. Alan Wang; Ronald A. DePinho; Wanhai Xu; Haojie Huang
Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks
Dylan Z. Kelley; Emily L. Flam; Evgeny Izumchenko; Ludmila V. Danilova; Hildegard A. Wulf; Theresa Guo; Dzov A. Singman; Bahman Afsari; Alyza M. Skaist; Michael Considine; Jane A. Welch; Elena Stavrovskaya; Justin A. Bishop; William H. Westra; Zubair Khan; Wayne M. Koch; David Sidransky; Sarah J. Wheelan; Joseph A. Califano; Alexander V. Favorov; Elana J. Fertig; Daria A. Gaykalova
Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Barbara R. Tschida; Nuri A. Temiz; Timothy P. Kuka; Lindsey A. Lee; Jesse D. Riordan; Carlos A. Tierrablanca; Robert Hullsiek; Sandra Wagner; Wendy A. Hudson; Michael A. Linden; Khalid Amin; Pauline J. Beckmann; Rachel A. Heuer; Aaron L. Sarver; Ju Dong Yang; Lewis R. Roberts; Joseph H. Nadeau; Adam J. Dupuy; Vincent W. Keng; David A. Largaespada
Tumor and Stem Cell Biology
JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia
Maria De Grandis; Florence Bardin; Cyril Fauriat; Christophe Zemmour; Abdessamad El-Kaoutari; Arnauld Sergé; Samuel Granjeaud; Laurent Pouyet; Camille Montersino; Anne-Sophie Chretien; Marie-Joelle Mozziconacci; Remy Castellano; Ghislain Bidaut; Jean-Marie Boher; Yves Collette; Stéphane J.C. Mancini; Norbert Vey; Michel Aurrand-Lions
Therapeutics, Targets, and Chemical Biology
EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming
Remi Adelaiye-Ogala; Justin Budka; Nur P. Damayanti; Justine Arrington; Mary Ferris; Chuan-Chih Hsu; Sreenivasulu Chintala; Ashley Orillion; Kiersten Marie Miles; Li Shen; May Elbanna; Eric Ciamporcero; Sreevani Arisa; Piergiorgio Pettazzoni; Giulio F. Draetta; Mukund Seshadri; Bradley Hancock; Milan Radovich; Janaiah Kota; Michael Buck; Heike Keilhack; Brian P. McCarthy; Scott A. Persohn; Paul R. Territo; Yong Zang; Joseph Irudayaraj; W. Andy Tao; Peter Hollenhorst; Roberto Pili
Microenvironment and Immunology
Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target
Jacob New; Levi Arnold; Megha Ananth; Sameer Alvi; Mackenzie Thornton; Lauryn Werner; Ossama Tawfik; Hongying Dai; Yelizaveta Shnayder; Kiran Kakarala; Terance T. Tsue; Douglas A. Girod; Wen-Xing Ding; Shrikant Anant; Sufi Mary Thomas
Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA–MUF Interaction with ANXA2 and miR-34a
Xinlong Yan; Dongdong Zhang; Wei Wu; Shuheng Wu; Jingfeng Qian; Yajing Hao; Fang Yan; Pingping Zhu; Jiayi Wu; Guanling Huang; Yinghui Huang; Jianjun Luo; Xinhui Liu; Benyu Liu; Xiaomin Chen; Ying Du; Runsheng Chen; Zusen Fan
Integrated Systems and Technologies
Prevention and Epidemiology
Corrections
Advertisement