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Volume 77, Issue 20
15 October 2017
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    The double staining of intracytoplasmic cytoskeleton cytokeratins and cleaved caspase-3 is a useful methodology to visualize cell death–related processes in tumors. Using immunofluorescence and confocal microscopy acquisition, it was found that treatment of EL-4 thymoma-bearing mice with a humanized antibody that recognizes Jagged 1 and 2 results in the coexpression of pan-cytokeratin (yellow) and cleaved caspase-3 (red) in the tumor. For details, see article by Sierra and colleagues on page 5628.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Cancer Self-Defense: An Immune Stealth
Kosei Nakajima; Pratima Nangia-Makker; Victor Hogan; Avraham Raz
View articletitled, Cancer Self-Defense: An Immune Stealth
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The Rac GTPase in Cancer: From Old Concepts to New Paradigms
Marcelo G. Kazanietz; Maria J. Caloca
View articletitled, The Rac GTPase in Cancer: From Old Concepts to New Paradigms
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Molecular and Cellular Pathobiology

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Kate Vandyke; Mara N. Zeissig; Duncan R. Hewett; Sally K. Martin; Krzysztof M. Mrozik; Chee Man Cheong; Peter Diamond; L. Bik To; Stan Gronthos; Daniel J. Peet; Peter I. Croucher; Andrew C.W. Zannettino
View articletitled, HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary data
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Author Choice
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Lin Jin; Trung Vu; Guandou Yuan; Pran K. Datta
View articletitled, STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Supplementary data
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LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression
Yi Liang; Musaddeque Ahmed; Haiyang Guo; Fraser Soares; Junjie T. Hua; Shuai Gao; Catherine Lu; Christine Poon; Wanting Han; Jens Langstein; Muhammad B. Ekram; Brian Li; Elai Davicioni; Mandeep Takhar; Nicholas Erho; R. Jeffrey Karnes; Dianne Chadwick; Theodorus van der Kwast; Paul C. Boutros; Cheryl H. Arrowsmith; Felix Y. Feng; Anthony M. Joshua; Amina Zoubeidi; Changmeng Cai; Housheng H. He
View articletitled, LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression
Supplementary data
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Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis
Lisa M. Julian; Sean P. Delaney; Ying Wang; Alexander A. Goldberg; Carole Doré; Julien Yockell-Lelièvre; Roger Y. Tam; Krinio Giannikou; Fiona McMurray; Molly S. Shoichet; Mary-Ellen Harper; Elizabeth P. Henske; David J. Kwiatkowski; Thomas N. Darling; Joel Moss; Arnold S. Kristof; William L. Stanford
View articletitled, Human Pluripotent Stem Cell–Derived <em>TSC2</em>-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis
Supplementary data
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Tumor and Stem Cell Biology

De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Saber Tadros; Surendra K. Shukla; Ryan J. King; Venugopal Gunda; Enza Vernucci; Jaime Abrego; Nina V. Chaika; Fang Yu; Audrey J. Lazenby; Lyudmyla Berim; Jean Grem; Aaron R. Sasson; Pankaj K. Singh
View articletitled, <em>De Novo</em> Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Supplementary data
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Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma
Eunjee Lee; Margaret Pain; Huaien Wang; Jacob A. Herman; Chad M. Toledo; Jennifer G. DeLuca; Raymund L. Yong; Patrick Paddison; Jun Zhu
View articletitled, Sensitivity to <em>BUB1B</em> Inhibition Defines an Alternative Classification of Glioblastoma
Supplementary data
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Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells
Zharko Daniloski; Susan Smith
View articletitled, Loss of Tumor Suppressor <em>STAG2</em> Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells
Supplementary data
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Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1
Fan Yang; Jun Wei; Song Zhang; Xiaobo Zhang
View articletitled, Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1
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Therapeutics, Targets, and Chemical Biology

Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies
J. Kyle Bruner; Hayley S. Ma; Li Li; Alice Can Ran Qin; Michelle A. Rudek; Richard J. Jones; Mark J. Levis; Keith W. Pratz; Christine A. Pratilas; Donald Small
View articletitled, Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies
Supplementary data
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Author Choice
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer
Lingyan Jin; Jesse Garcia; Emily Chan; Cecile de la Cruz; Ehud Segal; Mark Merchant; Samir Kharbanda; Ryan Raisner; Peter M. Haverty; Zora Modrusan; Justin Ly; Edna Choo; Susan Kaufman; Maureen H. Beresini; F. Anthony Romero; Steven Magnuson; Karen E. Gascoigne
View articletitled, Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer
Supplementary data
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ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Lukas Perkhofer; Anna Schmitt; Maria Carolina Romero Carrasco; Michaela Ihle; Stephanie Hampp; Dietrich Alexander Ruess; Elisabeth Hessmann; Ronan Russell; André Lechel; Ninel Azoitei; Qiong Lin; Stefan Liebau; Meike Hohwieler; Hanibal Bohnenberger; Marina Lesina; Hana Algül; Laura Gieldon; Evelin Schröck; Jochen Gaedcke; Martin Wagner; Lisa Wiesmüller; Bence Sipos; Thomas Seufferlein; Hans Christian Reinhardt; Pierre-Olivier Frappart; Alexander Kleger
View articletitled, ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Supplementary data
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Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter
Valéry L. Payen; Myriam Y. Hsu; Kristin S. Rädecke; Elisabeth Wyart; Thibaut Vazeille; Caroline Bouzin; Paolo E. Porporato; Pierre Sonveaux
View articletitled, Monocarboxylate Transporter MCT1 Promotes Tumor Metastasis Independently of Its Activity as a Lactate Transporter
Supplementary data
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Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors
Yuechao Zhao; Mary J. Laws; Valeria Sanabria Guillen; Yvonne Ziegler; Jian Min; Abhishek Sharma; Sung Hoon Kim; David Chu; Ben Ho Park; Steffi Oesterreich; Chengjian Mao; David J. Shapiro; Kendall W. Nettles; John A. Katzenellenbogen; Benita S. Katzenellenbogen
View articletitled, Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors
Supplementary data
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Author Choice
Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors
Fabio Conforti; Xu Zhang; Guanhua Rao; Tommaso De Pas; Yoko Yonemori; Jose Antonio Rodriguez; Justine N. McCutcheon; Raneen Rahhal; Anna T. Alberobello; Yisong Wang; Yu-Wen Zhang; Udayan Guha; Giuseppe Giaccone
View articletitled, Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors
Supplementary data
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Microenvironment and Immunology

Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Rosa A. Sierra; Jimena Trillo-Tinoco; Eslam Mohamed; Lolie Yu; Bhagelu R. Achyut; Ali Arbab; Jennifer W. Bradford; Barbara A. Osborne; Lucio Miele; Paulo C. Rodriguez
View articletitled, Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Supplementary data
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Author Choice
β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy
Mark J. Bucsek; Guanxi Qiao; Cameron R. MacDonald; Thejaswini Giridharan; Lauren Evans; Brian Niedzwecki; Haichao Liu; Kathleen M. Kokolus; Jason W.-L. Eng; Michelle N. Messmer; Kristopher Attwood; Scott I. Abrams; Bonnie L. Hylander; Elizabeth A. Repasky
View articletitled, β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8<sup>+</sup> T Cells and Undermines Checkpoint Inhibitor Therapy
Supplementary data
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CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy
Martin Turcotte; David Allard; Deepak Mittal; Yacine Bareche; Laurence Buisseret; Vinu José; Sandra Pommey; Vincent Delisle; Sherene Loi; Heikki Joensuu; Pirkko-Liisa Kellokumpu-Lehtinen; Christos Sotiriou; Mark J. Smyth; John Stagg
View articletitled, CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy
Supplementary data
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GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity
Frank Cichocki; Bahram Valamehr; Ryan Bjordahl; Bin Zhang; Betsy Rezner; Paul Rogers; Svetlana Gaidarova; Stacey Moreno; Katie Tuininga; Phillip Dougherty; Valarie McCullar; Peter Howard; Dhifaf Sarhan; Emily Taras; Heinrich Schlums; Stewart Abbot; Daniel Shoemaker; Yenan T. Bryceson; Bruce R. Blazar; Scott Wolchko; Sarah Cooley; Jeffrey S. Miller
View articletitled, GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity
Supplementary data
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T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia
Weiqing Jing; Jill A. Gershan; Sandra Holzhauer; James Weber; Katie Palen; Laura McOlash; Kirthi Pulakanti; Erin Wesley; Sridhar Rao; Bryon D. Johnson; Matthew J. Riese
View articletitled, T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia
Supplementary data
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Clinical Studies

Author Choice
Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer
Howard I. Scher; Ryon P. Graf; Nicole A. Schreiber; Brigit McLaughlin; Adam Jendrisak; Yipeng Wang; Jerry Lee; Stephanie Greene; Rachel Krupa; David Lu; Pascal Bamford; Jessica E. Louw; Lyndsey Dugan; Hebert A. Vargas; Martin Fleisher; Mark Landers; Glenn Heller; Ryan Dittamore
View articletitled, Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer
Supplementary data
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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