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Volume 77, Issue 2
15 January 2017
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    Epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with myeloid leukemia, but not in normal donors. Therefore, EpCAM has the potential to serve as an effective therapeutic target in leukemia. In a myeloid leukemia xenograft model, the mice were treated with anti-EpCAM antibody or IgG for 3 weeks. Immunofluorescence staining for intratumor apoptotic leukemia cells (TUNEL positive, green) was increased in tumors treated with anti-EpCAM antibody. Nuclei were stained with DAPI (blue). For details, see article by Zheng and colleagues on page 482.
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ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

The RAS–Effector Interaction as a Drug Target
Adam B. Keeton; E. Alan Salter; Gary A. Piazza
View articletitled, The RAS–Effector Interaction as a Drug Target
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Author Choice
Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer
Carl Koschmann; Felipe J. Nunez; Flor Mendez; Jacqueline A. Brosnan-Cashman; Alan K. Meeker; Pedro R. Lowenstein; Maria G. Castro
View articletitled, Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer
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Meeting Report

A Conference of New Ideas in Cancer—Challenging Dogmas
Varsha Gandhi; Rakesh Jalali
View articletitled, A Conference of New Ideas in Cancer—Challenging Dogmas
Supplementary data
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Integrated Systems and Technologies

Author Choice
Quantitative Fluorescence Microscopy Measures Vascular Pore Size in Primary and Metastatic Brain Tumors
Rajendar K. Mittapalli; Chris E. Adkins; Kaci. A. Bohn; Afroz S. Mohammad; Julie A. Lockman; Paul R. Lockman
View articletitled, Quantitative Fluorescence Microscopy Measures Vascular Pore Size in Primary and Metastatic Brain Tumors
Supplementary data
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Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer
Santosh Kumar Paidi; Asif Rizwan; Chao Zheng; Menglin Cheng; Kristine Glunde; Ishan Barman
View articletitled, Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer
Supplementary data
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A Novel Platinum(II)–Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F–Conjugated Trastuzumab
Niels J. Sijbrandi; Eugen Merkul; Joey A. Muns; Dennis C.J. Waalboer; Kevin Adamzek; Marije Bolijn; Veronica Montserrat; Govert W. Somsen; Rob Haselberg; Paul J.G.M. Steverink; Hendrik-Jan Houthoff; Guus A.M.S. van Dongen
View articletitled, A Novel Platinum(II)–Based Bifunctional ADC Linker Benchmarked Using <sup>89</sup>Zr-Desferal and Auristatin F–Conjugated Trastuzumab
Supplementary data
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Microenvironment and Immunology

Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone
Caroline Reynaud; Laura Ferreras; Paola Di Mauro; Casina Kan; Martine Croset; Edith Bonnelye; Floriane Pez; Clémence Thomas; Géraldine Aimond; Antoine E. Karnoub; Marie Brevet; Philippe Clézardin
View articletitled, Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone
Supplementary data
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Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Ran Li; Jess D. Hebert; Tara A. Lee; Hao Xing; Alexandra Boussommier-Calleja; Richard O. Hynes; Douglas A. Lauffenburger; Roger D. Kamm
View articletitled, Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Supplementary data
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Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells
Ibrahim M. Sektioglu; Rafael Carretero; Nadja Bulbuc; Tobias Bald; Thomas Tüting; Alexander Y. Rudensky; Günter J. Hämmerling
View articletitled, Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8<sup>+</sup> T Cells
Supplementary data
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Author Choice
MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia
Amina M. Abdul-Aziz; Manar S. Shafat; Tarang K. Mehta; Federica Di Palma; Matthew J. Lawes; Stuart A. Rushworth; Kristian M. Bowles
View articletitled, MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia
Supplementary data
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PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Roxanne Charlebois; Bertrand Allard; David Allard; Laurence Buisseret; Martin Turcotte; Sandra Pommey; Pavel Chrobak; John Stagg
View articletitled, PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Supplementary data
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Molecular and Cellular Pathobiology

IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis
Mihir Rajurkar; Kyvan Dang; Maite G. Fernandez-Barrena; Xiangfan Liu; Martin E. Fernandez-Zapico; Brian C. Lewis; Junhao Mao
View articletitled, IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis
Supplementary data
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Author Choice
KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Yu Gao; Hongzhao Li; Xin Ma; Yang Fan; Dong Ni; Yu Zhang; Qingbo Huang; Kan Liu; Xintao Li; Lei Wang; Liangyou Gu; Yuanxin Yao; Qing Ai; Qingshan Du; Erlin Song; Xu Zhang
View articletitled, KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplementary data
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Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF
Su Yeon Han; Aram Ko; Haruhisa Kitano; Chel Hun Choi; Min-Sik Lee; Jinho Seo; Junya Fukuoka; Soo-Youl Kim; Stephen M. Hewitt; Joon-Yong Chung; Jaewhan Song
View articletitled, Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF
Supplementary data
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Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation
Sophie Bernichtein; Natascha Pigat; Nicolas Barry Delongchamps; Florence Boutillon; Virginie Verkarre; Philippe Camparo; Edouard Reyes-Gomez; Arnaud Méjean; Stéphane M. Oudard; Eve M. Lepicard; Mélanie Viltard; Jean-Claude Souberbielle; Gérard Friedlander; Thierry Capiod; Vincent Goffin
View articletitled, Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation
Supplementary data
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Author Choice
ZIC5 Drives Melanoma Aggressiveness by PDGFD-Mediated Activation of FAK and STAT3
Reiko Satow; Tomomi Nakamura; Chiaki Kato; Miku Endo; Mana Tamura; Ryosuke Batori; Shiori Tomura; Yumi Murayama; Kiyoko Fukami
View articletitled, ZIC5 Drives Melanoma Aggressiveness by PDGFD-Mediated Activation of FAK and STAT3
Supplementary data
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Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer
Étienne Audet-Walsh; Tracey Yee; Shawn McGuirk; Mathieu Vernier; Carlo Ouellet; Julie St-Pierre; Vincent Giguère
View articletitled, Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer
Supplementary data
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Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Ling-Wen Ding; Qiao-Yang Sun; Kar-Tong Tan; Wenwen Chien; Anand Mayakonda Thippeswamy; Allen Eng Juh Yeoh; Norihiko Kawamata; Yasunobu Nagata; Jin-Fen Xiao; Xin-Yi Loh; De-Chen Lin; Manoj Garg; Yan-Yi Jiang; Liang Xu; Su-Lin Lim; Li-Zhen Liu; Vikas Madan; Masashi Sanada; Lucia Torres Fernández; Hema Preethi; Michael Lill; Hagop M. Kantarjian; Steven M. Kornblau; Satoru Miyano; Der-Cherng Liang; Seishi Ogawa; Lee-Yung Shih; Henry Yang; H. Phillip Koeffler
View articletitled, Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia
Supplementary data
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Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase
Zijie Feng; Lei Wang; Yanmei Sun; Zongzhe Jiang; John Domsic; Chiying An; Bowen Xing; Jingjing Tian; Xiuheng Liu; David C. Metz; Xiaolu Yang; Ronen Marmorstein; Xiaosong Ma; Xianxin Hua
View articletitled, Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase
Supplementary data
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Author Choice
Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer
Ka-wing Fong; Jonathan C. Zhao; Jung Kim; Shangze Li; Yeqing A. Yang; Bing Song; Laure Rittie; Ming Hu; Ximing Yang; Bernard Perbal; Jindan Yu
View articletitled, Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer
Supplementary data
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Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Yanxia Shi; Albert Steppi; Ye Cao; Jianan Wang; Max M. He; Liren Li; Jinfeng Zhang
View articletitled, Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine
Supplementary data
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Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton
Karineh Kazazian; Christopher Go; Hannah Wu; Olga Brashavitskaya; Roland Xu; James W. Dennis; Anne-Claude Gingras; Carol J. Swallow
View articletitled, Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton
Supplementary data
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Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer
Mo Li; Qian Chen; Xiaochun Yu
View articletitled, Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer
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Therapeutics, Targets, and Chemical Biology

Author Choice
Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Samira Jaeger; Ana Igea; Rodrigo Arroyo; Victor Alcalde; Begoña Canovas; Modesto Orozco; Angel R. Nebreda; Patrick Aloy
View articletitled, Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Supplementary data
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Transcriptional Selectivity of Epigenetic Therapy in Cancer
Takahiro Sato; Matteo Cesaroni; Woonbok Chung; Shoghag Panjarian; Anthony Tran; Jozef Madzo; Yasuyuki Okamoto; Hanghang Zhang; Xiaowei Chen; Jaroslav Jelinek; Jean-Pierre J. Issa
View articletitled, Transcriptional Selectivity of Epigenetic Therapy in Cancer
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EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Xiaohu Zheng; Xiaolei Fan; Binqing Fu; Meijuan Zheng; Aimei Zhang; Kai Zhong; Jialai Yan; Rui Sun; Zhigang Tian; Haiming Wei
View articletitled, EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
Supplementary data
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Author Choice
Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA
Tong-You Wade Wei; Pei-Yu Wu; Ting-Jung Wu; Hsin-An Hou; Wen-Chien Chou; Chieh-Lin Jerry Teng; Chih-Ru Lin; Jo-Mei Maureen Chen; Ting-Yang Lin; Hsiang-Chun Su; Chia-Chi Flora Huang; Chang-Tze Ricky Yu; Shih-Lan Hsu; Hwei-Fang Tien; Ming-Daw Tsai
View articletitled, Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA
Supplementary data
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Author Choice
Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra
Juliann Chmielecki; Mark Bailey; Jie He; Julia Elvin; Jo-Anne Vergilio; Shakti Ramkissoon; James Suh; Garrett M. Frampton; James X. Sun; Samantha Morley; Daniel Spritz; Siraj Ali; Laurie Gay; Rachel L. Erlich; Jeffrey S. Ross; Joana Buxhaku; Hilary Davies; Vinny Faso; Alexis Germain; Blair Glanville; Vincent A. Miller; Philip J. Stephens; Katherine A. Janeway; John M. Maris; Soheil Meshinchi; Trevor J. Pugh; Jack F. Shern; Doron Lipson
View articletitled, Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra
Supplementary data
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Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment
Yang Liu; Srilakshmi Pandeswara; Vinh Dao; Álvaro Padrón; Justin M. Drerup; Shunhua Lao; Aijie Liu; Vincent Hurez; Tyler J. Curiel
View articletitled, Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment
Supplementary data
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Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma
Qingming Tang; Bo Cheng; Mengru Xie; Yatao Chen; Jiajia Zhao; Xin Zhou; Lili Chen
View articletitled, Circadian Clock Gene <em>Bmal1</em> Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma
Supplementary data
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Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Tomohiro Shibata; Kosuke Watari; Hiroto Izumi; Akihiko Kawahara; Satoshi Hattori; Chihiro Fukumitsu; Yuichi Murakami; Ryuji Takahashi; Uhi Toh; Ken-ichi Ito; Shigehiro Ohdo; Maki Tanaka; Masayoshi Kage; Michihiko Kuwano; Mayumi Ono
View articletitled, Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Supplementary data
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A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Antoine Azan; Peter J. Caspers; Tom C. Bakker Schut; Séverine Roy; Céline Boutros; Christine Mateus; Emilie Routier; Benjamin Besse; David Planchard; Atmane Seck; Nyam Kamsu Kom; Gorana Tomasic; Senada Koljenović; Vincent Noordhoek Hegt; Matthieu Texier; Emilie Lanoy; Alexander M.M. Eggermont; Angelo Paci; Caroline Robert; Gerwin J. Puppels; Lluis M. Mir
View articletitled, A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
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Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer
Vikram B. Wali; Casey G. Langdon; Matthew A. Held; James T. Platt; Gauri A. Patwardhan; Anton Safonov; Bilge Aktas; Lajos Pusztai; David F. Stern; Christos Hatzis
View articletitled, Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer
Supplementary data
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Tumor and Stem Cell Biology

SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor
Li-Sheng Zheng; Jun-Ping Yang; Yun Cao; Li-Xia Peng; Rui Sun; Ping Xie; Meng-Yao Wang; Dong-Fang Meng; Dong-Hua Luo; Xiong Zou; Ming-Yuan Chen; Hai-Qiang Mai; Ling Guo; Xiang Guo; Jian-Yong Shao; Bi-Jun Huang; Wei Zhang; Chao-Nan Qian
View articletitled, SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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