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1 August 2017
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Mesenchymal carcinoma cells recruit immunosuppressive Tregs and M2 macrophages to the tumor microenvironment relative to their epithelial counterparts, which recruit cytotoxic CD8+ T cells instead. In carcinomas that are comprised of heterogeneous mixtures of both epithelial and mesenchymal cells, minority subpopulations of immunosuppressive mesenchymal carcinoma cells are able to protect the entire tumor, including its epithelial cells, from immune attack. Immunofluorescence analysis of mixed tumor sections revealed that mesenchymal (green) and epithelial (white) carcinoma cells segregate to distinct sectors of the tumor. F480+ macrophages (red) are interspersed only among the mesenchymal cells of the tumor, while only a few scattered macrophages are found at the periphery of epithelial sectors within the same tumor. For details, see article by Dongre and colleagues on page 3982.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Priority Report
Molecular and Cellular Pathobiology
IGFBP7 Deletion Promotes Hepatocellular Carcinoma
Maaged Akiel; Chunqing Guo; Xia Li; Devaraja Rajasekaran; Rachel G. Mendoza; Chadia L. Robertson; Nidhi Jariwala; Fang Yuan; Mark A. Subler; Jolene Windle; Dawn K. Garcia; Zhao Lai; Hung-I Harry Chen; Yidong Chen; Shah Giashuddin; Paul B. Fisher; Xiang-Yang Wang; Devanand Sarkar
Tumor and Stem Cell Biology
Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer
Johanna Kondelin; Alexandra E. Gylfe; Sofie Lundgren; Tomas Tanskanen; Jiri Hamberg; Mervi Aavikko; Kimmo Palin; Heikki Ristolainen; Riku Katainen; Eevi Kaasinen; Minna Taipale; Jussi Taipale; Laura Renkonen-Sinisalo; Heikki Järvinen; Jan Böhm; Jukka-Pekka Mecklin; Pia Vahteristo; Sari Tuupanen; Lauri A. Aaltonen; Esa Pitkänen
Therapeutics, Targets, and Chemical Biology
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity
Kensuke Tateishi; Fumi Higuchi; Julie J. Miller; Mara V.A. Koerner; Nina Lelic; Ganesh M. Shankar; Shota Tanaka; David E. Fisher; Tracy T. Batchelor; A. John Iafrate; Hiroaki Wakimoto; Andrew S. Chi; Daniel P. Cahill
Microenvironment and Immunology
Author Choice
Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition
Rasha Abu Eid; Shamim Ahmad; Yuan Lin; Mason Webb; Zuzana Berrong; Rajeev Shrimali; Takumi Kumai; Sudha Ananth; Paulo C. Rodriguez; Esteban Celis; John Janik; Mikayel Mkrtichyan; Samir N. Khleif
Author Choice
Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy
Laetitia Fend; Takahiro Yamazaki; Christelle Remy; Catherine Fahrner; Murielle Gantzer; Virginie Nourtier; Xavier Préville; Eric Quéméneur; Oliver Kepp; Julien Adam; Aurélien Marabelle; Jonathan M. Pitt; Guido Kroemer; Laurence Zitvogel
An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer
Justin A. Kenkel; William W. Tseng; Matthew G. Davidson; Lorna L. Tolentino; Okmi Choi; Nupur Bhattacharya; E. Scott Seeley; Daniel A. Winer; Nathan E. Reticker-Flynn; Edgar G. Engleman
Integrated Systems and Technologies
3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy
Huaming Yan; Mónica Romero-López; Lesly I. Benitez; Kaijun Di; Hermann B. Frieboes; Christopher C.W. Hughes; Daniela A. Bota; John S. Lowengrub
Prevention and Epidemiology
Risk of Second Malignancies in Solid Organ Transplant Recipients Who Develop Keratinocyte Cancers
Rachel D. Zamoiski; Elizabeth Yanik; Todd M. Gibson; Elizabeth K. Cahoon; Margaret M. Madeleine; Charles F. Lynch; Sally Gustafson; Marc T. Goodman; Melissa Skeans; Ajay K. Israni; Eric A. Engels; Lindsay M. Morton
Correction
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