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1 July 2017
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Immunometabolism is emerging as a critical determinant of cancer pathophysiology. A balance between tumor promotion and elimination is dependent on the state of functional polarization of macrophage populations within the tumor microenvironment. Lactic acid generated by lactate dehydrogenase-A is a key metabolite that facilities the immunosuppressive tumor microenvironment. Deletion of lactate dehydrogenase-A in myeloid cells restores the immunocompetent tumor microenvironment by reversing macrophage phenotype and antitumor immunity. Immunofluorescence staining revealed an increased number of infiltrating inducible nitric oxide synthase-positive (red) and M1-skewed F4.80-positive (green) macrophages in K-Ras tumors after deletion of lactate dehydrogenase-A. For details, see article by Seth and colleagues on page 3632.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Obituary
Meeting Report
Molecular and Cellular Pathobiology
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK–LKB1 Signaling Axis
Mathew C. Casimiro; Gabriele Di Sante; Agnese Di Rocco; Emanuele Loro; Claudia Pupo; Timothy G. Pestell; Sara Bisetto; Marco A. Velasco-Velázquez; Xuanmao Jiao; Zhiping Li; Christine M. Kusminski; Erin L. Seifert; Chenguang Wang; Daniel Ly; Bin Zheng; Che-Hung Shen; Philipp E. Scherer; Richard G. Pestell
Tumor and Stem Cell Biology
Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer
Steve Paltoglou; Rajdeep Das; Scott L. Townley; Theresa E. Hickey; Gerard A. Tarulli; Isabel Coutinho; Rayzel Fernandes; Adrienne R. Hanson; Iza Denis; Jason S. Carroll; Scott M. Dehm; Ganesh V. Raj; Stephen R. Plymate; Wayne D. Tilley; Luke A. Selth
Author Choice
Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
Jorge Barbazán; Lorena Alonso-Alconada; Nadia Elkhatib; Sara Geraldo; Vasily Gurchenkov; Alexandros Glentis; Guillaume van Niel; Roberta Palmulli; Beatriz Fernández; Patricia Viaño; Tomas Garcia-Caballero; Rafael López-López; Miguel Abal; Danijela Matic Vignjevic
Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Valerie N. Barton; Jessica L. Christenson; Michael A. Gordon; Lisa I. Greene; Thomas J. Rogers; Kiel Butterfield; Beatrice Babbs; Nicole S. Spoelstra; Nicholas C. D'Amato; Anthony Elias; Jennifer K. Richer
Therapeutics, Targets, and Chemical Biology
Targetable T-type Calcium Channels Drive Glioblastoma
Ying Zhang; Nichola Cruickshanks; Fang Yuan; Baomin Wang; Mary Pahuski; Julia Wulfkuhle; Isela Gallagher; Alexander F. Koeppel; Sarah Hatef; Christopher Papanicolas; Jeongwu Lee; Eli E. Bar; David Schiff; Stephen D. Turner; Emanuel F. Petricoin; Lloyd S. Gray; Roger Abounader
Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer
Hengyu Lu; Nicole Villafane; Turgut Dogruluk; Caitlin L. Grzeskowiak; Kathleen Kong; Yiu Huen Tsang; Oksana Zagorodna; Angeliki Pantazi; Lixing Yang; Nicholas J. Neill; Young Won Kim; Chad J. Creighton; Roel G. Verhaak; Gordon B. Mills; Peter J. Park; Raju Kucherlapati; Kenneth L. Scott
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses
Georg Karpel-Massler; Chiaki Tsuge Ishida; Elena Bianchetti; Chang Shu; Rolando Perez-Lorenzo; Basil Horst; Matei Banu; Kevin A. Roth; Jeffrey N. Bruce; Peter Canoll; Dario C. Altieri; Markus D. Siegelin
Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
Aleix Prat; Alejandro Navarro; Laia Paré; Noemí Reguart; Patricia Galván; Tomás Pascual; Alex Martínez; Paolo Nuciforo; Laura Comerma; Llucia Alos; Nuria Pardo; Susana Cedrés; Cheng Fan; Joel S. Parker; Lydia Gaba; Iván Victoria; Nuria Viñolas; Ana Vivancos; Ana Arance; Enriqueta Felip
EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases
Aria Vaishnavi; Laura Schubert; Uwe Rix; Lindsay A. Marek; Anh T. Le; Stephen B. Keysar; Magdalena J. Glogowska; Matthew A. Smith; Severine Kako; Natalia J. Sumi; Kurtis D. Davies; Kathryn E. Ware; Marileila Varella-Garcia; Eric B. Haura; Antonio Jimeno; Lynn E. Heasley; Dara L. Aisner; Robert C. Doebele
The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity
Susan L. Holbeck; Richard Camalier; James A. Crowell; Jeevan Prasaad Govindharajulu; Melinda Hollingshead; Lawrence W. Anderson; Eric Polley; Larry Rubinstein; Apurva Srivastava; Deborah Wilsker; Jerry M. Collins; James H. Doroshow
Microenvironment and Immunology
Author Choice
Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
Ramona Schlenker; Luis Felipe Olguín-Contreras; Matthias Leisegang; Julia Schnappinger; Anja Disovic; Svenja Rühland; Peter J. Nelson; Heinrich Leonhardt; Hartmann Harz; Susanne Wilde; Dolores J. Schendel; Wolfgang Uckert; Gerald Willimsky; Elfriede Noessner
STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy
Lekh N. Dahal; Lang Dou; Khiyam Hussain; Rena Liu; Alexander Earley; Kerry L. Cox; Salome Murinello; Ian Tracy; Francesco Forconi; Andrew J. Steele; Patrick J. Duriez; Diego Gomez-Nicola; Jessica L. Teeling; Martin J. Glennie; Mark S. Cragg; Stephen A. Beers
Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy
Sarita M. Fernandez-Poma; Diego Salas-Benito; Teresa Lozano; Noelia Casares; Jose-Ignacio Riezu-Boj; Uxua Mancheño; Edurne Elizalde; Diego Alignani; Natalia Zubeldia; Itziar Otano; Enrique Conde; Pablo Sarobe; Juan Jose Lasarte; Sandra Hervas-Stubbs
Author Choice
Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling
Claudio Tripodo; Alessia Burocchi; Pier Paolo Piccaluga; Claudia Chiodoni; Paola Portararo; Barbara Cappetti; Laura Botti; Alessandro Gulino; Alessandro Isidori; Arcangelo Liso; Giuseppe Visani; Maria Paola Martelli; Brunangelo Falini; Pier Paolo Pandolfi; Mario P. Colombo; Sabina Sangaletti
Prevention and Epidemiology
Retraction
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