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Infiltration of functionally competent cytotoxic (CD8+) T lymphocytes is necessary for effective immune surveillance in cancer. Kv1.3 potassium channels regulate the activation and function of T cells. This image depicts a section from a head and neck cancer stained for cytokeratin (tumor cell marker, yellow), CD8 (green), Ki-67 (cell proliferation marker, magenta), and Kv1.3 channels (red). The CD8+ lymphocytes that showed low Kv1.3 expression also showed decreased cell proliferation, indicating that Kv1.3 channels could be potential markers of the function of tumor-infiltrating T cells in head and neck cancer. For details, see article by Chimote and colleagues on page 53. - PDF Icon PDF LinkTable of Contents
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Cancer Research
Table of Contents
Breaking Advances
Integrated Systems and Technologies
Microenvironment and Immunology
Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer
Molecular and Cellular Pathobiology
HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone
Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
CRLX101, a Nanoparticle–Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α
Prevention and Epidemiology
Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort
Therapeutics, Targets, and Chemical Biology
Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors
PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis
Tumor and Stem Cell Biology
Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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