In commemoration of the 75th anniversary of Cancer Research, the Journal Editors have identified some of the most impactful articles published throughout the Journal's history. This year, Cancer Research has published and will continue to publish commentaries from authors, Editors, and other leaders in the field, reflecting on these important articles and how the field has continued to advance. This issue's cover offers a look back at some classic and distinctive covers from the Journal's rich history, featuring some key players, locations, and findings, and highlighting the impact the Journal has had in advancing cancer research and the mission of the AACR. For a more in-depth look at Cancer Research through the years, an interactive Anniversary timeline, and an archive of all Commentaries, please visit http://cancerres.aacrjournals.org/site/misc/75th_anniversary/CR75_timeline.html#timeline.