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15 April 2016
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In commemoration of the 75th anniversary of Cancer Research, the Journal Editors have identified some of the most impactful articles published throughout the Journal's history. This year, Cancer Research has published and will continue to publish commentaries from authors, Editors, and other leaders in the field, reflecting on these important articles and how the field has continued to advance. This issue's cover offers a look back at some classic and distinctive covers from the Journal's rich history, featuring some key players, locations, and findings, and highlighting the impact the Journal has had in advancing cancer research and the mission of the AACR. For a more in-depth look at Cancer Research through the years, an interactive Anniversary timeline, and an archive of all Commentaries, please visit http://cancerres.aacrjournals.org/site/misc/75th_anniversary/CR75_timeline.html#timeline. - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Cancer Research
Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentaries
Reviews
Priority Reports
Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients
Emmanuel Griessinger; Fernando Anjos-Afonso; Jacques Vargaftig; David C. Taussig; François Lassailly; Thomas Prebet; Véronique Imbert; Marielle Nebout; Norbert Vey; Christian Chabannon; Andrew Filby; Frederic Bollet-Quivogne; John G. Gribben; Jean-François Peyron; Dominique Bonnet
TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors
Laurie Menger; Anna Sledzinska; Katharina Bergerhoff; Frederick Arce Vargas; Julianne Smith; Laurent Poirot; Martin Pule; Javier Herrero; Karl S. Peggs; Sergio A. Quezada
Integrated Systems and Technologies
Microenvironment and Immunology
Author Choice
Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis
Franck Housseau; Shaoguang Wu; Elizabeth C. Wick; Hongni Fan; Xinqun Wu; Nicolas J. Llosa; Kellie N. Smith; Ada Tam; Sudipto Ganguly; Jane W. Wanyiri; Thevambiga Iyadorai; Ausama A. Malik; April C. Roslani; Jamunarani S. Vadivelu; Sara Van Meerbeke; David L. Huso; Drew M. Pardoll; Cynthia L. Sears
Author Choice
Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment
Andrew Stiff; Prashant Trikha; Robert Wesolowski; Kari Kendra; Vincent Hsu; Sarvani Uppati; Elizabeth McMichael; Megan Duggan; Amanda Campbell; Karen Keller; Ian Landi; Yiming Zhong; Jason Dubovsky; John Harrison Howard; Lianbo Yu; Bonnie Harrington; Matthew Old; Sean Reiff; Thomas Mace; Susheela Tridandapani; Natarajan Muthusamy; Michael A. Caligiuri; John C. Byrd; William E. Carson, III
Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity
Christine Pasero; Gwenaëlle Gravis; Mathilde Guerin; Samuel Granjeaud; Jeanne Thomassin-Piana; Palma Rocchi; Maria Paciencia-Gros; Flora Poizat; Mélanie Bentobji; Francine Azario-Cheillan; Jochen Walz; Naji Salem; Serge Brunelle; Alessandro Moretta; Daniel Olive
Author Choice
ILK Induction in Lymphoid Organs by a TNFα–NF-κB–Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia
Peter W. Krenn; Sebastian W. Hofbauer; Susanne Pucher; Evelyn Hutterer; Elisabeth Hinterseer; Ursula Denk; Daniela Asslaber; Sylvia Ganghammer; Christina Sternberg; Daniel Neureiter; Fritz Aberger; Sara A. Wickström; Alexander Egle; Richard Greil; Tanja N. Hartmann
Molecular and Cellular Pathobiology
Author Choice
Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse
Jason E. Farrar; Heather L. Schuback; Rhonda E. Ries; Daniel Wai; Oliver A. Hampton; Lisa R. Trevino; Todd A. Alonzo; Jaime M. Guidry Auvil; Tanja M. Davidsen; Patee Gesuwan; Leandro Hermida; Donna M. Muzny; Ninad Dewal; Navin Rustagi; Lora R. Lewis; Alan S. Gamis; David A. Wheeler; Malcolm A. Smith; Daniela S. Gerhard; Soheil Meshinchi
Prolyl Hydroxylase 3 Attenuates MCL-1–Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells
Praveenkumar Radhakrishnan; Nadine Ruh; Jonathan M. Harnoss; Judit Kiss; Martin Mollenhauer; Anna-Lena Scherr; Lisa K. Platzer; Thomas Schmidt; Klaus Podar; Joseph T. Opferman; Juergen Weitz; Henning Schulze-Bergkamen; Bruno C. Koehler; Alexis Ulrich; Martin Schneider
Author Choice
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Sangbin Lim; Hao Liu; Luciana Madeira da Silva; Ritu Arora; Zixing Liu; Joshua B. Phillips; David C. Schmitt; Tung Vu; Steven McClellan; Yifeng Lin; Wensheng Lin; Gary A. Piazza; Oystein Fodstad; Ming Tan
PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Ashley L. Hein; Parthasarathy Seshacharyulu; Satyanarayana Rachagani; Yuri M. Sheinin; Michel M. Ouellette; Moorthy P. Ponnusamy; Marc C. Mumby; Surinder K. Batra; Ying Yan
Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model
Stefan Thiem; Moritz F. Eissmann; Joachim Elzer; Anna Jonas; Tracy L. Putoczki; Ashleigh Poh; Paul Nguyen; Adele Preaudet; Dustin Flanagan; Elizabeth Vincan; Paul Waring; Michael Buchert; Andrew Jarnicki; Matthias Ernst
Prevention and Epidemiology
Author Choice
A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Ruth C. Travis; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Paul N. Appleby; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Richard M. Martin; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Jeff M.P. Holly; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Demetrius Albanes; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Amanda Black; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; H. Bas Bueno-de-Mesquita; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; June M. Chan; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Chu Chen; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Maria-Dolores Chirlaque; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Michael B. Cook; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Mélanie Deschasaux; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Jenny L. Donovan; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Luigi Ferrucci; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Pilar Galan; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Graham G. Giles; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Edward L. Giovannucci; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Marc J. Gunter; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Laurel A. Habel; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Freddie C. Hamdy; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Kathy J. Helzlsouer; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Serge Hercberg; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Robert N. Hoover; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Joseph A.M.J.L. Janssen; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Rudolf Kaaks; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Tatsuhiko Kubo; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Loic Le Marchand; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; E. Jeffrey Metter; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Kazuya Mikami; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Joan K. Morris; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; David E. Neal; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Marian L. Neuhouser; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Kotaro Ozasa; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Domenico Palli; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Elizabeth A. Platz; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Michael N. Pollak; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Alison J. Price; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Monique J. Roobol; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Catherine Schaefer; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Jeannette M. Schenk; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Gianluca Severi; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Meir J. Stampfer; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Pär Stattin; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Akiko Tamakoshi; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Catherine M. Tangen; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Mathilde Touvier; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Nicholas J. Wald; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Noel S. Weiss; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Regina G. Ziegler; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Timothy J. Key; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group; Naomi E. Allen; on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group
Therapeutics, Targets, and Chemical Biology
Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer
Maria Teresa Herrera-Abreu; Marta Palafox; Uzma Asghar; Martín A. Rivas; Rosalind J. Cutts; Isaac Garcia-Murillas; Alex Pearson; Marta Guzman; Olga Rodriguez; Judit Grueso; Meritxell Bellet; Javier Cortés; Richard Elliott; Sunil Pancholi; Christopher J. Lord; José Baselga; Mitch Dowsett; Lesley-Ann Martin; Nicholas C. Turner; Violeta Serra
Author Choice
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade
Alexandra Eichten; Jia Su; Alexander P. Adler; Li Zhang; Ella Ioffe; Asma A. Parveen; George D. Yancopoulos; John Rudge; Israel Lowy; Hsin Chieh Lin; Douglas MacDonald; Christopher Daly; Xunbao Duan; Gavin Thurston
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Lars Bräutigam; Linda Pudelko; Ann-Sofie Jemth; Helge Gad; Mohit Narwal; Robert Gustafsson; Stella Karsten; Jordi Carreras Puigvert; Evert Homan; Carsten Berndt; Ulrika Warpman Berglund; Pål Stenmark; Thomas Helleday
Tumor and Stem Cell Biology
Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes
Geoffrey J. Markowitz; Pengyuan Yang; Jing Fu; Gregory A. Michelotti; Rui Chen; Jianhua Sui; Bin Yang; Wen-Hao Qin; Zheng Zhang; Fu-Sheng Wang; Anna Mae Diehl; Qi-Jing Li; Hongyang Wang; Xiao-Fan Wang
Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models
Josephine Kam Tai Dermawan; Masahiro Hitomi; Daniel J. Silver; Qiulian Wu; Poorva Sandlesh; Andrew E. Sloan; Andrei A. Purmal; Katerina V. Gurova; Jeremy N. Rich; Justin D. Lathia; George R. Stark; Monica Venere
Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow
Regina Miftakhova; Andreas Hedblom; Julius Semenas; Brian Robinson; Athanasios Simoulis; Johan Malm; Albert Rizvanov; David M. Heery; Nigel P. Mongan; Norman J. Maitland; Cinzia Allegrucci; Jenny L. Persson
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo
Christopher G. Hubert; Maricruz Rivera; Lisa C. Spangler; Qiulian Wu; Stephen C. Mack; Briana C. Prager; Marta Couce; Roger E. McLendon; Andrew E. Sloan; Jeremy N. Rich
Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia
Cristina Prieto; Ronald W. Stam; Antonio Agraz-Doblas; Paola Ballerini; Mireia Camos; Julio Castaño; Rolf Marschalek; Aldeheid Bursen; Ignacio Varela; Clara Bueno; Pablo Menendez
Retractions
Correction
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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