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1 April 2016
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Cover Image
Accumulating evidence suggests a major role for cancer stem cells (CSC) in chemoresistance. An interplay between breast CSCs and non-CSCs involving NFκB/IL6 paracrine loop was decoded as the mechanism responsible for expansion of invasive, chemoresistant CSC population in patients suffering from disease relapse after chemotherapy. The image shows immunostaining for NFκB (brown), a pivotal inflammatory regulator, in primary tumors of patients with breast cancer that acquired aggressive phenotype following chemotherapy. Prior treatment with aspirin suppressed acquisition of chemoresistance by perturbing NFκB nuclear translocation in pre-existing CSCs. Thus, combining aspirin and chemotherapy may offer a new treatment strategy to improve recurrence-free survival of breast cancer patients. For details, see article by Saha and colleagues on page 2000.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentaries
Reviews
Priority Reports
Author Choice
Notch4 Signaling Induces a Mesenchymal–Epithelial–like Transition in Melanoma Cells to Suppress Malignant Behaviors
Ehsan Bonyadi Rad; Heinz Hammerlindl; Christian Wels; Ulrich Popper; Dinoop Ravindran Menon; Heimo Breiteneder; Melitta Kitzwoegerer; Christine Hafner; Meenhard Herlyn; Helmut Bergler; Helmut Schaider
Integrated Systems and Technologies
Author Choice
Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer
Nan Hu; Mitsutaka Kadota; Huaitian Liu; Christian C. Abnet; Hua Su; Hailong Wu; Neal D. Freedman; Howard H. Yang; Chaoyu Wang; Chunhua Yan; Lemin Wang; Sheryl Gere; Amy Hutchinson; Guohong Song; Yuan Wang; Ti Ding; You-Lin Qiao; Jill Koshiol; Sanford M. Dawsey; Carol Giffen; Alisa M. Goldstein; Philip R. Taylor; Maxwell P. Lee
Author Choice
Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability
Xiangchun Li; William K.K. Wu; Rui Xing; Sunny H. Wong; Yuexin Liu; Xiaodong Fang; Yanlin Zhang; Mengyao Wang; Jiaqian Wang; Lin Li; Yong Zhou; Senwei Tang; Shaoliang Peng; Kunlong Qiu; Longyun Chen; Kexin Chen; Huanming Yang; Wei Zhang; Matthew T.V. Chan; Youyong Lu; Joseph J.Y. Sung; Jun Yu
An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer
Aleksandra Olow; Zhongzhong Chen; R. Hannes Niedner; Denise M. Wolf; Christina Yau; Aleksandr Pankov; Evelyn Pei Rong Lee; Lamorna Brown-Swigart; Laura J. van ‘t Veer; Jean-Philippe Coppé
Microenvironment and Immunology
Author Choice
Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis
Jitka Fucikova; Etienne Becht; Kristina Iribarren; Jeremy Goc; Romain Remark; Diane Damotte; Marco Alifano; Priyanka Devi; Jerome Biton; Claire Germain; Audrey Lupo; Wolf Herve Fridman; Marie-Caroline Dieu-Nosjean; Guido Kroemer; Catherine Sautès-Fridman; Isabelle Cremer
Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients
Mimma Bianco; Anna Maria Gasparri; Barbara Colombo; Flavio Curnis; Stefania Girlanda; Maurilio Ponzoni; Maria Teresa Sabrina Bertilaccio; Arianna Calcinotto; Angelina Sacchi; Elisabetta Ferrero; Marina Ferrarini; Marta Chesi; P. Leif Bergsagel; Matteo Bellone; Giovanni Tonon; Fabio Ciceri; Magda Marcatti; Federico Caligaris-Cappio; Angelo Corti
Author Choice
Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Lucia De Monte; Sonja Wörmann; Emanuela Brunetto; Silvia Heltai; Gilda Magliacane; Michele Reni; Anna Maria Paganoni; Helios Recalde; Anna Mondino; Massimo Falconi; Francesca Aleotti; Gianpaolo Balzano; Hana Algül; Claudio Doglioni; Maria Pia Protti
Molecular and Cellular Pathobiology
Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Mizuo Ando; Masahito Kawazu; Toshihide Ueno; Daizo Koinuma; Koji Ando; Junji Koya; Keisuke Kataoka; Takahiko Yasuda; Hiroyuki Yamaguchi; Kazutaka Fukumura; Azusa Yamato; Manabu Soda; Eirin Sai; Yoshihiro Yamashita; Takahiro Asakage; Yasushi Miyazaki; Mineo Kurokawa; Kohei Miyazono; Stephen D. Nimer; Tatsuya Yamasoba; Hiroyuki Mano
Mutational Landscape of Aggressive Prostate Tumors in African American Men
Karla J. Lindquist; Pamela L. Paris; Thomas J. Hoffmann; Niall J. Cardin; Rémi Kazma; Joel A. Mefford; Jeffrey P. Simko; Vy Ngo; Yalei Chen; Albert M. Levin; Dhananjay Chitale; Brian T. Helfand; William J. Catalona; Benjamin A. Rybicki; John S. Witte
Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
Tatiana Popova; Elodie Manié; Valentina Boeva; Aude Battistella; Oumou Goundiam; Nicholas K. Smith; Christopher R. Mueller; Virginie Raynal; Odette Mariani; Xavier Sastre-Garau; Marc-Henri Stern
Prevention and Epidemiology
Author Choice
Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus
Nicola J. Camp; Wei-Yu Lin; Alex Bigelow; George J. Burghel; Timothy L. Mosbruger; Marina A. Parry; Rosalie G. Waller; Sushilaben H. Rigas; Pei-Yi Tai; Kristofer Berrett; Venkatesh Rajamanickam; Rachel Cosby; Ian W. Brock; Brandt Jones; Dan Connley; Robert Sargent; Guoying Wang; Rachel E. Factor; Philip S. Bernard; Lisa Cannon-Albright; Stacey Knight; Ryan Abo; Theresa L. Werner; Malcolm W.R. Reed; Jason Gertz; Angela Cox
The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women
Sung Jin Huh; Hannah Oh; Michael A. Peterson; Vanessa Almendro; Rong Hu; Michaela Bowden; Rosina L. Lis; Maura B. Cotter; Massimo Loda; William T. Barry; Kornelia Polyak; Rulla M. Tamimi
Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals
Jonathan N. Hofmann; Brenda M. Birmann; Lauren R. Teras; Ruth M. Pfeiffer; Ye Wang; Demetrius Albanes; Dalsu Baris; Graham A. Colditz; Anneclaire J. De Roos; Graham G. Giles; H. Dean Hosgood; Qing Lan; Ola Landgren; Linda M. Liao; Nathaniel Rothman; Stephanie J. Weinstein; Michael N. Pollak; Marian L. Neuhouser; Mark P. Purdue
Therapeutics, Targets, and Chemical Biology
Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
Petra den Hollander; Kathryn Rawls; Anna Tsimelzon; Jonathan Shepherd; Abhijit Mazumdar; Jamal Hill; Suzanne A.W. Fuqua; Jenny C. Chang; C. Kent Osborne; Susan G. Hilsenbeck; Gordon B. Mills; Powel H. Brown
Identification of DNA Methylation–Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma
Elinne Becket; Sameer Chopra; Christopher E. Duymich; Justin J. Lin; Jueng Soo You; Kurinji Pandiyan; Peter W. Nichols; Kimberly D. Siegmund; Jessica Charlet; Daniel J. Weisenberger; Peter A. Jones; Gangning Liang
Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer
Chinthalapally V. Rao; Naveena B. Janakiram; Venkateshwar Madka; Gaurav Kumar; Edgar J. Scott; Gopal Pathuri; Taylor Bryant; Hannah Kutche; Yuting Zhang; Laura Biddick; Hariprasad Gali; Yan D. Zhao; Stan Lightfoot; Altaf Mohammed
Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes
John P. McGrath; Kaylyn E. Williamson; Srividya Balasubramanian; Shobu Odate; Shilpi Arora; Charlie Hatton; Thomas M. Edwards; Thomas O'Brien; Steven Magnuson; David Stokoe; Danette L. Daniels; Barbara M. Bryant; Patrick Trojer
Tumor and Stem Cell Biology
Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells
Shilpi Saha; Shravanti Mukherjee; Poulami Khan; Kirti Kajal; Minakshi Mazumdar; Argha Manna; Sanhita Mukherjee; Sunanda De; Debarshi Jana; Diptendra K. Sarkar; Tanya Das
Combined Treatment with Epigenetic, Differentiating, and Chemotherapeutic Agents Cooperatively Targets Tumor-Initiating Cells in Triple-Negative Breast Cancer
Vanessa F. Merino; Nguyen Nguyen; Kideok Jin; Helen Sadik; Soonweng Cho; Preethi Korangath; Liangfeng Han; Yolanda M.N. Foster; Xian C. Zhou; Zhe Zhang; Roisin M. Connolly; Vered Stearns; Syed Z. Ali; Christina Adams; Qian Chen; Duojia Pan; David L. Huso; Peter Ordentlich; Angela Brodie; Saraswati Sukumar
Letters to the Editor
Correction
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