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1 February 2016
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Cover Image
The monomeric Casitas B-lineage lymphoma (c-Cbl, CBL) RING finger ubiquitin ligase (blue) can bind to phosphorylated RTK (orange peptide) via the TKBD domain. Upon phosphorylation, CBL undergoes a large conformational change that positions the ubiquitin-conjugating enzyme E2 (green) active site close to RTK. Cancer mutation sites are mapped on the structure of the complex and are shown in yellow; Zn ions are shown as blue balls. Other stages of the CBL activation cycle are depicted in Figure 1 of the article. For details, see article by Li and colleagues on page 561.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentaries
Review
Priority Report
Clinical Studies
Author Choice
Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
Lale Erdem-Eraslan; Martin J. van den Bent; Youri Hoogstrate; Hina Naz-Khan; Andrew Stubbs; Peter van der Spek; René Böttcher; Ya Gao; Maurice de Wit; Walter Taal; Hendrika M. Oosterkamp; Annemiek Walenkamp; Laurens V. Beerepoot; Monique C.J. Hanse; Jan Buter; Aafke H. Honkoop; Bronno van der Holt; René M. Vernhout; Peter A.E. Sillevis Smitt; Johan M. Kros; Pim J. French
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Dongwon Choi; Swapnika Ramu; Eunkyung Park; Eunson Jung; Sara Yang; Wonhyeuk Jung; Inho Choi; Sunju Lee; Kyu Eui Kim; Young Jin Seong; Mingu Hong; George Daghlian; Daniel Kim; Eugene Shin; Jung In Seo; Vicken Khatchadourian; Mengchen Zou; Wei Li; Roger De Filippo; Paul Kokorowski; Andy Chang; Steve Kim; Ana Bertoni; Tania Weber Furlanetto; Sung Shin; Meng Li; Yibu Chen; Alex Wong; Chester Koh; Jan Geliebter; Young-Kwon Hong
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression
Michela Borghesan; Caterina Fusilli; Francesca Rappa; Concetta Panebianco; Giovanni Rizzo; Jude A. Oben; Gianluigi Mazzoccoli; Chris Faulkes; Illar Pata; Antonella Agodi; Farhad Rezaee; Shane Minogue; Alessandra Warren; Abigail Peterson; John M. Sedivy; Julien Douet; Marcus Buschbeck; Francesco Cappello; Tommaso Mazza; Valerio Pazienza; Manlio Vinciguerra
SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
David Crottès; Raphael Rapetti-Mauss; Francisca Alcaraz-Perez; Mélanie Tichet; Giuseppina Gariano; Sonia Martial; Hélène Guizouarn; Bernard Pellissier; Agnès Loubat; Alexandra Popa; Agnès Paquet; Marco Presta; Sophie Tartare-Deckert; Maria Luisa Cayuela; Patrick Martin; Franck Borgese; Olivier Soriani
PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease
Zejuan Li; Ping Chen; Rui Su; Chao Hu; Yuanyuan Li; Abdel G. Elkahloun; Zhixiang Zuo; Sandeep Gurbuxani; Stephen Arnovitz; Hengyou Weng; Yungui Wang; Shenglai Li; Hao Huang; Mary Beth Neilly; Gang Greg Wang; Xi Jiang; Paul P. Liu; Jie Jin; Jianjun Chen
Prevention and Epidemiology
Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1−/+ Mice
Chinthalapally V. Rao; Saira Sanghera; Yuting Zhang; Laura Biddick; Arun Reddy; Stan Lightfoot; Naveena B. Janakiram; Altaf Mohammed; Wei Dai; Hiroshi Y. Yamada
Therapeutics, Targets, and Chemical Biology
Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations
Erick Riquelme; Carmen Behrens; Heather Y. Lin; George Simon; Vassiliki Papadimitrakopoulou; Julie Izzo; Cesar Moran; Neda Kalhor; J. Jack Lee; John D. Minna; Ignacio I. Wistuba
Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity
Su-Chan Lee; Hye-Young Min; Hoon Choi; Song Yi Bae; Kwan Hee Park; Seung Yeob Hyun; Ho Jin Lee; Jayoung Moon; Shin-Hyung Park; Jun Yong Kim; Hongchan An; So-Jung Park; Ji Hae Seo; Seungbeom Lee; Young-Myeong Kim; Hyun-Ju Park; Sang Kook Lee; Jeewoo Lee; Jeeyeon Lee; Kyu-Won Kim; Young-Ger Suh; Ho-Young Lee
Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity
Niklas K. Finnberg; Prashanth Gokare; Arunasalam Navaraj; Krystle A. Lang Kuhs; George Cerniglia; Hideo Yagita; Kazuyoshi Takeda; Noboru Motoyama; Wafik S. El-Deiry
Tumor and Stem Cell Biology
Author Choice
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
Cecile Chartier; Janak Raval; Fumiko Axelrod; Chris Bond; Jennifer Cain; Cristina Dee-Hoskins; Shirley Ma; Marcus M. Fischer; Jalpa Shah; Jie Wei; May Ji; Andrew Lam; Michelle Stroud; Wan-Ching Yen; Pete Yeung; Belinda Cancilla; Gilbert O'Young; Min Wang; Ann M. Kapoun; John Lewicki; Timothy Hoey; Austin Gurney
Author Choice
Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
Anna A. Marusiak; Natalie L. Stephenson; Hayeon Baik; Eleanor W. Trotter; Yaoyong Li; Karen Blyth; Susan Mason; Phil Chapman; Lorena A. Puto; Jon A. Read; Claire Brassington; Hannah K. Pollard; Chris Phillips; Isabelle Green; Ross Overman; Matthew Collier; Ewelina Testoni; Crispin J. Miller; Tony Hunter; Owen J. Sansom; John Brognard
Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Stephen J. Murphy; Steven N. Hart; Geoffrey C. Halling; Sarah H. Johnson; James B. Smadbeck; Travis Drucker; Joema Felipe Lima; Fariborz Rakhshan Rohakhtar; Faye R. Harris; Farhad Kosari; Subbaya Subramanian; Gloria M. Petersen; Timothy D. Wiltshire; Benjamin R. Kipp; Mark J. Truty; Robert R. McWilliams; Fergus J. Couch; George Vasmatzis
Correction
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