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15 October 2016
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IL34 is expressed in primary lung adenocarcinoma tissues and correlates with poor prognosis in cancer patients. IL34, a cytokine that acts as a second ligand for CSF1R, was found to be induced and controlled by chronic activation of NF-κB in chemoresistant lung cancer cells. In vitro and in vivo experiments unveiled a dual role for IL34 in cancer chemoresistance. IL34 was found to enhance local immunosuppression by tumor-associated macrophages and also provides cancer cells with a critical survival signal to overcome chemotherapeutic conditions. For details, see article by Baghdadi and colleagues on page 6030.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentary
Reviews
Priority Report
Clinical Studies
Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging
Bruce J. Tromberg; Zheng Zhang; Anaïs Leproux; Thomas D. O'Sullivan; Albert E. Cerussi; Philip M. Carpenter; Rita S. Mehta; Darren Roblyer; Wei Yang; Keith D. Paulsen; Brian W. Pogue; Shudong Jiang; Peter A. Kaufman; Arjun G. Yodh; So Hyun Chung; Mitchell Schnall; Bradley S. Snyder; Nola Hylton; David A. Boas; Stefan A. Carp; Steven J. Isakoff; David Mankoff; on behalf of the ACRIN 6691 investigators
Water Concentration Analysis by Raman Spectroscopy to Determine the Location of the Tumor Border in Oral Cancer Surgery
Elisa M. Barroso; Roeland W.H. Smits; Cornelia G.F. van Lanschot; Peter J. Caspers; Ivo ten Hove; Hetty Mast; Aniel Sewnaik; José A. Hardillo; Cees A. Meeuwis; Rob Verdijk; Vincent Noordhoek Hegt; Robert J. Baatenburg de Jong; Eppo B. Wolvius; Tom C. Bakker Schut; Senada Koljenović; Gerwin J. Puppels
Integrated Systems and Technologies
Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Yu Fu; Cécile Jovelet; Thomas Filleron; Marion Pedrero; Nelly Motté; Yannick Boursin; Yufei Luo; Christophe Massard; Mario Campone; Christelle Levy; Véronique Diéras; Thomas Bachelot; Julie Garrabey; Jean-Charles Soria; Ludovic Lacroix; Fabrice André; Celine Lefebvre
Microenvironment and Immunology
Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
María E. Rodriguez-Ruiz; Inmaculada Rodriguez; Saray Garasa; Benigno Barbes; Jose Luis Solorzano; Jose Luis Perez-Gracia; Sara Labiano; Miguel F. Sanmamed; Arantza Azpilikueta; Elixabet Bolaños; Alfonso R. Sanchez-Paulete; M. Angela Aznar; Ana Rouzaut; Kurt A. Schalper; Maria Jure-Kunkel; Ignacio Melero
Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Muhammad Baghdadi; Haruka Wada; Sayaka Nakanishi; Hirotake Abe; Nanumi Han; Wira Eka Putra; Daisuke Endo; Hidemichi Watari; Noriaki Sakuragi; Yasuhiro Hida; Kichizo Kaga; Yohei Miyagi; Tomoyuki Yokose; Atsushi Takano; Yataro Daigo; Ken-ichiro Seino
Molecular and Cellular Pathobiology
Prevention and Epidemiology
Impact of Serum Antibodies to HPV Serotypes 6, 11, 16, and 18 to Risks of Subsequent Genital HPV Infections in Men: The HIM Study
Shitaldas J. Pamnani; Staci L. Sudenga; Raphael Viscidi; Dana E. Rollison; B. Nelson Torres; Donna J. Ingles; Martha Abrahamsen; Luisa L. Villa; Eduardo Lazcano-Ponce; Jorge Salmeron; Manuel Quiterio; Yangxin Huang; Amy Borenstein; Anna R. Giuliano
Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults
Peter T. Campbell; Christina C. Newton; Neal D. Freedman; Jill Koshiol; Michael C. Alavanja; Laura E. Beane Freeman; Julie E. Buring; Andrew T. Chan; Dawn Q. Chong; Mridul Datta; Mia M. Gaudet; J. Michael Gaziano; Edward L. Giovannucci; Barry I. Graubard; Albert R. Hollenbeck; Lindsey King; I.-Min Lee; Martha S. Linet; Julie R. Palmer; Jessica L. Petrick; Jenny N. Poynter; Mark P. Purdue; Kim Robien; Lynn Rosenberg; Vikrant V. Sahasrabuddhe; Catherine Schairer; Howard D. Sesso; Alice J. Sigurdson; Victoria L. Stevens; Jean Wactawski-Wende; Anne Zeleniuch-Jacquotte; Andrew G. Renehan; Katherine A. McGlynn
Therapeutics, Targets, and Chemical Biology
Author Choice
The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models
Lenka Oplustil O'Connor; Stuart L. Rulten; Aaron N. Cranston; Rajesh Odedra; Henry Brown; Janneke E. Jaspers; Louise Jones; Charlotte Knights; Bastiaan Evers; Attilla Ting; Robert H. Bradbury; Marina Pajic; Sven Rottenberg; Jos Jonkers; David Rudge; Niall M.B. Martin; Keith W. Caldecott; Alan Lau; Mark J. O'Connor
Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma
Francesca Bersani; Marcello Francesco Lingua; Deborah Morena; Valentina Foglizzo; Silvia Miretti; Letizia Lanzetti; Giovanna Carrà; Alessandro Morotti; Ugo Ala; Paolo Provero; Roberto Chiarle; Samuel Singer; Marc Ladanyi; Thomas Tuschl; Carola Ponzetto; Riccardo Taulli
Tumor and Stem Cell Biology
WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma
Sara Del Mare; Hussam Husanie; Ortal Iancu; Mohammad Abu-Odeh; Konstantinos Evangelou; Francesca Lovat; Stefano Volinia; Jonathan Gordon; Gail Amir; Janet Stein; Gary S. Stein; Carlo M. Croce; Vassilis Gorgoulis; Jane B. Lian; Rami I. Aqeilan
Author Choice
CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma
Josephine Walton; Julianna Blagih; Darren Ennis; Elaine Leung; Suzanne Dowson; Malcolm Farquharson; Laura A. Tookman; Clare Orange; Dimitris Athineos; Susan Mason; David Stevenson; Karen Blyth; Douglas Strathdee; Frances R. Balkwill; Karen Vousden; Michelle Lockley; Iain A. McNeish
Corrections
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