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15 January 2016
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Cover Image
Cover Image
Overall structure of a survivin dimer with deeply buried dimerization core residues shown by their molecular surface in gray and noncore residues shown by sticks in green. Qi and colleagues show that the deeply buried dimerization core residues in undruggable oncogenic dimeric proteins can be targeted using computational approaches for drug discovery to destroy these proteins. Specifically, a lead small-molecule inhibitor LQZ-7F targeting the dimerization core residues of survivin was discovered that induced proteasome-dependent survivin degradation, mitotic arrest, apoptosis, and blocked the growth of human xenograft tumors. For details, see article by Qi and colleagues on page 453.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentaries
Review
Meeting Report
Priority Report
Clinical Studies
Integrated Systems and Technologies
Author Choice
Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Bogumil Kaczkowski; Yuji Tanaka; Hideya Kawaji; Albin Sandelin; Robin Andersson; Masayoshi Itoh; Timo Lassmann; Yoshihide Hayashizaki; Piero Carninci; Alistair R.R. Forrest; the FANTOM5 consortium
Microenvironment and Immunology
Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer
Kristin J. Lastwika; Willie Wilson, III; Qing Kay Li; Jeffrey Norris; Haiying Xu; Sharon R. Ghazarian; Hiroshi Kitagawa; Shigeru Kawabata; Janis M. Taube; Sheng Yao; Linda N. Liu; Joell J. Gills; Phillip A. Dennis
PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB
Lavakumar Karyampudi; Purushottam Lamichhane; James Krempski; Kimberly R. Kalli; Marshall D. Behrens; Doris M. Vargas; Lynn C. Hartmann; Jo Marie T. Janco; Haidong Dong; Karen E. Hedin; Allan B. Dietz; Ellen L. Goode; Keith L. Knutson
PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
Nisha Nagarsheth; Dongjun Peng; Ilona Kryczek; Ke Wu; Wei Li; Ende Zhao; Lili Zhao; Shuang Wei; Timothy Frankel; Linda Vatan; Wojciech Szeliga; Yali Dou; Scott Owens; Victor Marquez; Kaixiong Tao; Emina Huang; Guobin Wang; Weiping Zou
Molecular and Cellular Pathobiology
Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer
Gretchen K. Hubbard; Laura N. Mutton; May Khalili; Ryan P. McMullin; Jessica L. Hicks; Daniella Bianchi-Frias; Lucas A. Horn; Ibrahim Kulac; Michael S. Moubarek; Peter S. Nelson; Srinivasan Yegnasubramanian; Angelo M. De Marzo; Charles J. Bieberich
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer
Katherine R. Amato; Shan Wang; Li Tan; Andrew K. Hastings; Wenqiang Song; Christine M. Lovly; Catherine B. Meador; Fei Ye; Pengcheng Lu; Justin M. Balko; Daniel C. Colvin; Justin M. Cates; William Pao; Nathanael S. Gray; Jin Chen
Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Assunta De Rienzo; Michael A. Archer; Beow Y. Yeap; Nhien Dao; Daniele Sciaranghella; Antonios C. Sideris; Yifan Zheng; Alexander G. Holman; Yaoyu E. Wang; Paola S. Dal Cin; Jonathan A. Fletcher; Renee Rubio; Larry Croft; John Quackenbush; Peter E. Sugarbaker; Kiara J. Munir; Jesse R. Battilana; Corinne E. Gustafson; Lucian R. Chirieac; Soo Meng Ching; James Wong; Liang Chung Tay; Stephen Rudd; Robert Hercus; David J. Sugarbaker; William G. Richards; Raphael Bueno
Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin–GUCY2C Paracrine Signaling Axis
Jieru E. Lin; Francheska Colon-Gonzalez; Erik Blomain; Gilbert W. Kim; Amanda Aing; Brian Stoecker; Justin Rock; Adam E. Snook; Tingting Zhan; Terry M. Hyslop; Michal Tomczak; Richard S. Blumberg; Scott A. Waldman
Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix–Directed Spheroid Formation
Yuta Kasagi; Yui Harada; Yosuke Morodomi; Toshiki Iwai; Satoru Saito; Kumi Yoshida; Eiji Oki; Hiroshi Saeki; Kippei Ohgaki; Masahiko Sugiyama; Mitsuho Onimaru; Yoshihiko Maehara; Yoshikazu Yonemitsu
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Yusuke Shono; Andrea Z. Tuckett; Hsiou-Chi Liou; Ekaterina Doubrovina; Enrico Derenzini; Samedy Ouk; Jennifer J. Tsai; Odette M. Smith; Emily R. Levy; Fabiana M. Kreines; Carly G.K. Ziegler; Mary I. Scallion; Mikhail Doubrovin; Glenn Heller; Anas Younes; Richard J. O'Reilly; Marcel R.M. van den Brink; Johannes L. Zakrzewski
Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Barbara Herkert; Audrey Kauffmann; Sandra Mollé; Christian Schnell; Thomas Ferrat; Hans Voshol; Janina Juengert; Hélène Erasimus; Grégory Marszalek; Malika Kazic-Legueux; Eric Billy; David Ruddy; Mark Stump; Daniel Guthy; Mitko Ristov; Keith Calkins; Sauveur-Michel Maira; William R. Sellers; Francesco Hofmann; Michael N. Hall; Saskia M. Brachmann
An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo
Stefan Lohse; Saskia Meyer; Laura A.P.M. Meulenbroek; J.H. Marco Jansen; Maaike Nederend; Anna Kretschmer; Katja Klausz; Uwe Möginger; Stefanie Derer; Thies Rösner; Christian Kellner; Denis Schewe; Peter Sondermann; Sanjay Tiwari; Daniel Kolarich; Matthias Peipp; Jeanette H.W. Leusen; Thomas Valerius
Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology
Samikshan Dutta; Sohini Roy; Navatha S. Polavaram; Marissa J. Stanton; Heyu Zhang; Tanvi Bhola; Pia Hönscheid; Terrence M. Donohue, Jr.; Hamid Band; Surinder K. Batra; Michael H. Muders; Kaustubh Datta
Tumor and Stem Cell Biology
A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors
Haihong Zhong; April Davis; Maria Ouzounova; Rosa A. Carrasco; Cui Chen; Shannon Breen; Yong S. Chang; Jiaqi Huang; Zheng Liu; Yihong Yao; Elaine Hurt; Jacques Moisan; Michael Fung; David A. Tice; Shawn G. Clouthier; Zhan Xiao; Max S. Wicha; Hasan Korkaya; Robert E. Hollingsworth
Author Choice
Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b–Mediated Malignant Progression
Manuel Picon-Ruiz; Chendong Pan; Katherine Drews-Elger; Kibeom Jang; Alexandra H. Besser; Dekuang Zhao; Cynthia Morata-Tarifa; Minsoon Kim; Tan A. Ince; Diana J. Azzam; Seth A. Wander; Bin Wang; Burcu Ergonul; Ram H. Datar; Richard J. Cote; Guy A. Howard; Dorraya El-Ashry; Pablo Torné-Poyatos; Juan A. Marchal; Joyce M. Slingerland
Correction
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