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Volume 76, Issue 14
15 July 2016
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    Epithelial–mesenchymal transition induces tissue factor expression and coagulant properties that drive early metastasis of circulating tumor cells. Using immunofluorescence, vimentin-expressing tumor cells (red) surrounded by platelet-rich microthrombi (blue) were observed colonizing lungs in experimental models of metastasis (nuclei, white). For details, see article by Bourcy and colleagues on page 4270.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Cancer Research 75th Anniversary Commentaries

Colon Cancer Germline Genetics: The Unbelievable Year 1993 and Thereafter
Albert de la Chapelle
View articletitled, Colon Cancer Germline Genetics: The Unbelievable Year 1993 and Thereafter
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The Role of CagA in the Gastric Biology of Helicobacter pylori
Steffen Backert; Martin J. Blaser
View articletitled, The Role of CagA in the Gastric Biology of <em>Helicobacter pylori</em>
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Review

Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data
Kathleen A. Ashcraft; Ralph M. Peace; Allison S. Betof; Mark W. Dewhirst; Lee W. Jones
View articletitled, Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of <em>In Vivo</em> Preclinical Data
Supplementary data
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Priority Report

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
Ikrame Lazar; Emily Clement; Stéphanie Dauvillier; Delphine Milhas; Manuelle Ducoux-Petit; Sophie LeGonidec; Cédric Moro; Vanessa Soldan; Stéphane Dalle; Stéphanie Balor; Muriel Golzio; Odile Burlet-Schiltz; Philippe Valet; Catherine Muller; Laurence Nieto
View articletitled, Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
Supplementary data
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Integrated Systems and Technologies

Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Ashwini Kumar Sharma; Roland Eils; Rainer König
View articletitled, Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Supplementary data
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Author Choice
Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins
Edward Hitti; Tala Bakheet; Norah Al-Souhibani; Walid Moghrabi; Suhad Al-Yahya; Maha Al-Ghamdi; Maher Al-Saif; Mohamed M. Shoukri; András Lánczky; Renaud Grépin; Balázs Győrffy; Gilles Pagès; Khalid S.A. Khabar
View articletitled, Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins
Supplementary data
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VEGFR2-Targeted Three-Dimensional Ultrasound Imaging Can Predict Responses to Antiangiogenic Therapy in Preclinical Models of Colon Cancer
Jianhua Zhou; Huaijun Wang; Huiping Zhang; Amelie M. Lutz; Lu Tian; Dimitre Hristov; Jürgen K. Willmann
View articletitled, VEGFR2-Targeted Three-Dimensional Ultrasound Imaging Can Predict Responses to Antiangiogenic Therapy in Preclinical Models of Colon Cancer
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Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Nathaniel Weygant; Yang Ge; Dongfeng Qu; John S. Kaddis; William L. Berry; Randal May; Parthasarathy Chandrakesan; Edwin Bannerman-Menson; Kenneth J. Vega; James J. Tomasek; Michael S. Bronze; Guangyu An; Courtney W. Houchen
View articletitled, Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase
Supplementary data
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Microenvironment and Immunology

Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Laurent Beziaud; Laura Mansi; Patrice Ravel; Elodie Lauret Marie-Joseph; Caroline Laheurte; Laurie Rangan; Francis Bonnefoy; Jean-René Pallandre; Laura Boullerot; Clémentine Gamonet; Sindy Vrecko; Lise Queiroz; Tristan Maurina; Guillaume Mouillet; Thierry Nguyen Tan Hon; Elsa Curtit; Bernard Royer; Béatrice Gaugler; Jagadeesh Bayry; Eric Tartour; Antoine Thiery-Vuillemin; Xavier Pivot; Christophe Borg; Yann Godet; Olivier Adotévi
View articletitled, Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity
Supplementary data
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Immuno-PET Imaging of Engineered Human T Cells in Tumors
Sabine Mall; Nahid Yusufi; Ricarda Wagner; Richard Klar; Henrique Bianchi; Katja Steiger; Melanie Straub; Stefan Audehm; Iina Laitinen; Michaela Aichler; Christian Peschel; Sibylle Ziegler; Mona Mustafa; Markus Schwaiger; Calogero D'Alessandria; Angela M. Krackhardt
View articletitled, Immuno-PET Imaging of Engineered Human T Cells in Tumors
Supplementary data
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FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
Xuguang Yang; Yuli Lin; Yinghong Shi; Bingji Li; Weiren Liu; Wei Yin; Yongjun Dang; Yiwei Chu; Jia Fan; Rui He
View articletitled, FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
Supplementary data
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Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma
Christian H. Ottensmeier; Kate L. Perry; Elena L. Harden; Jana Stasakova; Veronika Jenei; Jason Fleming; Oliver Wood; Jeongmin Woo; Christopher H. Woelk; Gareth J. Thomas; Stephen M. Thirdborough
View articletitled, Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Supplementary data
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Molecular and Cellular Pathobiology

Author Choice
Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression
Sandeep K. Botla; Soniya Savant; Pouria Jandaghi; Andrea S. Bauer; Oliver Mücke; Evgeny A. Moskalev; John P. Neoptolemos; Eithne Costello; William Greenhalf; Aldo Scarpa; Matthias M. Gaida; Markus W. Büchler; Oliver Strobel; Thilo Hackert; Nathalia A. Giese; Hellmut G. Augustin; Jörg D. Hoheisel
View articletitled, Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression
Supplementary data
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miR-29b Mediates NF-κB Signaling in KRAS-Induced Non–Small Cell Lung Cancers
Stephanie Langsch; Ulrich Baumgartner; Stefan Haemmig; Cornelia Schlup; Stephan C. Schäfer; Sabina Berezowska; Gregor Rieger; Patrick Dorn; Mario P. Tschan; Erik Vassella
View articletitled, miR-29b Mediates NF-κB Signaling in KRAS-Induced Non–Small Cell Lung Cancers
Supplementary data
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S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
Salvatore Rizza; Costanza Montagna; Simone Cardaci; Emiliano Maiani; Giuseppina Di Giacomo; Virginia Sanchez-Quiles; Blagoy Blagoev; Andrea Rasola; Daniela De Zio; Jonathan S. Stamler; Francesco Cecconi; Giuseppe Filomeni
View articletitled, <em>S</em>-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
Supplementary data
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Author Choice
A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies
Yongliang Zhang; Jennifer T. Fox; Young-Un Park; Gene Elliott; Ganesha Rai; Mengli Cai; Srilatha Sakamuru; Ruili Huang; Menghang Xia; Kyeryoung Lee; Min Ho Jeon; Bijoy P. Mathew; Hee Dong Park; Winfried Edelmann; Chan Young Park; Sung You Hong; David Maloney; Kyungjae Myung
View articletitled, A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies
Supplementary data
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Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Shinya Sato; Keisuke Katsushima; Keiko Shinjo; Akira Hatanaka; Fumiharu Ohka; Shugo Suzuki; Aya Naiki-Ito; Norihito Soga; Satoru Takahashi; Yutaka Kondo
View articletitled, Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Supplementary data
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Author Choice
Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma
Ke Li; Baiyong Shen; Xi Cheng; Ding Ma; Xiaoqian Jing; Xinyu Liu; Weiping Yang; Chenghong Peng; Weihua Qiu
View articletitled, Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma
Supplementary data
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Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer
Daniele Viarisio; Karin Müller-Decker; Paola Zanna; Ulrich Kloz; Birgit Aengeneyndt; Rosita Accardi; Christa Flechtenmacher; Lutz Gissmann; Massimo Tommasino
View articletitled, Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer
Supplementary data
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Prevention and Epidemiology

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial
Catherine Duggan; Jean de Dieu Tapsoba; Ching-Yun Wang; Anne McTiernan
View articletitled, Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial
Supplementary data
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Therapeutics, Targets, and Chemical Biology

The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling
Mariam Mansour; Sue Haupt; Ai-Leen Chan; Nathan Godde; Alexandra Rizzitelli; Sherene Loi; Franco Caramia; Siddhartha Deb; Elena A. Takano; Mark Bishton; Cameron Johnstone; Brendon Monahan; Yarra Levav-Cohen; Yong-Hui Jiang; Alpha S. Yap; Stephen Fox; Ora Bernard; Robin Anderson; Ygal Haupt
View articletitled, The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling
Supplementary data
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Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Moran Grossman; Nir Ben-Chetrit; Alina Zhuravlev; Ran Afik; Elad Bassat; Inna Solomonov; Yosef Yarden; Irit Sagi
View articletitled, Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Supplementary data
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Author Choice
Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target
Geoffrey Grandjean; Petrus R. de Jong; Brian P. James; Mei Yee Koh; Robert Lemos; John Kingston; Alexander Aleshin; Laurie A. Bankston; Claudia P. Miller; Eun Jeong Cho; Ramakrishna Edupuganti; Ashwini Devkota; Gabriel Stancu; Robert C. Liddington; Kevin N. Dalby; Garth Powis
View articletitled, Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target
Supplementary data
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Tumor and Stem Cell Biology

Tissue Factor Induced by Epithelial–Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells
Morgane Bourcy; Meggy Suarez-Carmona; Justine Lambert; Marie-Emilie Francart; Hélène Schroeder; Céline Delierneux; Nicolas Skrypek; Erik W. Thompson; Guy Jérusalem; Geert Berx; Marc Thiry; Silvia Blacher; Brett G. Hollier; Agnès Noël; Cécile Oury; Myriam Polette; Christine Gilles
View articletitled, Tissue Factor Induced by Epithelial–Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells
Supplementary data
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MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages
Kazuya Yamada; Akihiko Uchiyama; Akihito Uehara; Buddhini Perera; Sachiko Ogino; Yoko Yokoyama; Yuko Takeuchi; Mark C. Udey; Osamu Ishikawa; Sei-ichiro Motegi
View articletitled, MFG-E8 Drives Melanoma Growth by Stimulating Mesenchymal Stromal Cell–Induced Angiogenesis and M2 Polarization of Tumor-Associated Macrophages
Supplementary data
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miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis
Jianfei Xue; Aidong Zhou; Yamei Wu; Saint-Aaron Morris; Kangyu Lin; Samirkumar Amin; Roeland Verhaak; Gregory Fuller; Keping Xie; Amy B. Heimberger; Suyun Huang
View articletitled, miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis
Supplementary data
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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