Epithelial–mesenchymal transition induces tissue factor expression and coagulant properties that drive early metastasis of circulating tumor cells. Using immunofluorescence, vimentin-expressing tumor cells (red) surrounded by platelet-rich microthrombi (blue) were observed colonizing lungs in experimental models of metastasis (nuclei, white). For details, see article by Bourcy and colleagues on page 4270.