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1 June 2016
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Myeloid-derived suppressor cells (MDSC) inhibit tumor immunity, prompt breast cancer stemness, and enhance tumorigenic potential. Mechanistically, MDSC-derived IL6 initiates STAT3 phosphorylation, and MDSC-derived nitric oxide activates NOTCH and NOTCH subsequently and collaboratively acts with IL6 to promote prolonged STAT3 activation. Using immunofluorescence, it was found that MDSCs increased ALDH1 expression in tumor cells. For details, see article by Peng and colleagues on page 3156.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Cancer Research 75th Anniversary Commentaries
Review
Perspective
Priority Report
PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers
David P. Labbé; Noriko Uetani; Valérie Vinette; Laurent Lessard; Isabelle Aubry; Eva Migon; Jacinthe Sirois; Jody J. Haigh; Louis R. Bégin; Lloyd C. Trotman; Marilène Paquet; Michel L. Tremblay
Integrated Systems and Technologies
Microenvironment and Immunology
Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Dongjun Peng; Takashi Tanikawa; Wei Li; Lili Zhao; Linda Vatan; Wojciech Szeliga; Shanshan Wan; Shuang Wei; Yin Wang; Yan Liu; Elzbieta Staroslawska; Franciszek Szubstarski; Jacek Rolinski; Ewelina Grywalska; Andrzej Stanisławek; Wojciech Polkowski; Andrzej Kurylcio; Celina Kleer; Alfred E. Chang; Max Wicha; Michael Sabel; Weiping Zou; Ilona Kryczek
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Majken Wallerius; Tatjana Wallmann; Margarita Bartish; Jeanette Östling; Artur Mezheyeuski; Nicholas P. Tobin; Emma Nygren; Pradeepa Pangigadde; Paola Pellegrini; Mario Leonardo Squadrito; Fredrik Pontén; Johan Hartman; Jonas Bergh; Angelo De Milito; Michele De Palma; Arne Östman; John Andersson; Charlotte Rolny
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Mauricio S. Caetano; Huiyuan Zhang; Amber M. Cumpian; Lei Gong; Nese Unver; Edwin J. Ostrin; Soudabeh Daliri; Seon Hee Chang; Cesar E. Ochoa; Samir Hanash; Carmen Behrens; Ignacio I. Wistuba; Cinthya Sternberg; Humam Kadara; Carlos Gil Ferreira; Stephanie S. Watowich; Seyed Javad Moghaddam
Molecular and Cellular Pathobiology
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth
Rajneesh Pathania; Sabarish Ramachandran; Gurusamy Mariappan; Priyanka Thakur; Huidong Shi; Jeong-Hyeon Choi; Santhakumar Manicassamy; Ravindra Kolhe; Puttur D. Prasad; Suash Sharma; Bal L. Lokeshwar; Vadivel Ganapathy; Muthusamy Thangaraju
ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis
Lidia Rodriguez Calleja; Camille Jacques; François Lamoureux; Marc Baud'huin; Marta Tellez Gabriel; Thibaut Quillard; Debashish Sahay; Pierre Perrot; Jerome Amiaud; Celine Charrier; Regis Brion; Fernando Lecanda; Franck Verrecchia; Dominique Heymann; Leif W. Ellisen; Benjamin Ory
Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Hidenari Hirata; Keishi Sugimachi; Hisateru Komatsu; Masami Ueda; Takaaki Masuda; Ryutaro Uchi; Shotaro Sakimura; Sho Nambara; Tomoko Saito; Yoshiaki Shinden; Tomohiro Iguchi; Hidetoshi Eguchi; Shuhei Ito; Kotaro Terashima; Katsumi Sakamoto; Masakazu Hirakawa; Hiroshi Honda; Koshi Mimori
Prevention and Epidemiology
Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3
Meilin Wang; Zhiqiang Li; Haiyan Chu; Qiang Lv; Dingwei Ye; Qiang Ding; Chuanliang Xu; Jianming Guo; Mulong Du; Jianhua Chen; Zhijian Song; Changjun Yin; Chao Qin; Chengyuan Gu; Yao Zhu; Guowei Xia; Fang Liu; Zhengsheng Zhang; Lin Yuan; Guangbo Fu; Zhibin Hu; Na Tong; Jiawei Shen; Ke Liu; Jielin Sun; Yinghao Sun; Jue Li; Xingwang Li; Hongbing Shen; Jianfeng Xu; Yongyong Shi; Zhengdong Zhang
Therapeutics, Targets, and Chemical Biology
AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor–Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment
Natalie A. Daurio; Stephen W. Tuttle; Andrew J. Worth; Ethan Y. Song; Julianne M. Davis; Nathaniel W. Snyder; Ian A. Blair; Constantinos Koumenis
Author Choice
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Hazel M. Weir; Robert H. Bradbury; Mandy Lawson; Alfred A. Rabow; David Buttar; Rowena J. Callis; Jon O. Curwen; Camila de Almeida; Peter Ballard; Michael Hulse; Craig S. Donald; Lyman J.L. Feron; Galith Karoutchi; Philip MacFaul; Thomas Moss; Richard A. Norman; Stuart E. Pearson; Michael Tonge; Gareth Davies; Graeme E. Walker; Zena Wilson; Rachel Rowlinson; Steve Powell; Claire Sadler; Graham Richmond; Brendon Ladd; Ermira Pazolli; Anne Marie Mazzola; Celina D'Cruz; Chris De Savi
Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Dashnamoorthy Ravi; Afshin Beheshti; Nasséra Abermil; Frank Passero; Jaya Sharma; Michael Coyle; Athena Kritharis; Irawati Kandela; Lynn Hlatky; Michail V. Sitkovsky; Andrew Mazar; Ronald B. Gartenhaus; Andrew M. Evens
Sustained Accumulation of Microtubule-Binding Chemotherapy Drugs in the Peripheral Nervous System: Correlations with Time Course and Neurotoxic Severity
Krystyna M. Wozniak; James J. Vornov; Ying Wu; Kenichi Nomoto; Bruce A. Littlefield; Christopher DesJardins; Yanke Yu; George Lai; Larisa Reyderman; Nancy Wong; Barbara S. Slusher
Author Choice
Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma
Sergei Vatolin; James G. Phillips; Babal K. Jha; Shravya Govindgari; Jennifer Hu; Dale Grabowski; Yvonne Parker; Daniel J. Lindner; Fei Zhong; Clark W. Distelhorst; Mitchell R. Smith; Claudiu Cotta; Yan Xu; Sujatha Chilakala; Rebecca R. Kuang; Samantha Tall; Frederic J. Reu
Tumor and Stem Cell Biology
p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia
Audrey M. Hendley; Yue J. Wang; Kishore Polireddy; Janivette Alsina; Ishrat Ahmed; Kelly J. Lafaro; Hao Zhang; Nilotpal Roy; Samuel G. Savidge; Yanna Cao; Matthias Hebrok; Anirban Maitra; Albert B. Reynolds; Michael Goggins; Mamoun Younes; Christine A. Iacobuzio-Donahue; Steven D. Leach; Jennifer M. Bailey
Correction
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