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miR340 is a tumor suppressor whose overexpression in human glioma-intiating cells (GIC) inhibits their proliferation, invasive, and migratory properties. Transplantation of miR340-overexpressed GICs in NOD/SCID mouse brains completely suppressed the tumor formation of malignant gliomas. Among factors related to antitumorigenesis, the transplanted GICs with miR340 overexpression showed a positive immunostain for an active form of caspase-3 in the early stage of transplantation, suggesting that antitumorigenic activity of miR340 in GICs may be due to tumor cell apoptosis. For details, see the article by Yamashita and colleagues on page 1123. - PDF Icon PDF LinkTable of Contents
Cancer Research
Table of Contents
Breaking Advances
Reviews
Perspective
Meeting Report
Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance
Integrated Systems and Technologies
Microenvironment and Immunology
CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy
RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment
Molecular and Cellular Pathobiology
Coordinate Loss of MAP3K7 and CHD1 Promotes Aggressive Prostate Cancer
Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate
Therapeutics, Targets, and Chemical Biology
Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Tumor and Stem Cell Biology
Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion
Letters to the Editor
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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