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15 July 2015
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In normal epithelial cells, there is a balance of pro- and antiangiogenic and lymphangiogenic factors maintaining proper tissue homeostasis. During malignant transformation, early loss of one such factor, the lymphatic endothelial cell inhibitor SEMA3F, is necessary to enable pathologic lymphangiogenesis. As the squamous cell carcinoma cells develop a more aggressive phenotype, acquired expression of surface receptors like neuropilin 2 (NRP2), a receptor typically expressed at high levels on lymphatic endothelial cells, further facilitate tumor vascularity, expansion, and metastatic spread. Thus, expression of SEMA3F may function in both an autocrine and paracrine fashion through NRP2 to inhibit tumor growth, lymphatic invasion, and metastasis. For details, see article by Doçi and colleagues on page 2937.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Microenvironment and Immunology
Breast Cancer Cell–Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes
Cristina Ghirelli; Fabien Reyal; Marine Jeanmougin; Raphaël Zollinger; Philémon Sirven; Paula Michea; Christophe Caux; Nathalie Bendriss-Vermare; Marie-Hélène Donnadieu; Martial Caly; Virginie Fourchotte; Anne Vincent-Salomon; Brigitte Sigal-Zafrani; Xavier Sastre-Garau; Vassili Soumelis
Author Choice
NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay
Lisa A. Ridnour; Robert Y.S. Cheng; Jonathan M. Weiss; Sukhbir Kaur; David R. Soto-Pantoja; Debashree Basudhar; Julie L. Heinecke; C. Andrew Stewart; William DeGraff; Anastasia L. Sowers; Angela Thetford; Aparna H. Kesarwala; David D. Roberts; Howard A. Young; James B. Mitchell; Giorgio Trinchieri; Robert H. Wiltrout; David A. Wink
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Albert Lo; Liang-Chuan S. Wang; John Scholler; James Monslow; Diana Avery; Kheng Newick; Shaun O'Brien; Rebecca A. Evans; David J. Bajor; Cynthia Clendenin; Amy C. Durham; Elizabeth L. Buza; Robert H. Vonderheide; Carl H. June; Steven M. Albelda; Ellen Puré
Author Choice
Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Ashley Browne; Laura A. Tookman; Carin K. Ingemarsdotter; Russell D. Bouwman; Katrina Pirlo; Yaohe Wang; Iain A. McNeish; Michelle Lockley
Molecular and Cellular Pathobiology
TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia
Jumpei Yamazaki; Jaroslav Jelinek; Yue Lu; Matteo Cesaroni; Jozef Madzo; Frank Neumann; Rong He; Rodolphe Taby; Aparna Vasanthakumar; Trisha Macrae; Kelly R. Ostler; Hagop M. Kantarjian; Shoudan Liang; Marcos R. Estecio; Lucy A. Godley; Jean-Pierre J. Issa
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Author Choice
Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade
Santosh Kumar Guru; Anup Singh Pathania; Suresh Kumar; Deshidi Ramesh; Manjeet Kumar; Satiander Rana; Ajay Kumar; Fayaz Malik; P.R. Sharma; B.K. Chandan; Sundeep Jaglan; J.P. Sharma; Bhahwal Ali Shah; Sheikh Abdullah Tasduq; Surrinder K. Lattoo; Abdul Faruk; A.K. Saxena; R.A. Vishwakarma; Shashi Bhushan
Evidence Suggesting That Discontinuous Dosing of ALK Kinase Inhibitors May Prolong Control of ALK+ Tumors
Amit Dipak Amin; Soumya S. Rajan; Winnie S. Liang; Praechompoo Pongtornpipat; Matthew J. Groysman; Edgar O. Tapia; Tara L. Peters; Lori Cuyugan; Jonathan Adkins; Lisa M. Rimsza; Yves A. Lussier; Soham D. Puvvada; Jonathan H. Schatz
Tumor and Stem Cell Biology
Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Chun-Jung Ko; Cheng-Chung Huang; Hsin-Ying Lin; Chun-Pai Juan; Shao-Wei Lan; Hsin-Yi Shyu; Shang-Ru Wu; Pei-Wen Hsiao; Hsiang-Po Huang; Chia-Tung Shun; Ming-Shyue Lee
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