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Ultrasound is a complementary imaging modality for detection of mammographically occult breast cancers, especially in patients with dense breast tissue. Diagnostic accuracy of ultrasound in these patients can be significantly improved using contrast agents targeted at molecular signatures on the tumor neovasculature. In a large scale immunohistochemcical staining analysis of human tissues, it was found that B7-H3 is differentially expressed in breast cancer–associated vascular endothelial cells compared with normal, benign, and precursor lesions. Also, B7-H3-targeted ultrasound molecular imaging allowed detection of breast cancer in a transgenic mouse model of breast cancer development. For details, see article by Bachawal and colleagues on page 2501. - PDF Icon PDF LinkTable of Contents
Cancer Research
Table of Contents
Breaking Advances
Reviews
Integrated Systems and Technologies
Microenvironment and Immunology
Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer
Prevention and Epidemiology
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures
Therapeutics, Targets, and Chemical Biology
Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death
Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models
Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids
Tumor and Stem Cell Biology
Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State
Corrections
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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