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15 May 2015
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Cover Image
Pelvic lymph nodes are the most frequent sites of prostate cancer dissemination, as depicted here by pan-cytokeratin immunohistochemistry on a human specimen. However, there is little knowledge about how precociously disseminated cancer cells seed lymph nodes and protect themselves from immune surveillance. Jachetti and colleagues report that early-disseminating cancer stem-like cells seed quiescent future sites of metastasis in tumor-draining lymph nodes by engaging Tenascin-C, a protumorigenic extracellular matrix protein, which mediates local immune escape by arresting T lymphocyte activation. For details, see article by Jachetti and colleagues on page 2095.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Priority Reports
PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Chen-Lin Hsieh; Ginevra Botta; Shuai Gao; Tiantian Li; Eliezer M. Van Allen; Daniel J. Treacy; Changmeng Cai; Housheng Hansen He; Christopher J. Sweeney; Myles Brown; Steven P. Balk; Peter S. Nelson; Levi A. Garraway; Philip W. Kantoff
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Author Choice
The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion via a CXCL Signaling Module
Ke Chen; Kongming Wu; Xuanmao Jiao; Liping Wang; Xiaoming Ju; Min Wang; Gabriele Di Sante; Shaohua Xu; Qiong Wang; Kevin Li; Xin Sun; Congwen Xu; Zhiping Li; Mathew C. Casimiro; Adam Ertel; Sankar Addya; Peter A. McCue; Michael P. Lisanti; Chenguang Wang; Richard J. Davis; Graeme Mardon; Richard G. Pestell
Therapeutics, Targets, and Chemical Biology
Author Choice
CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110
Shanhu Hu; Alexey V. Danilov; Kristina Godek; Bernardo Orr; Laura J. Tafe; Jaime Rodriguez-Canales; Carmen Behrens; Barbara Mino; Cesar A. Moran; Vincent A. Memoli; Lisa Maria Mustachio; Fabrizio Galimberti; Saranya Ravi; Andrew DeCastro; Yun Lu; David Sekula; Angeline S. Andrew; Ignacio I. Wistuba; Sarah Freemantle; Duane A. Compton; Ethan Dmitrovsky
Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Nassir M. Mansour; Giovanna M. Bernal; Longtao Wu; Clayton D. Crawley; Kirk E. Cahill; David J. Voce; Irina V. Balyasnikova; Wei Zhang; Ruben Spretz; Luis Nunez; Gustavo F. Larsen; Ralph R. Weichselbaum; Bakhtiar Yamini
Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB
Zhiping Zeng; Zhe Sun; Mingfeng Huang; Weidong Zhang; Jie Liu; Liqun Chen; Fan Chen; Yuqi Zhou; Jiacheng Lin; Fengyu Huang; Lin Xu; Zixing Zhuang; Shangjie Guo; Gulimiran Alitongbieke; Guobin Xie; Yang Xu; Bingzhen Lin; Xihua Cao; Ying Su; Xiao-kun Zhang; Hu Zhou
Author Choice
Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors
Noah A. Cohen; Shan Zeng; Adrian M. Seifert; Teresa S. Kim; Eric C. Sorenson; Jonathan B. Greer; Michael J. Beckman; Juan A. Santamaria-Barria; Megan H. Crawley; Benjamin L. Green; Ferdinand Rossi; Peter Besmer; Cristina R. Antonescu; Ronald P. DeMatteo
Tumor and Stem Cell Biology
MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Olga Tatti; Erika Gucciardo; Pirita Pekkonen; Tanja Holopainen; Riku Louhimo; Pauliina Repo; Pilvi Maliniemi; Jouko Lohi; Ville Rantanen; Sampsa Hautaniemi; Kari Alitalo; Annamari Ranki; Päivi M. Ojala; Jorma Keski-Oja; Kaisa Lehti
Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation
Elena Jachetti; Sara Caputo; Stefania Mazzoleni; Chiara Svetlana Brambillasca; Sara Martina Parigi; Matteo Grioni; Ignazio Stefano Piras; Umberto Restuccia; Arianna Calcinotto; Massimo Freschi; Angela Bachi; Rossella Galli; Matteo Bellone
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Stefan Klingler; Baofeng Guo; Jun Yao; Haiyan Yan; Ling Zhang; Angelina V. Vaseva; Sida Chen; Peter Canoll; James W. Horner; Y. Alan Wang; Ji-Hye Paik; Haoqiang Ying; Hongwu Zheng
Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer
Monther Abu-Remaileh; Sebastian Bender; Günter Raddatz; Ihab Ansari; Daphne Cohen; Julian Gutekunst; Tanja Musch; Heinz Linhart; Achim Breiling; Eli Pikarsky; Yehudit Bergman; Frank Lyko
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