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1 May 2014
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Aberrant expression of the T-box transcription factor brachyury in human carcinomas drives the phenomenon of epithelial-mesenchymal transition (EMT), a phenotypic modulation that facilitates tumor dissemination and resistance to conventional anti-neoplastic therapies. Hamilton and colleagues show that acquisition of a mesenchymal-like phenotype could also significantly reduce the susceptibility of cancer cells to lysis by both antigen-specific T cells and natural killer cells. This defect was observed even in the presence of a stable engagement between the immune effector cells and the tumor cells, as demonstrated by the effective polar actin polymerization observed at the interacting surface area. The phenomenon of immune resistance of mesenchymal-like cells was correlated to their decreased levels of cell cycle kinase CDK1, a defect that could be countered by treatment with a specific inhibitor of WEE1. For details, see article by Hamilton and colleagues on page 2510.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Priority Report
Integrated Systems and Technologies
Microenvironment and Immunology
Endothelial-Specific Notch Blockade Inhibits Vascular Function and Tumor Growth through an eNOS-Dependent Mechanism
Alexandre Patenaude; Megan Fuller; Linda Chang; Fred Wong; Grigorios Paliouras; Rebecca Shaw; Alastair H. Kyle; Patricia Umlandt; Jennifer H.E. Baker; Erika Diaz; Jade Tong; Andrew I. Minchinton; Aly Karsan
Molecular and Cellular Pathobiology
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
Warren Fiskus; Nakhle Saba; Min Shen; Mondana Ghias; Jinyun Liu; Soumyasri Das Gupta; Lata Chauhan; Rekha Rao; Sumedha Gunewardena; Kevin Schorno; Christopher P. Austin; Kami Maddocks; John Byrd; Ari Melnick; Peng Huang; Adrian Wiestner; Kapil N. Bhalla
STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious
Paola Maycotte; Christy M. Gearheart; Rebecca Barnard; Suraj Aryal; Jean M. Mulcahy Levy; Susan P. Fosmire; Ryan J. Hansen; Michael J. Morgan; Christopher C. Porter; Daniel L. Gustafson; Andrew Thorburn
Tumor and Stem Cell Biology
Author Choice
Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
Burkhard Kneitz; Markus Krebs; Charis Kalogirou; Maria Schubert; Steven Joniau; Hein van Poppel; Evelyne Lerut; Susanne Kneitz; Claus Jürgen Scholz; Philipp Ströbel; Manfred Gessler; Hubertus Riedmiller; Martin Spahn
GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3
Johannes Fabian; Marco Lodrini; Ina Oehme; Marie C. Schier; Theresa M. Thole; Thomas Hielscher; Annette Kopp-Schneider; Lennart Opitz; David Capper; Andreas von Deimling; Inga Wiegand; Till Milde; Ulrich Mahlknecht; Frank Westermann; Odilia Popanda; Frederik Roels; Barbara Hero; Frank Berthold; Matthias Fischer; Andreas E. Kulozik; Olaf Witt; Hedwig E. Deubzer
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