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Aberrant expression of the T-box transcription factor brachyury in human carcinomas drives the phenomenon of epithelial-mesenchymal transition (EMT), a phenotypic modulation that facilitates tumor dissemination and resistance to conventional anti-neoplastic therapies. Hamilton and colleagues show that acquisition of a mesenchymal-like phenotype could also significantly reduce the susceptibility of cancer cells to lysis by both antigen-specific T cells and natural killer cells. This defect was observed even in the presence of a stable engagement between the immune effector cells and the tumor cells, as demonstrated by the effective polar actin polymerization observed at the interacting surface area. The phenomenon of immune resistance of mesenchymal-like cells was correlated to their decreased levels of cell cycle kinase CDK1, a defect that could be countered by treatment with a specific inhibitor of WEE1. For details, see article by Hamilton and colleagues on page 2510. - PDF Icon PDF LinkTable of Contents
Cancer Research
Table of Contents
Breaking Advances
Review
Priority Report
Integrated Systems and Technologies
Microenvironment and Immunology
Endothelial-Specific Notch Blockade Inhibits Vascular Function and Tumor Growth through an eNOS-Dependent Mechanism
Molecular and Cellular Pathobiology
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious
Tumor and Stem Cell Biology
Survival in Patients with High-Risk Prostate Cancer Is Predicted by miR-221, Which Regulates Proliferation, Apoptosis, and Invasion of Prostate Cancer Cells by Inhibiting IRF2 and SOCS3
GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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