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Volume 74, Issue 6

15 March 2014

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Cover Image

Cover Image

Pancreas from a 12-week-old KPCT (p48-Cre; LSL-Kras^G12D; p53^Lox/7+; Rosa26-LSL-tdTomato) mouse with precancerous PanIN lesions but no tumor. dtTomato-label (red) marks pancreas epithelial-derived cells, in this case normal-appearing acinar cells. PGP 9.5 antibody (green) was used to stain nerve fibers that exhibit hypertrophy and sprouting within pancreatic tissue, beginning at histologic precancer stages and increasing as the disease progresses. For details, see article by Stopczynski and colleagues on page 1718.
Table of Contents

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Advances
Reviews
Priority Reports
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology
Correction

Cancer Research

Breaking Advances

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Reviews

Contributions of the Host Microenvironment to Cancer-Induced Bone Disease

Sam W.Z. Olechnowicz; Claire M. Edwards

Abstract

View articletitled, Contributions of the Host Microenvironment to Cancer-Induced Bone Disease

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Optimization of Natural Killer T Cell–Mediated Immunotherapy in Cancer Using Cell-Based and Nanovector Vaccines

C. Faveeuw; F. Trottein

Abstract

View articletitled, Optimization of Natural Killer T Cell–Mediated Immunotherapy in Cancer Using Cell-Based and Nanovector Vaccines

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Author Choice

Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

Yinghui Li; Vinay Tergaonkar

Abstract

View articletitled, Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies

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Priority Reports

Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells

Arun Satelli; Abhisek Mitra; Jeffry J. Cutrera; Marcos Devarie; Xueqing Xia; Davis R. Ingram; Denada Dibra; Neeta Somaiah; Keila E. Torres; Vinod Ravi; Joseph A. Ludwig; Eugenie S. Kleinerman; Shulin Li

Abstracts

View articletitled, Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells

Supplementary data

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PCAT-1, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

John R. Prensner; Wei Chen; Matthew K. Iyer; Qi Cao; Teng Ma; Sumin Han; Anirban Sahu; Rohit Malik; Kari Wilder-Romans; Nora Navone; Christopher J. Logothetis; John C. Araujo; Louis L. Pisters; Ashutosh K. Tewari; Christine E. Canman; Karen E. Knudsen; Naoki Kitabayashi; Mark A. Rubin; Francesca Demichelis; Theodore S. Lawrence; Arul M. Chinnaiyan; Felix Y. Feng

Abstracts

View articletitled, <em>PCAT-1</em>, a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

Supplementary data

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Integrated Systems and Technologies

Cancer-Associated Mutations in Healthy Individuals: Assessing the Risk of Carcinogenesis

Ignacio A. Rodriguez-Brenes; Natalia L. Komarova; Dominik Wodarz

Abstracts

View articletitled, Cancer-Associated Mutations in Healthy Individuals: Assessing the Risk of Carcinogenesis

Supplementary data

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Microenvironment and Immunology

Author Choice

Identification of Immune Factors Regulating Antitumor Immunity Using Polymeric Vaccines with Multiple Adjuvants

Omar A. Ali; Catia Verbeke; Chris Johnson; R. Warren Sands; Sarah A. Lewin; Des White; Edward Doherty; Glenn Dranoff; David J. Mooney

Abstracts

View articletitled, Identification of Immune Factors Regulating Antitumor Immunity Using Polymeric Vaccines with Multiple Adjuvants

Supplementary data

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Molecular and Cellular Pathobiology

Author Choice

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

Aifu Lin; Hai-long Piao; Li Zhuang; Dos D. Sarbassov; Li Ma; Boyi Gan

Abstracts

View articletitled, FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

Supplementary data

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Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer

Gunnar Steinert; Sebastian Schölch; Thomas Niemietz; Naoki Iwata; Sebastián A. García; Bianca Behrens; Anita Voigt; Matthias Kloor; Axel Benner; Ulrich Bork; Nuh N. Rahbari; Markus W. Büchler; Nikolas H. Stoecklein; Jürgen Weitz; Moritz Koch

Abstracts

View articletitled, Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer

Supplementary data

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UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim; Amrish Sharma; Shilpa S. Dhar; Sung-Hun Lee; Bingnan Gu; Chia-Hsin Chan; Hui-Kuan Lin; Min Gyu Lee

Abstracts

View articletitled, UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Supplementary data

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Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

Rachelle E. Stopczynski; Daniel P. Normolle; Douglas J. Hartman; Haoqiang Ying; Jennifer J. DeBerry; Klaus Bielefeldt; Andrew D. Rhim; Ronald A. DePinho; Kathryn M. Albers; Brian M. Davis

Abstracts

View articletitled, Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

Supplementary data

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HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKT

Ji Heon Noh; Hyun Jin Bae; Jung Woo Eun; Qingyu Shen; Se Jin Park; Hyung Seok Kim; Boas Nam; Woo Chan Shin; Eun Kyung Lee; Kyungbun Lee; Ja-Jun Jang; Won Sang Park; Jung Young Lee; Suk Woo Nam

Abstracts

View articletitled, HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKT

Supplementary data

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p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors

Rüveyda Dok; Peter Kalev; Evert Jan Van Limbergen; Layka Abbasi Asbagh; Iria Vázquez; Esther Hauben; Anna Sablina; Sandra Nuyts

Abstracts

View articletitled, p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors

Supplementary data

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Therapeutics, Targets, and Chemical Biology

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Fengting Yan; Lapo Alinari; Mark E. Lustberg; Ludmila Katherine Martin; Hector M. Cordero-Nieves; Yeshavanth Banasavadi-Siddegowda; Selene Virk; Jill Barnholtz-Sloan; Erica Hlavin Bell; Jeffrey Wojton; Naduparambil K. Jacob; Arnab Chakravarti; Michal O. Nowicki; Xin Wu; Rosa Lapalombella; Jharna Datta; Bo Yu; Kate Gordon; Amy Haseley; John T. Patton; Porsha L. Smith; John Ryu; Xiaoli Zhang; Xiaokui Mo; Guido Marcucci; Gerard Nuovo; Chang-Hyuk Kwon; John C. Byrd; E. Antonio Chiocca; Chenglong Li; Said Sif; Samson Jacob; Sean Lawler; Balveen Kaur; Robert A. Baiocchi

Abstracts

View articletitled, Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Supplementary data

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Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway

Rosa Martín-Pérez; Carmen Palacios; Rosario Yerbes; Ana Cano-González; Daniel Iglesias-Serret; Joan Gil; Mauricio J. Reginato; Abelardo López-Rivas

Abstracts

View articletitled, Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway

Supplementary data

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Author Choice

ATDC/TRIM29 Phosphorylation by ATM/MAPKAP Kinase 2 Mediates Radioresistance in Pancreatic Cancer Cells

Lidong Wang; Huibin Yang; Phillip L. Palmbos; Gina Ney; Taylor Ann Detzler; Dawn Coleman; Jacob Leflein; Mary Davis; Min Zhang; Wenhua Tang; J. Kevin Hicks; Corey M. Helchowski; Jayendra Prasad; Theodore S. Lawrence; Liang Xu; Xiaochun Yu; Christine E. Canman; Mats Ljungman; Diane M. Simeone

Abstracts

View articletitled, ATDC/TRIM29 Phosphorylation by ATM/MAPKAP Kinase 2 Mediates Radioresistance in Pancreatic Cancer Cells

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Author Choice

Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity

Daniel O. Villarreal; Megan C. Wise; Jewell N. Walters; Emma L. Reuschel; Min Joung Choi; Nyamekye Obeng-Adjei; Jian Yan; Matthew P. Morrow; David B. Weiner

Abstracts

View articletitled, Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity

Supplementary data

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miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway

Jian-Jun Zhao; Jianhong Lin; Di Zhu; Xujun Wang; Daniel Brooks; Ming Chen; Zhang-Bo Chu; Kohichi Takada; Bryan Ciccarelli; Samir Admin; Jianguo Tao; Yu-Tzu Tai; Steven Treon; Geraldine Pinkus; Winston Patrick Kuo; Teru Hideshima; Mary Bouxsein; Nikhil Munshi; Kenneth Anderson; Ruben Carrasco

Abstracts

View articletitled, miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway

Supplementary data

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Tumor and Stem Cell Biology

Author Choice

Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions

Lawrence N. Kwong; Lynda Chin

Abstracts

View articletitled, Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions

Supplementary data

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Id2 Mediates Oligodendrocyte Precursor Cell Maturation Arrest and Is Tumorigenic in a PDGF-Rich Microenvironment

Matthew C. Havrda; Brenton R. Paolella; Cong Ran; Karola S. Jering; Christina M. Wray; Jaclyn M. Sullivan; Audrey Nailor; Yasuyuki Hitoshi; Mark A. Israel

Abstracts

View articletitled, Id2 Mediates Oligodendrocyte Precursor Cell Maturation Arrest and Is Tumorigenic in a PDGF-Rich Microenvironment

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Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

Rebecca Favaro; Irene Appolloni; Serena Pellegatta; Alexandra Badiola Sanga; Pierfrancesco Pagella; Eleonora Gambini; Federica Pisati; Sergio Ottolenghi; Maria Foti; Gaetano Finocchiaro; Paolo Malatesta; Silvia K. Nicolis

Abstracts

View articletitled, Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

Supplementary data

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Author Choice

Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma

Jian Hong; Yunfei Yuan; Jianping Wang; Yadi Liao; Ruhai Zou; Chuanlong Zhu; Binkui Li; Yi Liang; Pinzhu Huang; Zongwei Wang; Wenyu Lin; Yixin Zeng; Jia Le Dai; Raymond T. Chung

Abstracts

View articletitled, Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma

Supplementary data

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MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

Paolo Luraghi; Gigliola Reato; Elia Cipriano; Francesco Sassi; Francesca Orzan; Viola Bigatto; Francesca De Bacco; Elena Menietti; May Han; William M. Rideout, III; Timothy Perera; Andrea Bertotti; Livio Trusolino; Paolo M. Comoglio; Carla Boccaccio

Abstracts

View articletitled, MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

Supplementary data

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p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

Jian Zhong; Liya Ding; Laura R. Bohrer; Yunqian Pan; Ping Liu; Jun Zhang; Thomas J. Sebo; R. Jeffrey Karnes; Donald J. Tindall; Jan van Deursen; Haojie Huang

Abstracts

View articletitled, p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

Supplementary data

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Correction

Correction: EPR Oxygen Images Predict Tumor Control by a 50% Tumor Control Radiation Dose

Extract

View articletitled, Correction: EPR Oxygen Images Predict Tumor Control by a 50% Tumor Control Radiation Dose

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cover Image

Cancer Research

Table of Contents

Breaking Advances

Reviews

Priority Reports

Integrated Systems and Technologies

Microenvironment and Immunology

Molecular and Cellular Pathobiology

Therapeutics, Targets, and Chemical Biology

Tumor and Stem Cell Biology

Correction

Journal Archive

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