Myostatin gene inactivation drastically reduces the development of polyposis in Apc^Min/+ mouse. The Apc^Min/+ mouse has a mutation in the adenomatous polyposis coli (Apc) tumor suppressor gene, which is responsible for the development of colorectal cancer and cachexia. Myostatin is a master negative regulator of skeletal muscle mass. It was found that inactivation of the myostatin gene on the Apc^Min/+ genetic background, a condition that completely prevents cancer cachexia, strikingly reduced the number and size of intestinal polyps. For details see article by Gallot and colleagues on page 7344.