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15 December 2014
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Myostatin gene inactivation drastically reduces the development of polyposis in ApcMin/+ mouse. The ApcMin/+ mouse has a mutation in the adenomatous polyposis coli (Apc) tumor suppressor gene, which is responsible for the development of colorectal cancer and cachexia. Myostatin is a master negative regulator of skeletal muscle mass. It was found that inactivation of the myostatin gene on the ApcMin/+ genetic background, a condition that completely prevents cancer cachexia, strikingly reduced the number and size of intestinal polyps. For details see article by Gallot and colleagues on page 7344.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Perspectives
Priority Reports
Author Choice
AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Carmen Priolo; Saumyadipta Pyne; Joshua Rose; Erzsébet Ravasz Regan; Giorgia Zadra; Cornelia Photopoulos; Stefano Cacciatore; Denise Schultz; Natalia Scaglia; Jonathan McDunn; Angelo M. De Marzo; Massimo Loda
Clinical Studies
Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer
Falguni Parikh; Dorothée Duluc; Naoko Imai; Amelia Clark; Krzys Misiukiewicz; Marcello Bonomi; Vishal Gupta; Alexis Patsias; Michael Parides; Elizabeth G. Demicco; David Y. Zhang; Seunghee Kim-Schulze; Johnny Kao; Sacha Gnjatic; Sangkon Oh; Marshall R. Posner; Andrew G. Sikora
Integrated Systems and Technologies
Microenvironment and Immunology
Natural Killer Cells Are Essential for the Ability of BRAF Inhibitors to Control BRAFV600E-Mutant Metastatic Melanoma
Lucas Ferrari de Andrade; Shin F. Ngiow; Kimberley Stannard; Sylvie Rusakiewicz; Murugan Kalimutho; Kum Kum Khanna; Siok-Keen Tey; Kazuyoshi Takeda; Laurence Zitvogel; Ludovic Martinet; Mark J. Smyth
Molecular and Cellular Pathobiology
H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Pei-Chun Wu; Jeng-Wei Lu; Jer-Yen Yang; I-Hsuan Lin; Da-Liang Ou; Yu-Hsiang Lin; Kuan-Hsien Chou; Wen-Feng Huang; Wan-Ping Wang; Yih-Leh Huang; Chiun Hsu; Liang-In Lin; Yueh-Min Lin; C.-K. James Shen; Tsai-Yu Tzeng
Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Yann S. Gallot; Anne-Cécile Durieux; Josiane Castells; Marine M. Desgeorges; Barbara Vernus; Léa Plantureux; Didier Rémond; Vanessa E. Jahnke; Etienne Lefai; Dominique Dardevet; Georges Nemoz; Laurent Schaeffer; Anne Bonnieu; Damien G. Freyssenet
Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes
Miodrag Gužvić; Bernhard Braun; Roman Ganzer; Maximilian Burger; Michael Nerlich; Sebastian Winkler; Melanie Werner-Klein; Zbigniew T. Czyż; Bernhard Polzer; Christoph A. Klein
Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Jessica Bockhorn; Aleix Prat; Ya-Fang Chang; Xia Liu; Simo Huang; Meng Shang; Chika Nwachukwu; Maria J. Gomez-Vega; J. Chuck Harrell; Olufunmilayo I. Olopade; Charles M. Perou; Huiping Liu
Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma
Yoshiaki Chinen; Junya Kuroda; Yuji Shimura; Hisao Nagoshi; Miki Kiyota; Mio Yamamoto-Sugitani; Shinsuke Mizutani; Natsumi Sakamoto; Masaki Ri; Eri Kawata; Tsutomu Kobayashi; Yosuke Matsumoto; Shigeo Horiike; Shinsuke Iida; Masafumi Taniwaki
Prevention and Epidemiology
Plasma Choline Metabolites and Colorectal Cancer Risk in the Women's Health Initiative Observational Study
Sajin Bae; Cornelia M. Ulrich; Marian L. Neuhouser; Olga Malysheva; Lynn B. Bailey; Liren Xiao; Elissa C. Brown; Kara L. Cushing-Haugen; Yingye Zheng; Ting-Yuan David Cheng; Joshua W. Miller; Ralph Green; Dorothy S. Lane; Shirley A.A. Beresford; Marie A. Caudill
Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology
Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b
Shine-Gwo Shiah; Jenn-Ren Hsiao; Wei-Min Chang; Ya-Wen Chen; Ying-Tai Jin; Tung-Yiu Wong; Jehn-Shyun Huang; Sen-Tien Tsai; Yuan-Ming Hsu; Sung-Tau Chou; Yi-Chen Yen; Shih Sheng Jiang; Yi-Shing Shieh; I-Shou Chang; Michael Hsiao; Jang-Yang Chang
Letter to the Editor
Acknowledgment to Reviewers
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