The image shows a high resolution X-ray of a mouse hip and tumor-bearing mouse femur that was treated with anti-nerve growth antibody. Radiographs of the femur demonstrated that at day 28 postinjection of sarcoma cancer cells into the femur, early and sustained sequestration of nerve growth factor not only reduced bone cancer pain but attenuated sarcoma-induced bone destruction and delayed time to fracture. For details, see article by McCaffrey and colleagues on page 7014.