The AXL receptor tyrosine kinase has been implicated as a cellular signaling protein that is specifically upregulated in the context of the epithelial-to-mesenchymal transformation seen in some epithelial cancers and the emergence of acquired drug resistance. Among the tumor types in which a mesenchymal, largely drug-refractory phenotype appears to be prevalent is triple-negative breast cancer (TNBC). This immunohistological image illustrates the expression of AXL in a TNBC tumor specimen, revealing punctate cytoplasmic staining of AXL in tumor cells as well as focal vascular staining. For details, see article by Wilson and colleagues on page 5878.