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Volume 74, Issue 17
1 September 2014
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    Cover Image

    issue cover
    Confocal microscopy analysis for osteopontin performed on myeloid-derived suppressor cells (MDSC) shows osteopontin (red) localized under the cellular membrane but not colocalized with the ER marker concanavalin A (green) in MDSC. This picture is suggestive of the existence of an intracellular form, rather then a secreted form of osteopontin, in MDSC. For details, see article by S. Sangaletti and colleagues on page 4706.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Review

Author Choice
ACVR1 Mutations in DIPG: Lessons Learned from FOP
Kathryn R. Taylor; Maria Vinci; Alex N. Bullock; Chris Jones
View articletitled, <em>ACVR1</em> Mutations in DIPG: Lessons Learned from FOP
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Physics in Cancer Research

Introduction to Physics in Cancer Research
Herbert Levine
View articletitled, Introduction to Physics in Cancer Research
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Toward Decoding the Principles of Cancer Metastasis Circuits
Mingyang Lu; Mohit Kumar Jolly; Jose' Onuchic; Eshel Ben-Jacob
View articletitled, Toward Decoding the Principles of Cancer Metastasis Circuits
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Modeling Contact Guidance and Invasion by Cancer Cells
Leonard M. Sander
View articletitled, Modeling Contact Guidance and Invasion by Cancer Cells
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Author Choice
Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Matthew G. Rubashkin; Luke Cassereau; Russell Bainer; Christopher C. DuFort; Yoshihiro Yui; Guanqing Ou; Matthew J. Paszek; Michael W. Davidson; Yunn-Yi Chen; Valerie M. Weaver
View articletitled, Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate
Supplementary data
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Using High-Throughput Transcriptomic Data for Prognosis: A Critical Overview and Perspectives
Eytan Domany
View articletitled, Using High-Throughput Transcriptomic Data for Prognosis: A Critical Overview and Perspectives
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Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma
Jayashree Kalpathy-Cramer; Elizabeth R. Gerstner; Kyrre E. Emblem; Ovidiu C. Andronesi; Bruce Rosen
View articletitled, Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma
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Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging
Nathan S. White; Carrie R. McDonald; Niky Farid; Josh Kuperman; David Karow; Natalie M. Schenker-Ahmed; Hauke Bartsch; Rebecca Rakow-Penner; Dominic Holland; Ahmed Shabaik; Atle Bjørnerud; Tuva Hope; Jona Hattangadi-Gluth; Michael Liss; J. Kellogg Parsons; Clark C. Chen; Steve Raman; Daniel Margolis; Robert E. Reiter; Leonard Marks; Santosh Kesari; Arno J. Mundt; Christopher J. Kane; Bob S. Carter; William G. Bradley; Anders M. Dale
View articletitled, Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging
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Therapies with Diverse Mechanisms of Action Kill Cells by a Similar Exponential Process in Advanced Cancers
Krastan B. Blagoev; Julia Wilkerson; Wilfred D. Stein; James Yang; Susan E. Bates; Tito Fojo
View articletitled, Therapies with Diverse Mechanisms of Action Kill Cells by a Similar Exponential Process in Advanced Cancers
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Resistance to Chemotherapy: Patient Variability and Cellular Heterogeneity
David A. Kessler; Robert H. Austin; Herbert Levine
View articletitled, Resistance to Chemotherapy: Patient Variability and Cellular Heterogeneity
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Meeting Report

Mouse Models of Human Cancer
Barbara C. Böck; Ulrike Stein; Clemens A. Schmitt; Hellmut G. Augustin
View articletitled, Mouse Models of Human Cancer
Supplementary data
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Priority Report

Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Jeremy H. Tchaicha; Esra A. Akbay; Abigail Altabef; Oliver R. Mikse; Eiki Kikuchi; Kevin Rhee; Rachel G. Liao; Roderick T. Bronson; Lynette M. Sholl; Matthew Meyerson; Peter S. Hammerman; Kwok-Kin Wong
View articletitled, Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC
Supplementary data
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Integrated Systems and Technologies

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer
Rakesh Patel; Ashraf Khan; Robert Quinlan; Anna N. Yaroslavsky
View articletitled, Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer
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A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets
Ayumu Taguchi; Allen D. Taylor; Jaime Rodriguez; Müge Çeliktaş; Hui Liu; Xiaotu Ma; Qing Zhang; Chee-Hong Wong; Alice Chin; Luc Girard; Carmen Behrens; Wan L. Lam; Stephen Lam; John D. Minna; Ignacio I. Wistuba; Adi F. Gazdar; Samir M. Hanash
View articletitled, A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets
Supplementary data
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Microenvironment and Immunology

Osteopontin Shapes Immunosuppression in the Metastatic Niche
Sabina Sangaletti; Claudio Tripodo; Sara Sandri; Ilaria Torselli; Caterina Vitali; Chiara Ratti; Laura Botti; Alessia Burocchi; Rossana Porcasi; Andrea Tomirotti; Mario P. Colombo; Claudia Chiodoni
View articletitled, Osteopontin Shapes Immunosuppression in the Metastatic Niche
Supplementary data
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IL-1β-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis
Lin Wang; Ling-Fei Zhang; Jing Wu; Shu-Jun Xu; Yang-Yang Xu; Dangsheng Li; Jia-Tao Lou; Mo-Fang Liu
View articletitled, IL-1β-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis
Supplementary data
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Molecular and Cellular Pathobiology

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
Teresa A. Colvin; Vladimir L. Gabai; Jianlin Gong; Stuart K. Calderwood; Hu Li; Suryaram Gummuluru; Olga N. Matchuk; Svetlana G. Smirnova; Nina V. Orlova; Irina A. Zamulaeva; Mikel Garcia-Marcos; Xiaokai Li; Z.T. Young; Jennifer N. Rauch; Jason E. Gestwicki; Shinichi Takayama; Michael Y. Sherman
View articletitled, Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks
Supplementary data
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NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis
Kelly L. Weaver; Marie-Clotilde Alves-Guerra; Ke Jin; Zhiqiang Wang; Xiaoqing Han; Prathibha Ranganathan; Xiaoxia Zhu; Thiago DaSilva; Wei Liu; Francesca Ratti; Renee M. Demarest; Cristos Tzimas; Meghan Rice; Rodrigo Vasquez-Del Carpio; Nadia Dahmane; David J. Robbins; Anthony J. Capobianco
View articletitled, NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis
Supplementary data
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Therapeutics, Targets, and Chemical Biology

Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
Yun-Han Lee; Daekwan Seo; Kyung-Ju Choi; Jesper B. Andersen; Min-Ah Won; Mitsuteru Kitade; Luis E. Gómez-Quiroz; Adam D. Judge; Jens U. Marquardt; Chiara Raggi; Elizabeth A. Conner; Ian MacLachlan; Valentina M. Factor; Snorri S. Thorgeirsson
View articletitled, Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
Supplementary data
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Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Jennifer L. Yori; Kristen L. Lozada; Darcie D. Seachrist; Jonathan D. Mosley; Fadi W. Abdul-Karim; Christine N. Booth; Chris A. Flask; Ruth A. Keri
View articletitled, Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Supplementary data
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Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
Aleksandra Pandyra; Peter J. Mullen; Manpreet Kalkat; Rosemary Yu; Janice T. Pong; Zhihua Li; Suzanne Trudel; Karl S. Lang; Mark D. Minden; Aaron D. Schimmer; Linda Z. Penn
View articletitled, Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
Supplementary data
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AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis
Chih-Chien Chou; Kuen-Haur Lee; I-Lu Lai; Dasheng Wang; Xiaokui Mo; Samuel K. Kulp; Charles L. Shapiro; Ching-Shih Chen
View articletitled, AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis
Supplementary data
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Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Christina A. von Roemeling; Derek C. Radisky; Laura A. Marlow; Simon J. Cooper; Stefan K. Grebe; Panagiotis Z. Anastasiadis; Han W. Tun; John A. Copland
View articletitled, Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Supplementary data
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Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Bin Li; Dennis Liang Fei; Colin A. Flaveny; Nadia Dahmane; Valérie Baubet; Zhiqiang Wang; Feng Bai; Xin-Hai Pei; Jezabel Rodriguez-Blanco; Brian Hang; Darren Orton; Lu Han; Baolin Wang; Anthony J. Capobianco; Ethan Lee; David J. Robbins
View articletitled, Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Supplementary data
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Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
Yi-Hsin Hsu; Jun Yao; Li-Chuan Chan; Ting-Jung Wu; Jennifer L. Hsu; Yueh-Fu Fang; Yongkun Wei; Yun Wu; Wen-Chien Huang; Chien-Liang Liu; Yuan-Ching Chang; Ming-Yang Wang; Chia-Wei Li; Jia Shen; Mei-Kuang Chen; Aysegul A. Sahin; Anil Sood; Gordon B. Mills; Dihua Yu; Gabriel N. Hortobagyi; Mien-Chie Hung
View articletitled, Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
Supplementary data
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Author Choice
Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance
Shigeo Ohba; Joydeep Mukherjee; Wendy L. See; Russell O. Pieper
View articletitled, Mutant IDH1-Driven Cellular Transformation Increases RAD51-Mediated Homologous Recombination and Temozolomide Resistance
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The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Ian R. Watson; Liren Li; Peter K. Cabeceiras; Mozhdeh Mahdavi; Tony Gutschner; Giannicola Genovese; Guocan Wang; Zhuangna Fang; James M. Tepper; Katherine Stemke-Hale; Kenneth Y. Tsai; Michael A. Davies; Gordon B. Mills; Lynda Chin
View articletitled, The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Supplementary data
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Tumor and Stem Cell Biology

Author Choice
Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
David Endesfelder; Rebecca A. Burrell; Nnennaya Kanu; Nicholas McGranahan; Mike Howell; Peter J. Parker; Julian Downward; Charles Swanton; Maik Kschischo
View articletitled, Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER<sup>+</sup> Breast Cancer
Supplementary data
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Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Kin-Hoe Chow; Dong-Mi Shin; Molly H. Jenkins; Emily E. Miller; David J. Shih; Seungbum Choi; Benjamin E. Low; Vivek Philip; Brad Rybinski; Roderick T. Bronson; Michael D. Taylor; Kyuson Yun
View articletitled, Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Supplementary data
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TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior
Lingbao Ai; Wan-Ju Kim; Merve Alpay; Ming Tang; Carolina E. Pardo; Shigetsugu Hatakeyama; W. Stratford May; Michael P. Kladde; Coy D. Heldermon; Erin M. Siegel; Kevin D. Brown
View articletitled, TRIM29 Suppresses TWIST1 and Invasive Breast Cancer Behavior
Supplementary data
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TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression
Tetsuo Mashima; Taeko Soma-Nagae; Toshiro Migita; Ryoko Kinoshita; Atsushi Iwamoto; Takeshi Yuasa; Junji Yonese; Yuichi Ishikawa; Hiroyuki Seimiya
View articletitled, TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression
Supplementary data
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IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
Morteza Esmaeili; Bob C. Hamans; Anna C. Navis; Remco van Horssen; Tone F. Bathen; Ingrid S. Gribbestad; William P. Leenders; Arend Heerschap
View articletitled, IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
Supplementary data
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IL15RA Drives Antagonistic Mechanisms of Cancer Development and Immune Control in Lymphocyte-Enriched Triple-Negative Breast Cancers
Pierfrancesco Marra; Sumi Mathew; Anita Grigoriadis; Yin Wu; Fernanda Kyle-Cezar; Johnathan Watkins; Mamunur Rashid; Emanuele De Rinaldis; Sonya Hessey; Patrycja Gazinska; Adrian Hayday; Andrew Tutt
View articletitled, IL15RA Drives Antagonistic Mechanisms of Cancer Development and Immune Control in Lymphocyte-Enriched Triple-Negative Breast Cancers
Supplementary data
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Epigenetic Targeting of Ovarian Cancer Stem Cells
Yinu Wang; Horacio Cardenas; Fang Fang; Salvatore Condello; Pietro Taverna; Matthew Segar; Yunlong Liu; Kenneth P. Nephew; Daniela Matei
View articletitled, Epigenetic Targeting of Ovarian Cancer Stem Cells
Supplementary data
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Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Andrew D. Wong; Peter C. Searson
View articletitled, Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Supplementary data
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Letters to the Editor

A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1—Letter
Kenneth W. Thompson; Stefanie B. Marquez; David Reisman
View articletitled, A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1—Letter
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Proposal for a Synthetic Lethality Therapy Using the Paralog Dependence of Cancer Cells—Response
Takahiro Oike; Hideaki Ogiwara; Takashi Nakano; Takashi Kohno
View articletitled, Proposal for a Synthetic Lethality Therapy Using the Paralog Dependence of Cancer Cells—Response
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Corrections

Correction: The TGFβ–miR200–Mig6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
View articletitled, Correction: The TGFβ–miR200–Mig6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
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Correction: Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer
View articletitled, Correction: Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer
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