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Volume 74, Issue 16
15 August 2014
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    Expression of the multidrug resistance protein ABCG2 confers chemoresistance to CSC where it serves as a potential biomarker and therapeutic target. Afatinib, a small molecule inhibitor of the tyrosine kinases EGFR, HER2, and HER4, can enhance the antitumor effect of the DNA damaging drug topotecan in vitro and in vivo. Immunofluorescence microscopic analysis showed that afatinib significantly decreased the cell surface expression of ABCG2 in a concentration-dependent manner. For details, see article by X.-K. Wang and colleagues on page 4431.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Immunogenetic Studies of Chronic Lymphocytic Leukemia: Revelations and Speculations about Ontogeny and Clinical Evolution
Anna Vardi; Andreas Agathangelidis; Lesley-Ann Sutton; Paolo Ghia; Richard Rosenquist; Kostas Stamatopoulos
View articletitled, Immunogenetic Studies of Chronic Lymphocytic Leukemia: Revelations and Speculations about Ontogeny and Clinical Evolution
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Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation
S. Viaud; R. Daillère; I.G. Boneca; P. Lepage; M.J. Pittet; F. Ghiringhelli; G. Trinchieri; R. Goldszmid; L. Zitvogel
View articletitled, Harnessing the Intestinal Microbiome for Optimal Therapeutic Immunomodulation
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Priority Report

MYC Synergizes with Activated BRAFV600E in Mouse Lung Tumor Development by Suppressing Senescence
Vedrana Tabor; Matteo Bocci; Nyosha Alikhani; Raoul Kuiper; Lars-Gunnar Larsson
View articletitled, MYC Synergizes with Activated BRAF<sup>V600E</sup> in Mouse Lung Tumor Development by Suppressing Senescence
Supplementary data
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Clinical Studies

Pentraxin 3: A Novel Biomarker for Predicting Progression from Prostatic Inflammation to Prostate Cancer
Giovanni Stallone; Luigi Cormio; Giuseppe Stefano Netti; Barbara Infante; Oscar Selvaggio; Giuseppe Di Fino; Elena Ranieri; Francesca Bruno; Clelia Prattichizzo; Francesca Sanguedolce; Simona Tortorella; Pantaleo Bufo; Giuseppe Grandaliano; Giuseppe Carrieri
View articletitled, Pentraxin 3: A Novel Biomarker for Predicting Progression from Prostatic Inflammation to Prostate Cancer
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Integrated Systems and Technologies

Capillary-Wall Collagen as a Biophysical Marker of Nanotherapeutic Permeability into the Tumor Microenvironment
Kenji Yokoi; Milos Kojic; Miljan Milosevic; Tomonori Tanei; Mauro Ferrari; Arturas Ziemys
View articletitled, Capillary-Wall Collagen as a Biophysical Marker of Nanotherapeutic Permeability into the Tumor Microenvironment
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Hyperpolarized [1-13C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma
Myriam M. Chaumeil; Peder E.Z. Larson; Sarah M. Woods; Larry Cai; Pia Eriksson; Aaron E. Robinson; Janine M. Lupo; Daniel B. Vigneron; Sarah J. Nelson; Russell O. Pieper; Joanna J. Phillips; Sabrina M. Ronen
View articletitled, Hyperpolarized [1-<sup>13</sup>C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma
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Microenvironment and Immunology

Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Eva Pastille; Katrin Bardini; Diana Fleissner; Alexandra Adamczyk; Annika Frede; Munisch Wadwa; Dorthe von Smolinski; Stefan Kasper; Tim Sparwasser; Achim D. Gruber; Martin Schuler; Shimon Sakaguchi; Axel Roers; Werner Müller; Wiebke Hansen; Jan Buer; Astrid M. Westendorf
View articletitled, Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer
Supplementary data
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Molecular and Cellular Pathobiology

Cancer Affects microRNA Expression, Release, and Function in Cardiac and Skeletal Muscle
Daohong Chen; Chirayu P. Goswami; Riesa M. Burnett; Manjushree Anjanappa; Poornima Bhat-Nakshatri; William Muller; Harikrishna Nakshatri
View articletitled, Cancer Affects microRNA Expression, Release, and Function in Cardiac and Skeletal Muscle
Supplementary data
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Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Ismail Hassan Ismail; Riley Davidson; Jean-Philippe Gagné; Zhi Zhong Xu; Guy G. Poirier; Michael J. Hendzel
View articletitled, Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair
Supplementary data
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PME-1 Modulates Protein Phosphatase 2A Activity to Promote the Malignant Phenotype of Endometrial Cancer Cells
Ewa Wandzioch; Michelle Pusey; Amy Werda; Sophie Bail; Aishwarya Bhaskar; Mariya Nestor; Jing-Jing Yang; Lyndi M. Rice
View articletitled, PME-1 Modulates Protein Phosphatase 2A Activity to Promote the Malignant Phenotype of Endometrial Cancer Cells
Supplementary data
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Author Choice
AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
JuanJuan Yin; Yen-Nien Liu; Heather Tillman; Ben Barrett; Stephen Hewitt; Kris Ylaya; Lei Fang; Ross Lake; Eva Corey; Colm Morrissey; Robert Vessella; Kathleen Kelly
View articletitled, AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Supplementary data
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B-cell Expansion and Lymphomagenesis Induced by Chronic CD40 Signaling Is Strictly Dependent on CD19
Caroline Hojer; Samantha Frankenberger; Lothar J. Strobl; Samantha Feicht; Kristina Djermanovic; Franziska Jagdhuber; Cornelia Hömig-Hölzel; Uta Ferch; Jürgen Ruland; Klaus Rajewsky; Ursula Zimber-Strobl
View articletitled, B-cell Expansion and Lymphomagenesis Induced by Chronic CD40 Signaling Is Strictly Dependent on CD19
Supplementary data
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IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Katherine T. Venmar; Kathy J. Carter; Daniel G. Hwang; E. Ashley Dozier; Barbara Fingleton
View articletitled, IL4 Receptor ILR4α Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
Supplementary data
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miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Chang Gong; Yan Nie; Shaohua Qu; Jian-You Liao; Xiuying Cui; Herui Yao; Yunjie Zeng; Fengxi Su; Erwei Song; Qiang Liu
View articletitled, <em>miR-21</em> Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Supplementary data
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Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells
Jiangzhi Chen; Hong Xu; Xiuqun Zou; Jiamin Wang; Yi Zhu; Hao Chen; Baiyong Shen; Xiaxing Deng; Aiwu Zhou; Y. Eugene Chin; Frank J. Rauscher, III; Chenghong Peng; Zhaoyuan Hou
View articletitled, Snail Recruits Ring1B to Mediate Transcriptional Repression and Cell Migration in Pancreatic Cancer Cells
Supplementary data
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AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling
Jyoti Srivastava; Chadia L. Robertson; Devaraja Rajasekaran; Rachel Gredler; Ayesha Siddiq; Luni Emdad; Nitai D. Mukhopadhyay; Shobha Ghosh; Phillip B. Hylemon; Gregorio Gil; Khalid Shah; Deepak Bhere; Mark A. Subler; Jolene J. Windle; Paul B. Fisher; Devanand Sarkar
View articletitled, AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling
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In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents
Colin J. Henderson; Aileen W. McLaren; C. Roland Wolf
View articletitled, <em>In Vivo</em> Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents
Supplementary data
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Author Choice
Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Jinfei Xu; Yuwaraj Kadariya; Mitchell Cheung; Jianming Pei; Jacqueline Talarchek; Eleonora Sementino; Yinfei Tan; Craig W. Menges; Kathy Q. Cai; Samuel Litwin; Hongzhuang Peng; Jayashree Karar; Frank J. Rauscher; Joseph R. Testa
View articletitled, Germline Mutation of <em>Bap1</em> Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Supplementary data
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Prevention and Epidemiology

Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Stacey Meeker; Audrey Seamons; Jisun Paik; Piper M. Treuting; Thea Brabb; William M. Grady; Lillian Maggio-Price
View articletitled, Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Supplementary data
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Therapeutics, Targets, and Chemical Biology

Author Choice
Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Hengyou Weng; Huilin Huang; Bowen Dong; Panpan Zhao; Hui Zhou; Lianghu Qu
View articletitled, Inhibition of miR-17 and miR-20a by Oridonin Triggers Apoptosis and Reverses Chemoresistance by Derepressing BIM-S
Supplementary data
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ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Dalin He; Lei Li; Guodong Zhu; Liang Liang; Zhenfeng Guan; Luke Chang; Yuan Chen; Shuyuan Yeh; Chawnshang Chang
View articletitled, ASC-J9 Suppresses Renal Cell Carcinoma Progression by Targeting an Androgen Receptor–Dependent HIF2α/VEGF Signaling Pathway
Supplementary data
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Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Xiao-kun Wang; Jie-hua He; Jing-hong Xu; Sheng Ye; Fang Wang; Hui Zhang; Zhen-cong Huang; Kenneth Kin Wah To; Li-wu Fu
View articletitled, Afatinib Enhances the Efficacy of Conventional Chemotherapeutic Agents by Eradicating Cancer Stem–like Cells
Supplementary data
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NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin–Aromatase Interactions
Laura W. Bowers; Ilane X.F. Maximo; Andrew J. Brenner; Muralidhar Beeram; Stephen D. Hursting; Ramona S. Price; Rajeshwar R. Tekmal; Christopher A. Jolly; Linda A. deGraffenried
View articletitled, NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin–Aromatase Interactions
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Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition
Naoya Mimura; Teru Hideshima; Toshiyasu Shimomura; Rikio Suzuki; Hiroto Ohguchi; Ola Rizq; Shohei Kikuchi; Yasuhiro Yoshida; Francesca Cottini; Jana Jakubikova; Diana Cirstea; Gullu Gorgun; Jiro Minami; Yu-Tzu Tai; Paul G. Richardson; Teruhiro Utsugi; Atsushi Iwama; Kenneth C. Anderson
View articletitled, Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition
Supplementary data
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Author Choice
Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
Mary E. Vail; Carmel Murone; April Tan; Linda Hii; Degu Abebe; Peter W. Janes; Fook-Thean Lee; Mark Baer; Varghese Palath; Christopher Bebbington; Geoffrey Yarranton; Carmen Llerena; Slavisa Garic; David Abramson; Glenn Cartwright; Andrew M. Scott; Martin Lackmann
View articletitled, Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment
Supplementary data
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Tumor and Stem Cell Biology

Crosstalk between Glioma-Initiating Cells and Endothelial Cells Drives Tumor Progression
Hye-Min Jeon; Sung-Hak Kim; Xun Jin; Jong Bae Park; Se Hoon Kim; Kaushal Joshi; Ichiro Nakano; Hyunggee Kim
View articletitled, Crosstalk between Glioma-Initiating Cells and Endothelial Cells Drives Tumor Progression
Supplementary data
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YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Yulei Zhao; Prem Khanal; Paul Savage; Yi-Min She; Terry D. Cyr; Xiaolong Yang
View articletitled, YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway
Supplementary data
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Heparanase Cooperates with Ras to Drive Breast and Skin Tumorigenesis
Ilanit Boyango; Uri Barash; Inna Naroditsky; Jin-Ping Li; Edward Hammond; Neta Ilan; Israel Vlodavsky
View articletitled, Heparanase Cooperates with <em>Ras</em> to Drive Breast and Skin Tumorigenesis
Supplementary data
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β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Sharada Mokkapati; Katharina Niopek; Le Huang; Kegan J. Cunniff; E. Cristy Ruteshouser; Mark deCaestecker; Milton J. Finegold; Vicki Huff
View articletitled, β-Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma
Supplementary data
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EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Hong-Jun Kang; Jun Hong Park; WeiPing Chen; Soo Im Kang; Krzysztof Moroz; Marc Ladanyi; Sean Bong Lee
View articletitled, EWS–WT1 Oncoprotein Activates Neuronal Reprogramming Factor ASCL1 and Promotes Neural Differentiation
Supplementary data
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Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma
Gang Chen; Jun Kong; Carol Tucker-Burden; Monika Anand; Yuan Rong; Fahmia Rahman; Carlos S. Moreno; Erwin G. Van Meir; Constantinos G. Hadjipanayis; Daniel J. Brat
View articletitled, Human <em>Brat</em> Ortholog <em>TRIM3</em> Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma
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Author Choice
Hypoxia Promotes Nuclear Translocation and Transcriptional Function in the Oncogenic Tyrosine Kinase RON
Hong-Yi Chang; Hsiao-Sheng Liu; Ming-Derg Lai; Yuh-Shyan Tsai; Tzong-Shin Tzai; Hong-Ling Cheng; Nan-Haw Chow
View articletitled, Hypoxia Promotes Nuclear Translocation and Transcriptional Function in the Oncogenic Tyrosine Kinase RON
Supplementary data
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  • Print ISSN 0008-5472

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