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15 July 2014
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Cover Image
Cover Image
Cancer cells overexpressing uncoupling protein 2 (UCP2), a mitochondrial carrier, shift their metabolism from glycolysis toward oxidative phosphorylation and become less proliferative and poorly tumorigenic. Indeed, immunodeficient mice implanted subcutaneously with melanoma B16F10 cells (top) developed bigger tumors than UCP2 overexpressing B16F10 cells (bottom). Our results further demonstrate that, by controlling mitochondrial substrate routing, UCP2 drives a feed-forward loop from mitochondria to AMPK and HIF, with direct impact on the transformed phenotype of cancer cells. For details, see article by Esteves and colleagues on page 3971.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Priority Report
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Netrin-1 Promotes Medulloblastoma Cell Invasiveness and Angiogenesis, and Demonstrates Elevated Expression in Tumor Tissue and Urine of Patients with Pediatric Medulloblastoma
Tomoshige Akino; Xuezhe Han; Hironao Nakayama; Brendan McNeish; David Zurakowski; Akiko Mammoto; Michael Klagsbrun; Edward Smith
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Author Choice
Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Sweta Rani; Claire Corcoran; Liam Shiels; Serena Germano; Susan Breslin; Stephen Madden; Martina S. McDermott; Brigid C. Browne; Norma O'Donovan; John Crown; Martina Gogarty; Annette T. Byrne; Lorraine O'Driscoll
Tumor and Stem Cell Biology
NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
Filippos Kottakis; Parthena Foltopoulou; Ioannis Sanidas; Patricia Keller; Ania Wronski; Benjamin T. Dake; Scott A. Ezell; Zhu Shen; Stephen P. Naber; Philip W. Hinds; Elizabeth McNiel; Charlotte Kuperwasser; Philip N. Tsichlis
Author Choice
Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis
Pauline Esteves; Claire Pecqueur; Céline Ransy; Catherine Esnous; Véronique Lenoir; Frédéric Bouillaud; Anne-Laure Bulteau; Anne Lombès; Carina Prip-Buus; Daniel Ricquier; Marie-Clotilde Alves-Guerra
Correction
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