Skip Nav Destination
Issues
1 July 2014
-
Cover Image
Cover Image
Pancreatic cancer is the most aggressive tumor, showing almost identical incidence and mortality values. Emerging data have highlighted the paramount contribution of tumor epithelium-stroma cross-talk in tumor progression. Galectin-1, a glycan-binding protein, is highly expressed in the stroma of pancreatic ductal tumors from Ela-myc mice, suggesting a role in cancer progression. Interestingly, genetic depletion of Galectin-1 in this model decreases tumor proliferation, angiogenesis, stroma formation and acinar to ductal metaplasia, and restores the immune surveillance, leading to a significant increase in animal lifespan. These results show that Galectin-1 favors tumor progression by modulation of the tumor microenvironment, suggesting that this lectin is a potential target for therapy. For details, see article by Martínez-Bosch and colleagues on page 3512.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia?
Anne Marie Lennon; Christopher L. Wolfgang; Marcia Irene Canto; Alison P. Klein; Joseph M. Herman; Michael Goggins; Elliot K. Fishman; Ihab Kamel; Matthew J. Weiss; Luis A. Diaz; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Ralph H. Hruban
Perspective
Meeting Report
Clinical Studies
Microenvironment and Immunology
Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Francesca Bruzzese; Christina Hägglöf; Alessandra Leone; Elin Sjöberg; Maria Serena Roca; Sara Kiflemariam; Tobias Sjöblom; Peter Hammarsten; Lars Egevad; Anders Bergh; Arne Östman; Alfredo Budillon; Martin Augsten
Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Eva Schlecker; Nathalie Fiegler; Annette Arnold; Peter Altevogt; Stefan Rose-John; Gerhard Moldenhauer; Antje Sucker; Annette Paschen; Elke Pogge von Strandmann; Sonja Textor; Adelheid Cerwenka
Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1–PD-L1 Axis
Zhi-Chun Ding; Xiaoyun Lu; Miao Yu; Henrique Lemos; Lei Huang; Phillip Chandler; Kebin Liu; Matthew Walters; Antoni Krasinski; Matthias Mack; Bruce R. Blazar; Andrew L. Mellor; David H. Munn; Gang Zhou
Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche
Surya Kumari Vadrevu; Navin K. Chintala; Sharad K. Sharma; Priya Sharma; Clayton Cleveland; Linley Riediger; Sasikanth Manne; David P. Fairlie; Wojciech Gorczyca; Othon Almanza; Magdalena Karbowniczek; Maciej M. Markiewski
Autologous T-cell Therapy for Cytomegalovirus as a Consolidative Treatment for Recurrent Glioblastoma
Andrea Schuessler; Corey Smith; Leone Beagley; Glen M. Boyle; Sweera Rehan; Katherine Matthews; Linda Jones; Tania Crough; Vijayendra Dasari; Kerenaftali Klein; Amy Smalley; Hamish Alexander; David G. Walker; Rajiv Khanna
Molecular and Cellular Pathobiology
Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Neus Martínez-Bosch; Maite G. Fernández-Barrena; Mireia Moreno; Elena Ortiz-Zapater; Jessica Munné-Collado; Mar Iglesias; Sabine André; Hans-Joachim Gabius; Rosa F. Hwang; Françoise Poirier; Carolina Navas; Carmen Guerra; Martin E. Fernández-Zapico; Pilar Navarro
Prevention and Epidemiology
No Causal Association Identified for Human Papillomavirus Infections in Lung Cancer
Devasena Anantharaman; Tarik Gheit; Tim Waterboer; Gordana Halec; Christine Carreira; Behnoush Abedi-Ardekani; Sandrine McKay-Chopin; David Zaridze; Anush Mukeria; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Dana Mates; Vladimir Janout; Lenka Foretova; Vladimir Bencko; Peter Rudnai; Eleonora Fabianova; Anne Tjønneland; Ruth C. Travis; Heiner Boeing; J. Ramón Quirós; Mikael Johansson; Vittorio Krogh; H. Bas Bueno-de-Mesquita; Anastasia Kotanidou; Françoise Clavel-Chapelon; Elisabete Weiderpass; Mattias Johansson; Michael Pawlita; Ghislaine Scelo; Massimo Tommasino; Paul Brennan
Therapeutics, Targets, and Chemical Biology
Author Choice
Re-engineering Vesicular Stomatitis Virus to Abrogate Neurotoxicity, Circumvent Humoral Immunity, and Enhance Oncolytic Potency
Alexander Muik; Lawton J. Stubbert; Roza Z. Jahedi; Yvonne Geiβ; Janine Kimpel; Catherine Dold; Reinhard Tober; Andreas Volk; Sabine Klein; Ursula Dietrich; Beta Yadollahi; Theresa Falls; Hrvoje Miletic; David Stojdl; John C. Bell; Dorothee von Laer
Tumor and Stem Cell Biology
Corrections
Advertisement