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15 June 2014
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B-RafV600E inhibitors are potent at halting melanoma progression in patients harboring oncogenic B-RafV600E mutation. Recent studies indicate that chemotherapies and other target treatments suppress tumor growth via a host immunity-dependent manner. Using a genetically modified mouse model of melanoma, it was found that diminished CD40L- and IFNγ-mediated signaling contributed to the formation of immunosuppressive tumor microenvironment and that treatment with a BrafV600E inhibitor, PLX4720, could reinvigorate local immune function. Indeed, maximal effectiveness of PLX4720 was dependent on restoration of CD40L- and IFNγ-mediated immune signals. This study illustrates that certain chemotherapies directed at the tumor rely on immune signaling pathways and that this has relevance for the design of combined treatments with immunotherapies. For details, see the article by Ho and colleagues on page 3205.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Qi Long; Jianpeng Xu; Adeboye O. Osunkoya; Soma Sannigrahi; Brent A. Johnson; Wei Zhou; Theresa Gillespie; Jong Y. Park; Robert K. Nam; Linda Sugar; Aleksandra Stanimirovic; Arun K. Seth; John A. Petros; Carlos S. Moreno
Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Dmitri Mouradov; Clare Sloggett; Robert N. Jorissen; Christopher G. Love; Shan Li; Antony W. Burgess; Diego Arango; Robert L. Strausberg; Daniel Buchanan; Samuel Wormald; Liam O'Connor; Jennifer L. Wilding; David Bicknell; Ian P.M. Tomlinson; Walter F. Bodmer; John M. Mariadason; Oliver M. Sieber
Prevention and Epidemiology
Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer
Ewy A. Mathé; Andrew D. Patterson; Majda Haznadar; Soumen K. Manna; Kristopher W. Krausz; Elise D. Bowman; Peter G. Shields; Jeffrey R. Idle; Philip B. Smith; Katsuhiro Anami; Dickran G. Kazandjian; Emmanuel Hatzakis; Frank J. Gonzalez; Curtis C. Harris
Therapeutics, Targets, and Chemical Biology
Notch3 Pathway Alterations in Ovarian Cancer
Wei Hu; Tao Liu; Cristina Ivan; Yunjie Sun; Jie Huang; Lingegowda S. Mangala; Takahito Miyake; Heather J. Dalton; Sunila Pradeep; Rajesh Rupaimoole; Rebecca A. Previs; Hee Dong Han; Justin Bottsford-Miller; Behrouz Zand; Yu Kang; Chad V. Pecot; Alpa M. Nick; Sherry Y. Wu; Ju-Seog Lee; Vasudha Sehgal; Prahlad Ram; Jinsong Liu; Susan L. Tucker; Gabriel Lopez-Berestein; Keith A. Baggerly; Robert L. Coleman; Anil K. Sood
Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling
Marie Schoumacher; Kristen E. Hurov; Joseph Lehár; Yan Yan-Neale; Yuji Mishina; Dmitriy Sonkin; Joshua M. Korn; Daisy Flemming; Michael D. Jones; Brandon Antonakos; Vesselina G. Cooke; Janine Steiger; Jebediah Ledell; Mark D. Stump; William R. Sellers; Nika N. Danial; Wenlin Shao
IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism
Alexandra R. Grassian; Seth J. Parker; Shawn M. Davidson; Ajit S. Divakaruni; Courtney R. Green; Xiamei Zhang; Kelly L. Slocum; Minying Pu; Fallon Lin; Chad Vickers; Carol Joud-Caldwell; Franklin Chung; Hong Yin; Erika D. Handly; Christopher Straub; Joseph D. Growney; Matthew G. Vander Heiden; Anne N. Murphy; Raymond Pagliarini; Christian M. Metallo
Tumor and Stem Cell Biology
Transient Induction of ING4 by Myc Drives Prostate Epithelial Cell Differentiation and Its Disruption Drives Prostate Tumorigenesis
Penny L. Berger; Sander B. Frank; Veronique V. Schulz; Eric A. Nollet; Mathew J. Edick; Brittany Holly; Ting-Tung A. Chang; Galen Hostetter; Suwon Kim; Cindy K. Miranti
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