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Volume 74, Issue 1

1 January 2014

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Cover Image

Cover Image

Changes in intratumoral macrophages in response to CSF-1R inhibitor, PLX3397. C57BL/6 mice with established SM1-OVA murine melanoma tumors received OT-1 ACT without the small molecule inhibitor, PLX3397. Tissue immunofluorescence microscopy was performed to detect macrophages by anti-F4/80-FITC staining (green) and nuclei stained with DAPI (blue). SM1-OVA tumors in the OT-1 ACT group were infiltrated with more intratumoral macrophages compared with other groups treated with PLX3397. For details, see article by Mok and colleagues on page 153.
Table of Contents

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Advances
Reviews
Priority Reports
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology

Cancer Research

Breaking Advances

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Reviews

β1 Integrin: Critical Path to Antiangiogenic Therapy Resistance and Beyond

Arman Jahangiri; Manish K. Aghi; W. Shawn Carbonell

Abstract

View articletitled, β1 Integrin: Critical Path to Antiangiogenic Therapy Resistance and Beyond

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Author Choice

Inflammation Amplifier, a New Paradigm in Cancer Biology

Toru Atsumi; Rajeev Singh; Lavannya Sabharwal; Hidenori Bando; Jie Meng; Yasunobu Arima; Moe Yamada; Masaya Harada; Jing-Jing Jiang; Daisuke Kamimura; Hideki Ogura; Toshio Hirano; Masaaki Murakami

Abstract

View articletitled, Inflammation Amplifier, a New Paradigm in Cancer Biology

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Priority Reports

Author Choice

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition

Hailing Cheng; Pixu Liu; Fan Zhang; Erbo Xu; Lynn Symonds; Carolynn E. Ohlson; Roderick T. Bronson; Sauveur-Michel Maira; Emmanuelle Di Tomaso; Jane Li; Andrea P. Myers; Lewis C. Cantley; Gordon B. Mills; Jean J. Zhao

Abstracts

View articletitled, A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition

Supplementary data

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Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

Damya Laoui; Eva Van Overmeire; Giusy Di Conza; Chiara Aldeni; Jiri Keirsse; Yannick Morias; Kiavash Movahedi; Isabelle Houbracken; Elio Schouppe; Yvon Elkrim; Oussama Karroum; Bénédicte Jordan; Peter Carmeliet; Conny Gysemans; Patrick De Baetselier; Massimiliano Mazzone; Jo A. Van Ginderachter

Abstracts

View articletitled, Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

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Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer

Jamin D. Steffen; Renee M. Tholey; Marie-France Langelier; Jamie L. Planck; Matthew J. Schiewer; Shruti Lal; Nikolai A. Bildzukewicz; Charles J. Yeo; Karen E. Knudsen; Jonathan R. Brody; John M. Pascal

Abstracts

View articletitled, Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer

Supplementary data

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The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development

Amudhan Venkateswaran; Konjeti R. Sekhar; Daniel S. Levic; David B. Melville; Travis A. Clark; Witold M. Rybski; Alexandra J. Walsh; Melissa C. Skala; Peter A. Crooks; Ela W. Knapik; Michael L. Freeman

Abstracts

View articletitled, The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development

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Integrated Systems and Technologies

A Macrophage-Specific Fluorescent Probe for Intraoperative Lymph Node Staging

Jung Sun Yoo; Sung-Chan Lee; Zhi Yen Jow; Pamela Yun Xiang Koh; Young-Tae Chang

Abstracts

View articletitled, A Macrophage-Specific Fluorescent Probe for Intraoperative Lymph Node Staging

Supplementary data

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A Preclinical Assay for Chemosensitivity in Multiple Myeloma

Zayar P. Khin; Maria L.C. Ribeiro; Timothy Jacobson; Lori Hazlehurst; Lia Perez; Rachid Baz; Kenneth Shain; Ariosto S. Silva

Abstracts

View articletitled, A Preclinical Assay for Chemosensitivity in Multiple Myeloma

Supplementary data

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Microenvironment and Immunology

Regulation of CD4⁺NKG2D⁺ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Ana I. Romero; Nathalie Chaput; Vichnou Poirier-Colame; Sylvie Rusakiewicz; Nicolas Jacquelot; Kariman Chaba; Erwan Mortier; Yannick Jacques; Sophie Caillat-Zucman; Caroline Flament; Anne Caignard; Meriem Messaoudene; Anne Aupérin; Philippe Vielh; Philippe Dessen; Camillo Porta; Christine Mateus; Maha Ayyoub; Danila Valmori; Alexander Eggermont; Caroline Robert; Laurence Zitvogel

Abstracts

View articletitled, Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Supplementary data

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Mature Cytotoxic CD56^bright/CD16⁺ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma

Meriem Messaoudene; Giulia Fregni; Emmanuelle Fourmentraux-Neves; Johan Chanal; Eve Maubec; Sarra Mazouz-Dorval; Benoit Couturaud; Angelique Girod; Xavier Sastre-Garau; Sebastien Albert; Charles Guédon; Lydia Deschamps; Delphine Mitilian; Isabelle Cremer; Nicolas Jacquelot; Sylvie Rusakiewicz; Laurence Zitvogel; Marie-Francoise Avril; Anne Caignard

Abstracts

View articletitled, Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma

Supplementary data

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T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing

Ko Kudo; Chihaya Imai; Paolo Lorenzini; Takahiro Kamiya; Koji Kono; Andrew M. Davidoff; Wee Joo Chng; Dario Campana

Abstracts

View articletitled, T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing

Supplementary data

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Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer

Darya Alizadeh; Malika Trad; Neale T. Hanke; Claire B. Larmonier; Nona Janikashvili; Bernard Bonnotte; Emmanuel Katsanis; Nicolas Larmonier

Abstracts

View articletitled, Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer

Supplementary data

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Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas

Dario Sangiolo; Giulia Mesiano; Loretta Gammaitoni; Valeria Leuci; Maja Todorovic; Lidia Giraudo; Cristina Cammarata; Carmine Dell'Aglio; Lorenzo D'Ambrosio; Alberto Pisacane; Ivana Sarotto; Sara Miano; Ivana Ferrero; Fabrizio Carnevale-Schianca; Ymera Pignochino; Francesco Sassi; Andrea Bertotti; Wanda Piacibello; Franca Fagioli; Massimo Aglietta; Giovanni Grignani

Abstracts

View articletitled, Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas

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Author Choice

Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30⁺ T Lymphocytes with Progression

Viviana Vallacchi; Elisabetta Vergani; Chiara Camisaschi; Paola Deho; Antonello D. Cabras; Marialuisa Sensi; Loris De Cecco; Niccolò Bassani; Federico Ambrogi; Antonino Carbone; Federica Crippa; Barbara Vergani; Paola Frati; Flavio Arienti; Roberto Patuzzo; Antonello Villa; Elia Biganzoli; Silvana Canevari; Mario Santinami; Chiara Castelli; Licia Rivoltini; Monica Rodolfo

Abstracts

View articletitled, Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression

Supplementary data

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Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

Pingyan Cheng; Vinit Kumar; Hao Liu; Je-In Youn; Mayer Fishman; Simon Sherman; Dmitry Gabrilovich

Abstracts

View articletitled, Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

Supplementary data

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Author Choice

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Stephen Mok; Richard C. Koya; Christopher Tsui; Jingying Xu; Lídia Robert; Lily Wu; Thomas G. Graeber; Brian L. West; Gideon Bollag; Antoni Ribas

Abstracts

View articletitled, Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Supplementary data

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Molecular and Cellular Pathobiology

MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer

Adam J. MacNeil; Shun-Chang Jiao; Lori A. McEachern; Yong Jun Yang; Amanda Dennis; Haiming Yu; Zhaolin Xu; Jean S. Marshall; Tong-Jun Lin

Abstracts

View articletitled, MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer

Supplementary data

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Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression

Trenis D. Palmer; Carlos H. Martínez; Catalina Vasquez; Katie E. Hebron; Celestial Jones-Paris; Shanna A. Arnold; Susanne M. Chan; Venu Chalasani; Jose A. Gomez-Lemus; Andrew K. Williams; Joseph L. Chin; Giovanna A. Giannico; Tatiana Ketova; John D. Lewis; Andries Zijlstra

Abstracts

View articletitled, Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression

Supplementary data

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HTLV-1 bZIP Factor Suppresses Apoptosis by Attenuating the Function of FoxO3a and Altering Its Localization

Azusa Tanaka-Nakanishi; Jun-ichirou Yasunaga; Ken Takai; Masao Matsuoka

Abstracts

View articletitled, HTLV-1 bZIP Factor Suppresses Apoptosis by Attenuating the Function of FoxO3a and Altering Its Localization

Supplementary data

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Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation

Sejeong Shin; Laura Wolgamott; Philippe P. Roux; Sang-Oh Yoon

Abstracts

View articletitled, Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation

Supplementary data

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Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

Maohua Xie; Yun Yen; Taofeek K. Owonikoko; Suresh S. Ramalingam; Fadlo R. Khuri; Walter J. Curran; Paul W. Doetsch; Xingming Deng

Abstracts

View articletitled, Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

Supplementary data

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Author Choice

3′-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair–Deficient Cancers

Shivendra Kishore; Salvatore Piscuoglio; Michal B. Kovac; Annette Gylling; Friedel Wenzel; Francesca Trapani; Hans Joerg Altermatt; Valentina Mele; Giancarlo Marra; Päivi Peltomäki; Luigi Terracciano; Mihaela Zavolan; Karl Heinimann

Abstracts

View articletitled, 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair–Deficient Cancers

Supplementary data

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Prevention and Epidemiology

Childhood Height and Body Mass Index Were Associated with Risk of Adult Thyroid Cancer in a Large Cohort Study

Cari M. Kitahara; Michael Gamborg; Amy Berrington de González; Thorkild I.A. Sørensen; Jennifer L. Baker

Abstracts

View articletitled, Childhood Height and Body Mass Index Were Associated with Risk of Adult Thyroid Cancer in a Large Cohort Study

Supplementary data

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6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1

Haitao Li; Feng Zhu; Hanyong Chen; Ka Wing Cheng; Tatyana Zykova; Naomi Oi; Ronald A. Lubet; Ann M. Bode; Mingfu Wang; Zigang Dong

Abstracts

View articletitled, 6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1

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Therapeutics, Targets, and Chemical Biology

MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

Jin Kyung Rho; Yun Jung Choi; Seon Ye Kim; Tae Won Kim; Eun Kyung Choi; Seon-Joo Yoon; Bu Man Park; Eunhye Park; Jong Hwan Bae; Chang-Min Choi; Jae Cheol Lee

Abstracts

View articletitled, MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

Supplementary data

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A Reevaluation of CD22 Expression in Human Lung Cancer

Laurentiu M. Pop; Stephen Barman; Chunli Shao; Jonathan C. Poe; Guglielmo M. Venturi; John M. Shelton; Iliodora V. Pop; David E. Gerber; Luc Girard; Xiao-yun Liu; Carmen Behrens; Jaime Rodriguez-Canales; Hui Liu; Ignacio I. Wistuba; James A. Richardson; John D. Minna; Thomas F. Tedder; Ellen S. Vitetta

Abstracts

View articletitled, A Reevaluation of CD22 Expression in Human Lung Cancer

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USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression

Randy S. Schrecengost; Jeffry L. Dean; Jonathan F. Goodwin; Matthew J. Schiewer; Mark W. Urban; Timothy J. Stanek; Robyn T. Sussman; Jessica L. Hicks; Ruth C. Birbe; Rossitza A. Draganova-Tacheva; Tapio Visakorpi; Angelo M. DeMarzo; Steven B. McMahon; Karen E. Knudsen

Abstracts

View articletitled, USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression

Supplementary data

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Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

Ilirjana Bajrami; Jessica R. Frankum; Asha Konde; Rowan E. Miller; Farah L. Rehman; Rachel Brough; James Campbell; David Sims; Rumana Rafiq; Sean Hooper; Lina Chen; Iwanka Kozarewa; Ioannis Assiotis; Kerry Fenwick; Rachael Natrajan; Christopher J. Lord; Alan Ashworth

Abstracts

View articletitled, Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity

Supplementary data

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SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin

Dong Hoon Shin; Yong-Joon Choi; Jong-Wan Park

Abstracts

View articletitled, SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin

Supplementary data

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Tumor and Stem Cell Biology

ERK1/2 Blockade Prevents Epithelial–Mesenchymal Transition in Lung Cancer Cells and Promotes Their Sensitivity to EGFR Inhibition

Janine M. Buonato; Matthew J. Lazzara

Abstracts

View articletitled, ERK1/2 Blockade Prevents Epithelial–Mesenchymal Transition in Lung Cancer Cells and Promotes Their Sensitivity to EGFR Inhibition

Supplementary data

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Author Choice

ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

Hemant K. Bid; Ryan D. Roberts; Maren Cam; Anthony Audino; Raushan T. Kurmasheva; Jiayuh Lin; Peter J. Houghton; Hakan Cam

Abstracts

View articletitled, ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis

Supplementary data

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Cancer Usurps Skeletal Muscle as an Energy Repository

Yi Luo; Junya Yoneda; Hitoshi Ohmori; Takamitsu Sasaki; Kazutaka Shimbo; Sachise Eto; Yumiko Kato; Hiroshi Miyano; Tsuyoshi Kobayashi; Tomonori Sasahira; Yoshitomo Chihara; Hiroki Kuniyasu

Abstracts

View articletitled, Cancer Usurps Skeletal Muscle as an Energy Repository

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Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation

Cleo Yi-Fang Lee; Yuan Lin; Scott V. Bratman; Weiguo Feng; Angera H. Kuo; Ferenc A. Scheeren; Jesse M. Engreitz; Sushama Varma; Robert B. West; Maximilian Diehn

Abstracts

View articletitled, Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation

Supplementary data

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Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer

Zlatko Smole; Claudio R. Thoma; Kathryn T. Applegate; Maria Duda; Katrin L. Gutbrodt; Gaudenz Danuser; Wilhelm Krek

Abstracts

View articletitled, Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer

Supplementary data

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14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation

Sumaiyah K. Rehman; Shau-Hsuan Li; Shannon L. Wyszomierski; Qingfei Wang; Ping Li; Ozgur Sahin; Yi Xiao; Siyuan Zhang; Yan Xiong; Jun Yang; Hai Wang; Hua Guo; Jitao D. Zhang; Daniel Medina; William J. Muller; Dihua Yu

Abstracts

View articletitled, 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation

Supplementary data

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Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation

Laura R. Bohrer; Pavlina Chuntova; Lindsey K. Bade; Thomas C. Beadnell; Ronald P. Leon; Nicholas J. Brady; Yungil Ryu; Jodi E. Goldberg; Stephen C. Schmechel; Joseph S. Koopmeiners; James B. McCarthy; Kathryn L. Schwertfeger

Abstracts

View articletitled, Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation

Supplementary data

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Author Choice

Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair

Patrick J. Halvey; Xiaojing Wang; Jing Wang; Ajaz A. Bhat; Punita Dhawan; Ming Li; Bing Zhang; Daniel C. Liebler; Robbert J.C. Slebos

Abstracts

View articletitled, Proteogenomic Analysis Reveals Unanticipated Adaptations of Colorectal Tumor Cells to Deficiencies in DNA Mismatch Repair

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cancer Research

Table of Contents

Breaking Advances

Reviews

Priority Reports

Integrated Systems and Technologies

Microenvironment and Immunology

Molecular and Cellular Pathobiology

Prevention and Epidemiology

Therapeutics, Targets, and Chemical Biology

Tumor and Stem Cell Biology

Journal Archive

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