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1 January 2014
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Changes in intratumoral macrophages in response to CSF-1R inhibitor, PLX3397. C57BL/6 mice with established SM1-OVA murine melanoma tumors received OT-1 ACT without the small molecule inhibitor, PLX3397. Tissue immunofluorescence microscopy was performed to detect macrophages by anti-F4/80-FITC staining (green) and nuclei stained with DAPI (blue). SM1-OVA tumors in the OT-1 ACT group were infiltrated with more intratumoral macrophages compared with other groups treated with PLX3397. For details, see article by Mok and colleagues on page 153.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Priority Reports
Author Choice
A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
Hailing Cheng; Pixu Liu; Fan Zhang; Erbo Xu; Lynn Symonds; Carolynn E. Ohlson; Roderick T. Bronson; Sauveur-Michel Maira; Emmanuelle Di Tomaso; Jane Li; Andrea P. Myers; Lewis C. Cantley; Gordon B. Mills; Jean J. Zhao
Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Damya Laoui; Eva Van Overmeire; Giusy Di Conza; Chiara Aldeni; Jiri Keirsse; Yannick Morias; Kiavash Movahedi; Isabelle Houbracken; Elio Schouppe; Yvon Elkrim; Oussama Karroum; Bénédicte Jordan; Peter Carmeliet; Conny Gysemans; Patrick De Baetselier; Massimiliano Mazzone; Jo A. Van Ginderachter
The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development
Amudhan Venkateswaran; Konjeti R. Sekhar; Daniel S. Levic; David B. Melville; Travis A. Clark; Witold M. Rybski; Alexandra J. Walsh; Melissa C. Skala; Peter A. Crooks; Ela W. Knapik; Michael L. Freeman
Integrated Systems and Technologies
Microenvironment and Immunology
Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Ana I. Romero; Nathalie Chaput; Vichnou Poirier-Colame; Sylvie Rusakiewicz; Nicolas Jacquelot; Kariman Chaba; Erwan Mortier; Yannick Jacques; Sophie Caillat-Zucman; Caroline Flament; Anne Caignard; Meriem Messaoudene; Anne Aupérin; Philippe Vielh; Philippe Dessen; Camillo Porta; Christine Mateus; Maha Ayyoub; Danila Valmori; Alexander Eggermont; Caroline Robert; Laurence Zitvogel
Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Meriem Messaoudene; Giulia Fregni; Emmanuelle Fourmentraux-Neves; Johan Chanal; Eve Maubec; Sarra Mazouz-Dorval; Benoit Couturaud; Angelique Girod; Xavier Sastre-Garau; Sebastien Albert; Charles Guédon; Lydia Deschamps; Delphine Mitilian; Isabelle Cremer; Nicolas Jacquelot; Sylvie Rusakiewicz; Laurence Zitvogel; Marie-Francoise Avril; Anne Caignard
Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas
Dario Sangiolo; Giulia Mesiano; Loretta Gammaitoni; Valeria Leuci; Maja Todorovic; Lidia Giraudo; Cristina Cammarata; Carmine Dell'Aglio; Lorenzo D'Ambrosio; Alberto Pisacane; Ivana Sarotto; Sara Miano; Ivana Ferrero; Fabrizio Carnevale-Schianca; Ymera Pignochino; Francesco Sassi; Andrea Bertotti; Wanda Piacibello; Franca Fagioli; Massimo Aglietta; Giovanni Grignani
Author Choice
Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Viviana Vallacchi; Elisabetta Vergani; Chiara Camisaschi; Paola Deho; Antonello D. Cabras; Marialuisa Sensi; Loris De Cecco; Niccolò Bassani; Federico Ambrogi; Antonino Carbone; Federica Crippa; Barbara Vergani; Paola Frati; Flavio Arienti; Roberto Patuzzo; Antonello Villa; Elia Biganzoli; Silvana Canevari; Mario Santinami; Chiara Castelli; Licia Rivoltini; Monica Rodolfo
Molecular and Cellular Pathobiology
Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression
Trenis D. Palmer; Carlos H. Martínez; Catalina Vasquez; Katie E. Hebron; Celestial Jones-Paris; Shanna A. Arnold; Susanne M. Chan; Venu Chalasani; Jose A. Gomez-Lemus; Andrew K. Williams; Joseph L. Chin; Giovanna A. Giannico; Tatiana Ketova; John D. Lewis; Andries Zijlstra
Author Choice
3′-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair–Deficient Cancers
Shivendra Kishore; Salvatore Piscuoglio; Michal B. Kovac; Annette Gylling; Friedel Wenzel; Francesca Trapani; Hans Joerg Altermatt; Valentina Mele; Giancarlo Marra; Päivi Peltomäki; Luigi Terracciano; Mihaela Zavolan; Karl Heinimann
Prevention and Epidemiology
Therapeutics, Targets, and Chemical Biology
A Reevaluation of CD22 Expression in Human Lung Cancer
Laurentiu M. Pop; Stephen Barman; Chunli Shao; Jonathan C. Poe; Guglielmo M. Venturi; John M. Shelton; Iliodora V. Pop; David E. Gerber; Luc Girard; Xiao-yun Liu; Carmen Behrens; Jaime Rodriguez-Canales; Hui Liu; Ignacio I. Wistuba; James A. Richardson; John D. Minna; Thomas F. Tedder; Ellen S. Vitetta
USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression
Randy S. Schrecengost; Jeffry L. Dean; Jonathan F. Goodwin; Matthew J. Schiewer; Mark W. Urban; Timothy J. Stanek; Robyn T. Sussman; Jessica L. Hicks; Ruth C. Birbe; Rossitza A. Draganova-Tacheva; Tapio Visakorpi; Angelo M. DeMarzo; Steven B. McMahon; Karen E. Knudsen
Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Ilirjana Bajrami; Jessica R. Frankum; Asha Konde; Rowan E. Miller; Farah L. Rehman; Rachel Brough; James Campbell; David Sims; Rumana Rafiq; Sean Hooper; Lina Chen; Iwanka Kozarewa; Ioannis Assiotis; Kerry Fenwick; Rachael Natrajan; Christopher J. Lord; Alan Ashworth
Tumor and Stem Cell Biology
14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Sumaiyah K. Rehman; Shau-Hsuan Li; Shannon L. Wyszomierski; Qingfei Wang; Ping Li; Ozgur Sahin; Yi Xiao; Siyuan Zhang; Yan Xiong; Jun Yang; Hai Wang; Hua Guo; Jitao D. Zhang; Daniel Medina; William J. Muller; Dihua Yu
Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation
Laura R. Bohrer; Pavlina Chuntova; Lindsey K. Bade; Thomas C. Beadnell; Ronald P. Leon; Nicholas J. Brady; Yungil Ryu; Jodi E. Goldberg; Stephen C. Schmechel; Joseph S. Koopmeiners; James B. McCarthy; Kathryn L. Schwertfeger
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