Inactivation of the tumor suppressor p53 frequently occurs in tumors and tumor-associated stromal cells. This study shows that p53 dysfunction in tumor-associated stroma of B16F1 melanoma favors tumor establishment and progression by promoting an inflammatory microenvironment. Using immunofluoresence, it was found that lymphoid-like fibroblastic reticular cells, which express ER-TR7 (green), GP38 (red), and a-SMA (blue), were markedly expanded in the tumor microenvironment lacking functional p53. The expansion of this specialized stromal network was associated with augmented myeloid derived suppressor cells and angiogenesis. For details, see the article by Guo and colleagues on page 1668.