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15 December 2013
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The antitumor effects of histone deacetylase inhibitors (HDACi) are repressed in immunocompromised mice. Rag-2γ−/−mice transplanted with Eμ-myc B-cell lymphomas and treated with HDACi succumb significantly earlier than wild-type tumor-bearing mice and die with high splenic tumor burden as shown in this image (magnification, ×10). HDACi are able to inhibit their target enzymes and mediate tumor cell apoptosis in immunocompromised mice, however, in the absence of a functional immune system, the therapeutic efficacy of HDACi is significantly diminished. These data demonstrate the importance of a host immune system for sustained antitumor responses mediated by HDACi and indicate that these agents could be combined with immunotherapy to enhance efficacy. For details, see article by West and colleagues on page 7265.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Point–Counterpoint Reviews
Priority Report
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Integrated Systems and Technologies
Microenvironment and Immunology
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Molecular and Cellular Pathobiology
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Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology
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