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15 October 2013
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The prognosis and quality of life of patients with breast cancer brain metastases is generally poor and there is no effective treatment. A generally applicable computational model integrated with systems biology experiments was developed and applied to reposition existing drugs that would inhibit brain metastases. Ten repositioned drug candidates with potential brain permeability were identified. In xenograft models, sunitinib (approved for treating advanced renal cell carcinoma and gastrointestinal stromal tumors) and dasatinib (approved for treating chronic myelogenous leukemia) were repositioned to prevent metastatic outgrowth of breast cancer cells in the brain. For details, see article by Zhao and colleagues on page 6149.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Perspectives
Meeting Report
Priority Report
A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer
Raamesh Deshpande; Michael K. Asiedu; Mitchell Klebig; Shari Sutor; Elena Kuzmin; Justin Nelson; Jeff Piotrowski; Seung Ho Shin; Minoru Yoshida; Michael Costanzo; Charles Boone; Dennis A. Wigle; Chad L. Myers
Clinical Studies
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer
Yu-Peng Liu; Wen-Chi Liao; Luo-Ping Ger; Jiun-Chin Chen; Tai-I Hsu; Yu-Cheng Lee; Hong-Tai Chang; Yu-Chia Chen; Yi-Hua Jan; Kuen-Haur Lee; Yu-Hao Zeng; Michael Hsiao; Pei-Jung Lu
Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
Barbara S. Paugh; Xiaoyan Zhu; Chunxu Qu; Raelene Endersby; Alexander K. Diaz; Junyuan Zhang; Dorine A. Bax; Diana Carvalho; Rui M. Reis; Arzu Onar-Thomas; Alberto Broniscer; Cynthia Wetmore; Jinghui Zhang; Chris Jones; David W. Ellison; Suzanne J. Baker
Therapeutics, Targets, and Chemical Biology
EGFR-Activating Mutations Correlate with a Fanconi Anemia–like Cellular Phenotype That Includes PARP Inhibitor Sensitivity
Heike N. Pfäffle; Meng Wang; Liliana Gheorghiu; Natalie Ferraiolo; Patricia Greninger; Kerstin Borgmann; Jeffrey Settleman; Cyril H. Benes; Lecia V. Sequist; Lee Zou; Henning Willers
BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
Miguel F. Segura; Bárbara Fontanals-Cirera; Avital Gaziel-Sovran; María V. Guijarro; Doug Hanniford; Guangtao Zhang; Pilar González-Gomez; Marta Morante; Luz Jubierre; Weijia Zhang; Farbod Darvishian; Michael Ohlmeyer; Iman Osman; Ming-Ming Zhou; Eva Hernando
NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma
Zheng Huang; Haiping Wu; Shannon Chuai; Fiona Xu; Feng Yan; Nathan Englund; Zhaofu Wang; Hailong Zhang; Ming Fang; Youzhen Wang; Justin Gu; Man Zhang; Teddy Yang; Kehao Zhao; Yanyan Yu; Jingquan Dai; Wei Yi; Shaolian Zhou; Qian Li; Jing Wu; Jun Liu; Xu Wu; Homan Chan; Chris Lu; Peter Atadja; En Li; Yan Wang; Min Hu
Author Choice
Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer
Mohamed E. Abazeed; Drew J. Adams; Kristen E. Hurov; Pablo Tamayo; Chad J. Creighton; Dmitriy Sonkin; Andrew O. Giacomelli; Charles Du; Daniel F. Fries; Kwok-Kin Wong; Jill P. Mesirov; Jay S. Loeffler; Stuart L. Schreiber; Peter S. Hammerman; Matthew Meyerson
Tumor and Stem Cell Biology
Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Shirley L. Markant; Lourdes Adriana Esparza; Jesse Sun; Kelly L. Barton; Lisa M. McCoig; Gerald A. Grant; John R. Crawford; Michael L. Levy; Paul A. Northcott; David Shih; Marc Remke; Michael D. Taylor; Robert J. Wechsler-Reya
PLA2R1 Mediates Tumor Suppression by Activating JAK2
David Vindrieux; Arnaud Augert; Christophe A. Girard; Delphine Gitenay; Helene Lallet-Daher; Clotilde Wiel; Benjamin Le Calvé; Baptiste Gras; Mylène Ferrand; Stéphanie Verbeke; Yvan de Launoit; Xavier Leroy; Alain Puisieux; Sébastien Aubert; Michael Perrais; Michael Gelb; Hélène Simonnet; Gérard Lambeau; David Bernard
Correction
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