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Volume 73, Issue 15
1 August 2013
Cancer Research Cover Image for Volume 73, Issue 15
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  • Cover Image

    Cover Image

    issue cover
    Schematic representation of the IRE1α-dependent activation loop that controls tumor cell adaptation. Tumor cell is presented in light gray, stromal cells in dark gray. Proteins are represented by circles, with upregulation in green and downregulation in red. Connections following stress-mediated activation of IRE1α are presented in green for activation and red for inhibition. For details, see article by Pluquet and colleagues on page 4732.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
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Obituary

Emil Frei III, MD: In Memoriam (1924–2013)
John Laszlo
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Reviews

A Road Map to Comprehensive Androgen Receptor Axis Targeting for Castration-Resistant Prostate Cancer
Nicholas Mitsiades
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Myeloid-Derived Suppressor Cells as Osteoclast Progenitors: A Novel Target for Controlling Osteolytic Bone Metastasis
Anandi Sawant; Selvarangan Ponnazhagan
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Perspective

Cancer Research Advocacy: Past, Present, and Future
Jane Perlmutter; Shannon K. Bell; Gwen Darien
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Integrated Systems and Technologies

Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Norbert W. Lutz; Yann Le Fur; Johanna Chiche; Jacques Pouysségur; Patrick J. Cozzone
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Microenvironment and Immunology

Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment
Isabelle Le Mercier; Dominique Poujol; Amélien Sanlaville; Vanja Sisirak; Michael Gobert; Isabelle Durand; Bertrand Dubois; Isabelle Treilleux; Jacqueline Marvel; Jaromir Vlach; Jean-Yves Blay; Nathalie Bendriss-Vermare; Christophe Caux; Isabelle Puisieux; Nadège Goutagny
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Vaccine-Instructed Intratumoral IFN-γ Enables Regression of Autochthonous Mouse Prostate Cancer in Allogeneic T-Cell Transplantation
Rodrigo Hess Michelini; Teresa Manzo; Tabea Sturmheit; Veronica Basso; Martina Rocchi; Massimo Freschi; Joanna Listopad; Thomas Blankenstein; Matteo Bellone; Anna Mondino
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IL-18–Primed Helper NK Cells Collaborate with Dendritic Cells to Promote Recruitment of Effector CD8+ T Cells to the Tumor Microenvironment
Jeffrey L. Wong; Erik Berk; Robert P. Edwards; Pawel Kalinski
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Author Choice
Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab
Diane Goéré; Caroline Flament; Sylvie Rusakiewicz; Vichnou Poirier-Colame; Oliver Kepp; Isabelle Martins; Julien Pesquet; Alexander Eggermont; Dominique Elias; Nathalie Chaput; Laurence Zitvogel
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Author Choice
Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer
Max Nobis; Ewan J. McGhee; Jennifer P. Morton; Juliane P. Schwarz; Saadia A. Karim; Jean Quinn; Mike Edward; Andrew D. Campbell; Lynn C. McGarry; T.R. Jeffry Evans; Valerie G. Brunton; Margaret C. Frame; Neil O. Carragher; Yingxiao Wang; Owen J. Sansom; Paul Timpson; Kurt I. Anderson
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PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD
Arnab Ghosh; Amanda M. Holland; Yildirim Dogan; Nury L. Yim; Uttam K. Rao; Lauren F. Young; Mallory L. West; Natalie V. Singer; Hae Lee; Il-Kang Na; Jennifer J. Tsai; Robert R. Jenq; Olaf Penack; Alan M. Hanash; Cecilia Lezcano; George F. Murphy; Chen Liu; Michel Sadelain; Martin G. Sauer; Derek Sant'Angelo; Marcel R.M. van den Brink
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Author Choice
Progesterone Receptor Signaling in the Microenvironment of Endometrial Cancer Influences Its Response to Hormonal Therapy
Deanna M. Janzen; Miguel A. Rosales; Daniel Y. Paik; Daniel S. Lee; Daniel A. Smith; Owen N. Witte; M. Luisa Iruela-Arispe; Sanaz Memarzadeh
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Molecular and Cellular Pathobiology

Author Choice
Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Yu-Ching Teng; Cheng-Feng Lee; Ying-Shiuan Li; Yi-Ren Chen; Pei-Wen Hsiao; Meng-Yu Chan; Feng-Mao Lin; Hsien-Da Huang; Yen-Ting Chen; Yung-Ming Jeng; Chih-Hung Hsu; Qin Yan; Ming-Daw Tsai; Li-Jung Juan
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Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma
Kyle Muir; Antonious Hazim; Ying He; Marion Peyressatre; Do-Young Kim; Xiaoling Song; Laura Beretta
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Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IREα
Olivier Pluquet; Nicolas Dejeans; Marion Bouchecareilh; Stephanie Lhomond; Raphael Pineau; Arisa Higa; Maylis Delugin; Chantal Combe; Sandrine Loriot; Gaelle Cubel; Nathalie Dugot-Senant; Anne Vital; Hugues Loiseau; Sara J.C. Gosline; Said Taouji; Michael Hallett; Jann N. Sarkaria; Keith Anderson; Wenting Wu; Fausto J. Rodriguez; Jean Rosenbaum; Frédéric Saltel; Martin E. Fernandez-Zapico; Eric Chevet
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Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions
Doo Jae Lee; Dong Hoon Kang; Mina Choi; Yang Ji Choi; Joo Young Lee; Joo Hyun Park; Yoon Jung Park; Kyung Wha Lee; Sang Won Kang
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TR3 Modulates Platinum Resistance in Ovarian Cancer
Andrew J. Wilson; Annie Y. Liu; Joseph Roland; Oluwafunmilayo B. Adebayo; Sarah A. Fletcher; James C. Slaughter; Jeanette Saskowski; Marta A. Crispens; Howard W. Jones, III; Samuel James; Oluwole Fadare; Dineo Khabele
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Genetic Ablation of the Fatty Acid–Binding Protein FABP5 Suppresses HER2-Induced Mammary Tumorigenesis
Liraz Levi; Glenn Lobo; Mary Kathryn Doud; Johannes von Lintig; Darcie Seachrist; Gregory P. Tochtrop; Noa Noy
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PanIN-Specific Regulation of Wnt Signaling by HIF2α during Early Pancreatic Tumorigenesis
Angela Criscimanna; Li-Juan Duan; Julie A. Rhodes; Volker Fendrich; Emily Wickline; Douglas J. Hartman; Satdarshan P.S. Monga; Michael T. Lotze; George K. Gittes; Guo-Hua Fong; Farzad Esni
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Enhanced Radiation Sensitivity in HPV-Positive Head and Neck Cancer
Randall J. Kimple; Molly A. Smith; Grace C. Blitzer; Alexandra D. Torres; Joshua A. Martin; Robert Z. Yang; Chimera R. Peet; Laurel D. Lorenz; Kwangok P. Nickel; Aloysius J. Klingelhutz; Paul F. Lambert; Paul M. Harari
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Prevention and Epidemiology

Pathway-Based Serum microRNA Profiling and Survival in Patients with Advanced Stage Non–Small Cell Lung Cancer
Yan Wang; Jian Gu; Jack A. Roth; Michelle A.T. Hildebrandt; Scott M. Lippman; Yuanqing Ye; John D. Minna; Xifeng Wu
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A 20-Year Prospective Study of Plasma Prolactin as a Risk Marker of Breast Cancer Development
Shelley S. Tworoger; A. Heather Eliassen; Xuehong Zhang; Jing Qian; Patrick M. Sluss; Bernard A. Rosner; Susan E. Hankinson
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Therapeutics, Targets, and Chemical Biology

Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Denarda Dangaj; Evripidis Lanitis; Aizhi Zhao; Shree Joshi; Yi Cheng; Raphael Sandaltzopoulos; Hyun-Jeong Ra; Gwenn Danet-Desnoyers; Daniel J. Powell, Jr; Nathalie Scholler
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Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p
Stéphanie Solier; Michael C. Ryan; Scott E. Martin; Sudhir Varma; Kurt W. Kohn; Hongfang Liu; Barry R. Zeeberg; Yves Pommier
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Author Choice
C-RAF Mutations Confer Resistance to RAF Inhibitors
Rajee Antony; Caroline M. Emery; Allison M. Sawyer; Levi A. Garraway
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Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Aurélie Chantôme; Marie Potier-Cartereau; Lucie Clarysse; Gaëlle Fromont; Séverine Marionneau-Lambot; Maxime Guéguinou; Jean-Christophe Pagès; Christine Collin; Thibauld Oullier; Alban Girault; Flavie Arbion; Jean-Pierre Haelters; Paul-Alain Jaffrès; Michelle Pinault; Pierre Besson; Virginie Joulin; Philippe Bougnoux; Christophe Vandier
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Docetaxel Conjugate Nanoparticles That Target α-Smooth Muscle Actin–Expressing Stromal Cells Suppress Breast Cancer Metastasis
Mami Murakami; Mark J. Ernsting; Elijus Undzys; Nathan Holwell; Warren D. Foltz; Shyh-Dar Li
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Tumor and Stem Cell Biology

LIN28 Expression in Malignant Germ Cell Tumors Downregulates let-7 and Increases Oncogene Levels
Matthew J. Murray; Harpreet K. Saini; Charlotte A. Siegler; Jennifer E. Hanning; Emily M. Barker; Stijn van Dongen; Dawn M. Ward; Katie L. Raby; Ian J. Groves; Cinzia G. Scarpini; Mark R. Pett; Claire M. Thornton; Anton J. Enright; James C. Nicholson; Nicholas Coleman; on behalf of the CCLG
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Author Choice
A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models
Xiaomei Zhang; Sofie Claerhout; Aleix Prat; Lacey E. Dobrolecki; Ivana Petrovic; Qing Lai; Melissa D. Landis; Lisa Wiechmann; Rachel Schiff; Mario Giuliano; Helen Wong; Suzanne W. Fuqua; Alejandro Contreras; Carolina Gutierrez; Jian Huang; Sufeng Mao; Anne C. Pavlick; Amber M. Froehlich; Meng-Fen Wu; Anna Tsimelzon; Susan G. Hilsenbeck; Edward S. Chen; Pavel Zuloaga; Chad A. Shaw; Mothaffar F. Rimawi; Charles M. Perou; Gordon B. Mills; Jenny C. Chang; Michael T. Lewis
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eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes
Jianling Yang; Jun Wang; Ke Chen; Guijie Guo; Ruijiao Xi; Paul B. Rothman; Douglas Whitten; Lianfeng Zhang; Shile Huang; Ji-Long Chen
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Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
Yaqing Zhang; John P. Morris, IV; Wei Yan; Heather K. Schofield; Austin Gurney; Diane M. Simeone; Sarah E. Millar; Timothy Hoey; Matthias Hebrok; Marina Pasca di Magliano
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Aptamer Identification of Brain Tumor–Initiating Cells
Youngmi Kim; Qiulian Wu; Petra Hamerlik; Masahiro Hitomi; Andrew E. Sloan; Gene H. Barnett; Robert J. Weil; Patrick Leahy; Anita B. Hjelmeland; Jeremy N. Rich
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Author Choice
Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling
Ron C.J. Schackmann; Sjoerd Klarenbeek; Eva J. Vlug; Suzan Stelloo; Miranda van Amersfoort; Milou Tenhagen; Tanya M. Braumuller; Jeroen F. Vermeulen; Petra van der Groep; Ton Peeters; Elsken van der Wall; Paul J. van Diest; Jos Jonkers; Patrick W.B. Derksen
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TRAF6 Upregulates Expression of HIF-1α and Promotes Tumor Angiogenesis
Heng Sun; Xue-Bing Li; Ya Meng; Li Fan; Min Li; Jing Fang
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Retraction

Retraction: Sp100 as a Potent Tumor Suppressor: Accelerated Senescence and Rapid Malignant Transformation of Human Fibroblasts through Modulation of an Embryonic Stem Cell Program
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Correction

Correction: IKK4a/ARF Inactivation with Activation of the NF-κB/IL-6 Pathway Is Sufficient to Drive the Development and Growth of Angiosarcoma
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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