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15 April 2012
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The HIV-1 TAT peptide was dimerized and used to formulate a nanoparticle vector (dTAT NP) to leverage efficient tumor-targeted gene delivery following intratracheal administration. In vitro expression efficiency for dTAT NP–encapsulated luciferase or angiotensin II type 2 receptor (AT2R) plasmid DNA (pDNA) revealed effective pDNA transfection with negligible cytotoxicity. In orthotopic tumor grafts, immunohistochemical analysis confirmed that dTAT NP successfully delivered pDNA to the tumor, and gene expression in tumor tissues persisted at least 14 days after intratracheal administration. Bolus administration of dTAT NP–encapsulated AT2R or TRAIL pDNA, both endogenous apoptosis inducers, markedly attenuated tumor growth. For details, see article by Kawabata and colleagues on page 2057 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Priority Reports
Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Yan W. Asmann; Brian M. Necela; Krishna R. Kalari; Asif Hossain; Tiffany R. Baker; Jennifer M. Carr; Caroline Davis; Julie E. Getz; Galen Hostetter; Xing Li; Sarah A. McLaughlin; Derek C. Radisky; Gary P. Schroth; Heather E. Cunliffe; Edith A. Perez; E. Aubrey Thompson
Integrated Systems and Technologies
Microenvironment and Immunology
Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma
Martin A. Thelin; Katrin J. Svensson; Xiaofeng Shi; Mariam Bagher; Jakob Axelsson; Anna Isinger-Ekstrand; Toin H. van Kuppevelt; Jan Johansson; Mef Nilbert; Joseph Zaia; Mattias Belting; Marco Maccarana; Anders Malmström
Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization
Sònia Tugues; Satoshi Honjo; Christian König; Oriol Noguer; Marie Hedlund; Johan Botling; Sofie Deschoemaeker; Mathias Wenes; Charlotte Rolny; Wilhelm Jahnen-Dechent; Massimiliano Mazzone; Lena Claesson-Welsh
Molecular and Cellular Pathobiology
Prevention and Epidemiology
Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci
Carolyn M. Hutter; Jenny Chang-Claude; Martha L. Slattery; Bethann M. Pflugeisen; Yi Lin; David Duggan; Hongmei Nan; Mathieu Lemire; Jagadish Rangrej; Jane C. Figueiredo; Shuo Jiao; Tabitha A. Harrison; Yan Liu; Lin S. Chen; Deanna L. Stelling; Greg S. Warnick; Michael Hoffmeister; Sébastien Küry; Charles S. Fuchs; Edward Giovannucci; Aditi Hazra; Peter Kraft; David J. Hunter; Steven Gallinger; Brent W. Zanke; Hermann Brenner; Bernd Frank; Jing Ma; Cornelia M. Ulrich; Emily White; Polly A. Newcomb; Charles Kooperberg; Andrea Z. LaCroix; Ross L. Prentice; Rebecca D. Jackson; Robert E. Schoen; Stephen J. Chanock; Sonja I. Berndt; Richard B. Hayes; Bette J. Caan; John D. Potter; Li Hsu; Stéphane Bézieau; Andrew T. Chan; Thomas J. Hudson; Ulrike Peters
Therapeutics, Targets, and Chemical Biology
AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
Paul R. Gavine; Lorraine Mooney; Elaine Kilgour; Andrew P. Thomas; Katherine Al-Kadhimi; Sarah Beck; Claire Rooney; Tanya Coleman; Dawn Baker; Martine J. Mellor; A. Nigel Brooks; Teresa Klinowska
Common Variation at BARD1 Results in the Expression of an Oncogenic Isoform That Influences Neuroblastoma Susceptibility and Oncogenicity
Kristopher R. Bosse; Sharon J. Diskin; Kristina A. Cole; Andrew C. Wood; Robert W. Schnepp; Geoffrey Norris; Le B. Nguyen; Jayanti Jagannathan; Michael Laquaglia; Cynthia Winter; Maura Diamond; Cuiping Hou; Edward F. Attiyeh; Yael P. Mosse; Vanessa Pineros; Eva Dizin; Yongqiang Zhang; Shahab Asgharzadeh; Robert C. Seeger; Mario Capasso; Bruce R. Pawel; Marcella Devoto; Hakon Hakonarson; Eric F. Rappaport; Irmgard Irminger-Finger; John M. Maris
Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice
Vincent Hurez; Benjamin J. Daniel; Lishi Sun; Ai-Jie Liu; Sara M. Ludwig; Mark J. Kious; Suzanne R. Thibodeaux; Srilakshmi Pandeswara; Kruthi Murthy; Carolina B. Livi; Shawna Wall; Michael J. Brumlik; Tahiro Shin; Bin Zhang; Tyler J. Curiel
Tumor and Stem Cell Biology
Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability
Sophia B. Chernikova; Olga V. Razorenova; John P. Higgins; Brock J. Sishc; Monica Nicolau; Jennifer A. Dorth; Diana A. Chernikova; Shirley Kwok; James D. Brooks; Susan M. Bailey; John C. Game; J. Martin Brown
Expression of a Truncated Active Form of VDAC1 in Lung Cancer Associates with Hypoxic Cell Survival and Correlates with Progression to Chemotherapy Resistance
M. Christiane Brahimi-Horn; Danya Ben-Hail; Marius Ilie; Pierre Gounon; Matthieu Rouleau; Véronique Hofman; Jérôme Doyen; Bernard Mari; Varda Shoshan-Barmatz; Paul Hofman; Jacques Pouysségur; Nathalie M. Mazure
Corrections
Obituary
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