Squamous cell carcinomas of the uterine cervix were subjected to dynamic contrast-enhanced magnetic resonance imaging by using gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA) as contrast agent and an axial T₁-weighted spoiled gradient recalled sequence for imaging. The T₁-weighted images showed a high-signal intensity rim in the tumor periphery immediately after the contrast administration, and this rim moved outwards with time. The velocity of the rim movement at the tumor surface was associated with tumor interstitial fluid pressure and incidence of lymph node metastases, and may serve as a novel general biomarker of interstitial hypertension-induced tumor aggressiveness. For details, see article by Hompland and colleagues on page 4899.