Complete tumor eradication by thermal ablation therapy alone is often difficult because of sub-lethal thermal dose in some areas of the tumor. For photothermal ablation therapy, it is highly desirable to selectively deliver combined thermal ablation therapy and other treatment modalities such as chemotherapy through a single nanodevice. Using doxorubicin-loaded hollow gold nanospheres conjugated with a high-affinity cyclic peptide recognizing EphB4 receptors, it was found that targeted nanoparticles displayed significantly higher tumor uptakes than nanoparticles without peptidyl homing ligands. Moreover, treatment with near-infrared laser led to synergistic antitumor effect without increased toxicities in a preclinical mouse model. For details, see article by You and colleagues on page 4777.