Rescue of a common ABCG2 variant by the HDAC inhibitor romidepsin. While the drug efflux transporter ABCG2 is expressed at the cell surface in transfected Flp-In-293 cells, its Q141K variant is trapped in the aggresome, an intracellular structure where misfolded proteins accumulate. Flp-In-293 cells expressing the Q141K variant were treated with romidepsin for 24 h, after which, immunofluorescence staining was done for ABCG2 (red), the aggresome marker γ-tubulin (green), and nuclei (blue). Romidepsin induced a drastic change in variant protein localization, from aggresome to the cell surface. This was accompanied by an increase in expression and a restoration of ABCG2-mediated drug efflux activity. For details, see article by Basseville and colleagues on page 3642 of this issue.