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Volume 72, Issue 1

1 January 2012

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Cover Image

Cover Image

Brain metastases of breast and other cancers are increasing in incidence and limiting the gains made by systemic therapy. Here, brain-tropic human metastatic breast cancer cells overexpressing pigment epithelium–derived factor rapidly became apoptotic when implanted into a mouse brain. Red, human mitochondria (tumor cells); green, cleaved caspase-3 stain (apoptosis); blue, DAPI. For details, see the article by Fitzgerald and colleagues on page 144 of this issue.
Table of Contents

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Advances
Reviews
Perspective
Clinical Studies
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology
Correction

Cancer Research

Breaking Advances

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Reviews

Targeting the Insulin-like Growth Factor Axis for the Development of Novel Therapeutics in Oncology

Jin Gao; Yong S. Chang; Bahija Jallal; Jaye Viner

Abstract

View articletitled, Targeting the Insulin-like Growth Factor Axis for the Development of Novel Therapeutics in Oncology

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Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage

Anup K. Biswas; David G. Johnson

Abstract

View articletitled, Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage

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Perspective

Finding a Panacea among Combination Cancer Therapies

Ryuji Yamaguchi; Guy Perkins

Abstract

View articletitled, Finding a Panacea among Combination Cancer Therapies

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Clinical Studies

Immunomonitoring Results of a Phase II/III Study of Malignant Ascites Patients Treated with the Trifunctional Antibody Catumaxomab (Anti-EpCAM × Anti-CD3)

Michael Jäger; Alexandra Schoberth; Peter Ruf; Juergen Hess; Michael Hennig; Barbara Schmalfeldt; Pauline Wimberger; Michael Ströhlein; Bettina Theissen; Markus M. Heiss; Horst Lindhofer

Abstracts

View articletitled, Immunomonitoring Results of a Phase II/III Study of Malignant Ascites Patients Treated with the Trifunctional Antibody Catumaxomab (Anti-EpCAM × Anti-CD3)

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Integrated Systems and Technologies

A Novel Method of Transcriptional Response Analysis to Facilitate Drug Repositioning for Cancer Therapy

Guangxu Jin; Changhe Fu; Hong Zhao; Kemi Cui; Jenny Chang; Stephen T.C. Wong

Abstracts

View articletitled, A Novel Method of Transcriptional Response Analysis to Facilitate Drug Repositioning for Cancer Therapy

Supplementary data

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Microenvironment and Immunology

Defective NF-κB Signaling in Metastatic Head and Neck Cancer Cells Leads to Enhanced Apoptosis by Double-Stranded RNA

Naoki Umemura; Jianzhong Zhu; Yvonne K. Mburu; Adriana Forero; Paishiun N. Hsieh; Ravikumar Muthuswamy; Pawel Kalinski; Robert L. Ferris; Saumendra N. Sarkar

Abstracts

View articletitled, Defective NF-κB Signaling in Metastatic Head and Neck Cancer Cells Leads to Enhanced Apoptosis by Double-Stranded RNA

Supplementary data

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ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-αvβ3–Dependent Mechanisms

Masahisa Jinushi; Shigeki Chiba; Muhammad Baghdadi; Ichiro Kinoshita; Hirotoshi Dosaka-Akita; Koyu Ito; Hironori Yoshiyama; Hideo Yagita; Toshimitsu Uede; Akinori Takaoka

Abstracts

View articletitled, ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-αvβ3–Dependent Mechanisms

Supplementary data

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A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Hagen Kulbe; Probir Chakravarty; D. Andrew Leinster; Kellie A. Charles; Joseph Kwong; Richard G. Thompson; Jermaine I. Coward; Tiziana Schioppa; Stephen C. Robinson; William M. Gallagher; Laura Galletta; on behalf of the Australian Ovarian Cancer Study Group; Michael A. Salako; John F. Smyth; Thorsten Hagemann; Donal J. Brennan; David D. Bowtell; Frances R. Balkwill

Abstracts

View articletitled, A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Supplementary data

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Activated STAT5 Promotes Long-Lived Cytotoxic CD8⁺ T Cells That Induce Regression of Autochthonous Melanoma

Magali Grange; Michel Buferne; Grégory Verdeil; Lee Leserman; Anne-Marie Schmitt-Verhulst; Nathalie Auphan-Anezin

Abstracts

View articletitled, Activated STAT5 Promotes Long-Lived Cytotoxic CD8+ T Cells That Induce Regression of Autochthonous Melanoma

Supplementary data

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Molecular and Cellular Pathobiology

GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells

Simon Joost; Luciana L. Almada; Verena Rohnalter; Philipp S. Holz; Anne M. Vrabel; Maite G. Fernandez-Barrena; Robert R. McWilliams; Michael Krause; Martin E. Fernandez-Zapico; Matthias Lauth

Abstracts

View articletitled, GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells

Supplementary data

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Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

Hirokazu Okayama; Takashi Kohno; Yuko Ishii; Yoko Shimada; Kouya Shiraishi; Reika Iwakawa; Koh Furuta; Koji Tsuta; Tatsuhiro Shibata; Seiichiro Yamamoto; Shun-ichi Watanabe; Hiromi Sakamoto; Kensuke Kumamoto; Seiichi Takenoshita; Noriko Gotoh; Hideaki Mizuno; Akinori Sarai; Shuichi Kawano; Rui Yamaguchi; Satoru Miyano; Jun Yokota

Abstracts

View articletitled, Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

Supplementary data

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Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets

Vijay R. Dondeti; Bradley Wubbenhorst; Priti Lal; John D. Gordan; Kurt D'Andrea; Edward F. Attiyeh; M. Celeste Simon; Katherine L. Nathanson

Abstracts

View articletitled, Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets

Supplementary data

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CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog–Driven Medulloblastoma

Rajarshi Sengupta; Adrian Dubuc; Stacey Ward; Lihua Yang; Paul Northcott; B. Mark Woerner; Kirsten Kroll; Jingqin Luo; Michael D. Taylor; Robert J. Wechsler-Reya; Joshua B. Rubin

Abstracts

View articletitled, CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog–Driven Medulloblastoma

Supplementary data

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Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis

Stuart G. Jarrett; Marian Novak; Sandrine Dabernat; Jean-Yves Daniel; Isabel Mellon; Qingbei Zhang; Nathan Harris; Michael J. Ciesielski; Robert A. Fenstermaker; Diane Kovacic; Andrzej Slominski; David M. Kaetzel

Abstracts

View articletitled, Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis

Supplementary data

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Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Daniel P. Fitzgerald; Preeti Subramanian; Monika Deshpande; Christian Graves; Ira Gordon; Yongzhen Qian; Yeva Snitkovsky; David J. Liewehr; Seth M. Steinberg; José D. Paltán-Ortiz; Mary M. Herman; Kevin Camphausen; Diane Palmieri; S. Patricia Becerra; Patricia S. Steeg

Abstracts

View articletitled, Opposing Effects of Pigment Epithelium–Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage

Supplementary data

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A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer

Ning Li; Sippy Kaur; Joel Greshock; Heini Lassus; Xiaomin Zhong; Yanling Wang; Arto Leminen; Zhongjun Shao; Xiaowen Hu; Shun Liang; Dionyssios Katsaros; Qihong Huang; Ralf Bützow; Barbara L. Weber; George Coukos; Lin Zhang

Abstracts

View articletitled, A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer

Supplementary data

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Contrasting Behavior of the p18^INK4c and p16^INK4a Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence

Sladjana Gagrica; Sharon Brookes; Emma Anderton; Janice Rowe; Gordon Peters

Abstracts

View articletitled, Contrasting Behavior of the p18INK4c and p16INK4a Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence

Supplementary data

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Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer

Sandra D. Castillo; Ander Matheu; Niccolo Mariani; Julian Carretero; Fernando Lopez-Rios; Robin Lovell-Badge; Montse Sanchez-Cespedes

Abstracts

View articletitled, Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer

Supplementary data

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Therapeutics, Targets, and Chemical Biology

Autocrine CSF-1 and CSF-1 Receptor Coexpression Promotes Renal Cell Carcinoma Growth

Julia Menke; Jörg Kriegsmann; Carl Christoph Schimanski; Melvin M. Schwartz; Andreas Schwarting; Vicki R. Kelley

Abstracts

View articletitled, Autocrine CSF-1 and CSF-1 Receptor Coexpression Promotes Renal Cell Carcinoma Growth

Supplementary data

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Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

Dirk Spitzer; Peter O. Simon, Jr; Hiroyuki Kashiwagi; Jinbin Xu; Chenbo Zeng; Suwanna Vangveravong; Dong Zhou; Katherine Chang; Jonathan E. McDunn; John R. Hornick; Peter Goedegebuure; Richard S. Hotchkiss; Robert H. Mach; William G. Hawkins

Abstracts

View articletitled, Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling

Supplementary data

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Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth Inhibition

Klaus P. Hoeflich; Mark Merchant; Christine Orr; Jocelyn Chan; Doug Den Otter; Leanne Berry; Ian Kasman; Hartmut Koeppen; Ken Rice; Nai-Ying Yang; Stefan Engst; Stuart Johnston; Lori S. Friedman; Marcia Belvin

Abstracts

View articletitled, Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth Inhibition

Supplementary data

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Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer

Damian McCartan; Jarlath C. Bolger; Aílis Fagan; Christopher Byrne; Yuan Hao; Li Qin; Marie McIlroy; Jianming Xu; Arnold D. Hill; Peadar Ó Gaora; Leonie S. Young

Abstracts

View articletitled, Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer

Supplementary data

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HMGB1 Promotes Drug Resistance in Osteosarcoma

Jun Huang; Jiangdong Ni; Ke Liu; Yan Yu; Min Xie; Rui Kang; Philip Vernon; Lizhi Cao; Daolin Tang

Abstracts

View articletitled, HMGB1 Promotes Drug Resistance in Osteosarcoma

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Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

Emmanouil Fokas; Jae Hong Im; Sally Hill; Sabira Yameen; Michael Stratford; John Beech; Wolfgang Hackl; Sauveur-Michel Maira; Eric J. Bernhard; W. Gillies McKenna; Ruth J. Muschel

Abstracts

View articletitled, Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

Supplementary data

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Expression and Function of Survivin in Canine Osteosarcoma

Jenette K. Shoeneman; E.J. Ehrhart, III; Jens C. Eickhoff; J.B. Charles; Barbara E. Powers; Douglas H. Thamm

Abstracts

View articletitled, Expression and Function of Survivin in Canine Osteosarcoma

Supplementary data

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Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

Jixia Li; Margarita Malakhova; Madhusoodanan Mottamal; Kanamata Reddy; Igor Kurinov; Andria Carper; Alyssa Langfald; Naomi Oi; Myoung Ok Kim; Feng Zhu; Carlos P. Sosa; Keyuan Zhou; Ann M. Bode; Zigang Dong

Abstracts

View articletitled, Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

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Genetically Modified T cells Targeting Interleukin-11 Receptor α-Chain Kill Human Osteosarcoma Cells and Induce the Regression of Established Osteosarcoma Lung Metastases

Gangxiong Huang; Ling Yu; Laurence J.N. Cooper; Mario Hollomon; Helen Huls; Eugenie S. Kleinerman

Abstracts

View articletitled, Genetically Modified T cells Targeting Interleukin-11 Receptor α-Chain Kill Human Osteosarcoma Cells and Induce the Regression of Established Osteosarcoma Lung Metastases

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Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

Dongping Wei; Hua Li; Jie Yu; Jonathan T. Sebolt; Lili Zhao; Theodore S. Lawrence; Peter G. Smith; Meredith A. Morgan; Yi Sun

Abstracts

View articletitled, Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor

Supplementary data

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Pim Kinase Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Triggered by Bcl-2 Family Inhibitor ABT-737

Jin H. Song; Andrew S. Kraft

Abstracts

View articletitled, Pim Kinase Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Triggered by Bcl-2 Family Inhibitor ABT-737

Supplementary data

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Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

Yunfei Zhou; Federico Tozzi; Jinyu Chen; Fan Fan; Ling Xia; Jinrong Wang; Guang Gao; Aijun Zhang; Xuefeng Xia; Heather Brasher; William Widger; Lee M. Ellis; Zhang Weihua

Abstracts

View articletitled, Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

Supplementary data

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Tumor and Stem Cell Biology

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

Chunxi Wang; Zhihui Liu; Chan-Wook Woo; Zhijie Li; Lifeng Wang; Jun S. Wei; Victor E. Marquez; Susan E. Bates; Qihuang Jin; Javed Khan; Kai Ge; Carol J. Thiele

Abstracts

View articletitled, EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

Supplementary data

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The White Adipose Tissue Used in Lipotransfer Procedures Is a Rich Reservoir of CD34⁺ Progenitors Able to Promote Cancer Progression

Ines Martin-Padura; Giuliana Gregato; Paola Marighetti; Patrizia Mancuso; Angelica Calleri; Chiara Corsini; Giancarlo Pruneri; Michela Manzotti; Visnu Lohsiriwat; Mario Rietjens; Jean-Yves Petit; Francesco Bertolini

Abstracts

View articletitled, The White Adipose Tissue Used in Lipotransfer Procedures Is a Rich Reservoir of CD34+ Progenitors Able to Promote Cancer Progression

Supplementary data

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Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression

Bin Bao; Shadan Ali; Sanjeev Banerjee; Zhiwei Wang; Farah Logna; Asfar S. Azmi; Dejuan Kong; Aamir Ahmad; Yiwei Li; Subhash Padhye; Fazlul H. Sarkar

Abstracts

View articletitled, Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression

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Mesenchymal Stromal Cell Mutations and Wound Healing Contribute to the Etiology of Desmoid Tumors

Adelaide M. Carothers; Hira Rizvi; Rian M. Hasson; Yvonne I. Heit; Jennifer S. Davids; Monica M. Bertagnolli; Nancy L. Cho

Abstracts

View articletitled, Mesenchymal Stromal Cell Mutations and Wound Healing Contribute to the Etiology of Desmoid Tumors

Supplementary data

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Metabolomic NMR Fingerprinting to Identify and Predict Survival of Patients with Metastatic Colorectal Cancer

Ivano Bertini; Stefano Cacciatore; Benny V. Jensen; Jakob V. Schou; Julia S. Johansen; Mogens Kruhøffer; Claudio Luchinat; Dorte L. Nielsen; Paola Turano

Abstracts

View articletitled, Metabolomic NMR Fingerprinting to Identify and Predict Survival of Patients with Metastatic Colorectal Cancer

Supplementary data

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ERK1/2 Regulation of CD44 Modulates Oral Cancer Aggressiveness

Nancy P. Judd; Ashley E. Winkler; Oihana Murillo-Sauca; Joshua J. Brotman; Jonathan H. Law; James S. Lewis, Jr; Gavin P. Dunn; Jack D. Bui; John B. Sunwoo; Ravindra Uppaluri

Abstracts

View articletitled, ERK1/2 Regulation of CD44 Modulates Oral Cancer Aggressiveness

Supplementary data

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Correction

Correction: LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide–Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors

Extract

View articletitled, Correction: LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide–Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cancer Research

Table of Contents

Breaking Advances

Reviews

Perspective

Clinical Studies

Integrated Systems and Technologies

Microenvironment and Immunology

Molecular and Cellular Pathobiology

Therapeutics, Targets, and Chemical Biology

Tumor and Stem Cell Biology

Correction

Journal Archive

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