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Issues

Volume 71, Issue 7
1 April 2011
Cancer Research Cover Image for Volume 71, Issue 7
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  • Cover Image

    Cover Image

    issue cover
    Lactate stimulates IL-8-dependent angiogenesis. Representative photograph of tube formation in lactate-containing medium from Matrigel-plated endothelial cells. For details, see the article by Végran and colleagues on page 2550 of this issue
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
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Reviews

Tumor-Associated Neutrophils: New Targets for Cancer Therapy
Alyssa D. Gregory; A. McGarry Houghton
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BRAFV600E and Microenvironment in Thyroid Cancer: A Functional Link to Drive Cancer Progression
Carmelo Nucera; Jack Lawler; Sareh Parangi
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Priority Reports

Functional EGFR Germline Polymorphisms May Confer Risk for EGFR Somatic Mutations in Non–Small Cell Lung Cancer, with a Predominant Effect on Exon 19 Microdeletions
Wanqing Liu; Lijun He; Jacqueline Ramírez; Soundararajan Krishnaswamy; Rajani Kanteti; Yi-Ching Wang; Ravi Salgia; Mark J. Ratain
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Novel Human Single Chain Antibody Fragments That Are Rapidly Internalizing Effectively Target Epithelioid and Sarcomatoid Mesotheliomas
Arun K. Iyer; Xiaoli Lan; Xiaodong Zhu; Yang Su; Jinjin Feng; Xiaoju Zhang; Dongwei Gao; Youngho Seo; Henry F. VanBrocklin; V. Courtney Broaddus; Bin Liu; Jiang He
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Integrated Systems and Technologies

Integration of Genotypic and Phenotypic Screening Reveals Molecular Mediators of Melanoma–Stromal Interaction
Megan J. Stine; C. Joanne Wang; Whei F. Moriarty; Byungwoo Ryu; Raymond Cheong; William H. Westra; Andre Levchenko; Rhoda M. Alani
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Microenvironment and Immunology

Abrogating TNF-α Expression Prevents Bystander Destruction of Normal Tissues during iNOS-Mediated Elimination of Intraocular Tumors
Terry G. Coursey; Peter W. Chen; Jerry Y. Niederkorn
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Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
Béatrice Dirat; Ludivine Bochet; Marta Dabek; Danièle Daviaud; Stéphanie Dauvillier; Bilal Majed; Yuan Yuan Wang; Aline Meulle; Bernard Salles; Sophie Le Gonidec; Ignacio Garrido; Ghislaine Escourrou; Philippe Valet; Catherine Muller
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Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth
Zhenyu Cai; Amir Sanchez; Zhongcheng Shi; Tingting Zhang; Mingyao Liu; Dekai Zhang
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Diagnosis of Prostate Cancer Using Differentially Expressed Genes in Stroma
Zhenyu Jia; Yipeng Wang; Anne Sawyers; Huazhen Yao; Farahnaz Rahmatpanah; Xiao-Qin Xia; Qiang Xu; Rebecca Pio; Tolga Turan; James A. Koziol; Steve Goodison; Philip Carpenter; Jessica Wang-Rodriguez; Anne Simoneau; Frank Meyskens; Manuel Sutton; Waldemar Lernhardt; Thomas Beach; Joseph Monforte; Michael McClelland; Dan Mercola
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The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity
Byron C. Burnette; Hua Liang; Youjin Lee; Lukasz Chlewicki; Nikolai N. Khodarev; Ralph R. Weichselbaum; Yang-Xin Fu; Sogyong L. Auh
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IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-Infected Dendritic Cells
Jeanette E. Boudreau; Kyle B. Stephenson; Fuan Wang; Ali A. Ashkar; Karen L. Mossman; Laurel L. Lenz; Kenneth L. Rosenthal; Jonathan L. Bramson; Brian D. Lichty; Yonghong Wan
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Absence of Class II–Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells
Marvin M. van Luijn; Willemijn van den Ancker; Martine E.D. Chamuleau; Adri Zevenbergen; Theresia M. Westers; Gert J. Ossenkoppele; S. Marieke van Ham; Arjan A. van de Loosdrecht
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Molecular and Cellular Pathobiology

Estrogen-Related Receptor Gamma Promotes Mesenchymal-to-Epithelial Transition and Suppresses Breast Tumor Growth
Claire Tiraby; Bethany C. Hazen; Marin L. Gantner; Anastasia Kralli
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Helicobacter hepaticus–Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response
Alexis García; Yu Zeng; Sureshkumar Muthupalani; Zhongming Ge; Amanda Potter; Melissa W. Mobley; Chakib Boussahmain; Yan Feng; John S. Wishnok; James G. Fox
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Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo
Ken Sasai; Taiko Sukezane; Emmy Yanagita; Harumi Nakagawa; Azusa Hotta; Tomoo Itoh; Tsuyoshi Akagi
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Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
Frédérique Végran; Romain Boidot; Carine Michiels; Pierre Sonveaux; Olivier Feron
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Integrative Genomics Identifies Molecular Alterations that Challenge the Linear Model of Melanoma Progression
Amy E. Rose; Laura Poliseno; Jinhua Wang; Michael Clark; Alexander Pearlman; Guimin Wang; Eleazar C. Vega y Saenz de Miera; Ratna Medicherla; Paul J. Christos; Richard Shapiro; Anna Pavlick; Farbod Darvishian; Jiri Zavadil; David Polsky; Eva Hernando; Harry Ostrer; Iman Osman
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Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer
Marcus W. Butler; Tomoya Fukui; Jacqueline Salit; Renat Shaykhiev; Jason G. Mezey; Neil R. Hackett; Ronald G. Crystal
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MicroRNA-95 Promotes Cell Proliferation and Targets Sorting Nexin 1 in Human Colorectal Carcinoma
Zhaohui Huang; Shenglin Huang; Qifeng Wang; Linhui Liang; Shujuan Ni; Lisha Wang; Weiqi Sheng; Xianghuo He; Xiang Du
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S6 Kinase 2 Promotes Breast Cancer Cell Survival via Akt
Savitha Sridharan; Alakananda Basu
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β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells
Sajni Josson; Takeo Nomura; Jen-Tai Lin; Wen-Chin Huang; Daqing Wu; Haiyen E. Zhau; Majd Zayzafoon; M. Neale Weizmann; Murali Gururajan; Leland W. K. Chung
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MicroRNA-205 Inhibits Src-Mediated Oncogenic Pathways in Renal Cancer
Shahana Majid; Sharanjot Saini; Altaf A. Dar; Hiroshi Hirata; Varahram Shahryari; Yuichiro Tanaka; Soichiro Yamamura; Koji Ueno; Mohd Saif Zaman; Kamaldeep Singh; Inik Chang; Guoren Deng; Rajvir Dahiya
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Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts
Jinghai Wu; Robert T. Dauchy; Paul C. Tirrell; Steven S. Wu; Darin T. Lynch; Potjana Jitawatanarat; Christine M. Burrington; Erin M. Dauchy; David E. Blask; Michael W. Greene
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Therapeutics, Targets, and Chemical Biology

MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers
Eduardo Vilar; Catherine M. Bartnik; Stephanie L. Stenzel; Leon Raskin; Jaeil Ahn; Victor Moreno; Bhramar Mukherjee; Maria D. Iniesta; Meredith A. Morgan; Gad Rennert; Stephen B. Gruber
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Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas
Tara L. Naylor; Huaping Tang; Boris A. Ratsch; Andreas Enns; Alice Loo; Liqing Chen; Peter Lenz; Nigel J. Waters; Walter Schuler; Bernd Dörken; Yung-mae Yao; Markus Warmuth; Georg Lenz; Frank Stegmeier
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eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206
Yan Cheng; Xingcong Ren; Yi Zhang; Rajesh Patel; Arati Sharma; Hao Wu; Gavin P. Robertson; Li Yan; Eric Rubin; Jin-Ming Yang
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COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells
Mitsugu Fujita; Gary Kohanbash; Wendy Fellows-Mayle; Ronald L. Hamilton; Yoshihiro Komohara; Stacy A. Decker; John R. Ohlfest; Hideho Okada
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Antiangiogenesis Enhances Intratumoral Drug Retention
Jie Ma; Chong-Sheng Chen; Todd Blute; David J. Waxman
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Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming
Brian E. Schwartz; Matthias D. Hofer; Madeleine E. Lemieux; Daniel E. Bauer; Michael J. Cameron; Nathan H. West; Elin S. Agoston; Nicolas Reynoird; Saadi Khochbin; Tan A. Ince; Amanda Christie; Katherine A. Janeway; Sara O. Vargas; Antonio R. Perez-Atayde; Jon C. Aster; Stephen E. Sallan; Andrew L. Kung; James E. Bradner; Christopher A. French
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Expression Profiling of Liposarcoma Yields a Multigene Predictor of Patient Outcome and Identifies Genes That Contribute to Liposarcomagenesis
Ryan M. Gobble; Li-Xuan Qin; Elliott R. Brill; Christina V. Angeles; Stacy Ugras; Rachael B. O'Connor; Nicole H. Moraco; Penelope L. DeCarolis; Cristina Antonescu; Samuel Singer
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Tumor and Stem Cell Biology

Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation
Jessica R. Adams; Keli Xu; Jeff C. Liu; Natalia M. Ruiz Agamez; Amanda J. Loch; Ruth G. Wong; Wei Wang; Katherine L. Wright; Timothy F. Lane; Eldad Zacksenhaus; Sean E. Egan
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Coactivation of AKT and β-Catenin in Mice Rapidly Induces Formation of Lipogenic Liver Tumors
Jimmy K. Stauffer; Anthony J. Scarzello; Jesper B. Andersen; Rachel L. De Kluyver; Timothy C. Back; Jonathan M. Weiss; Snorri S. Thorgeirsson; Robert H. Wiltrout
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Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
Dulcie Lai; King Ching Ho; Yawei Hao; Xiaolong Yang
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The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling
Laura E. Lamb; Jelani C. Zarif; Cindy K. Miranti
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PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
Kim H.T. Paraiso; Yun Xiang; Vito W. Rebecca; Ethan V. Abel; Y. Ann Chen; A. Cecilia Munko; Elizabeth Wood; Inna V. Fedorenko; Vernon K. Sondak; Alexander R.A. Anderson; Antoni Ribas; Maurizia Dalla Palma; Katherine L. Nathanson; John M. Koomen; Jane L. Messina; Keiran S.M. Smalley
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Repression of Vascular Endothelial Growth Factor Expression by the Runt-Related Transcription Factor 1 in Acute Myeloid Leukemia
Arja ter Elst; Bin Ma; Frank J.G. Scherpen; Hendrik J.M. de Jonge; Jenny Douwes; Albertus T.J. Wierenga; Jan Jacob Schuringa; Willem A. Kamps; Eveline S.J.M. de Bont
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Role of Heparanase in Radiation-Enhanced Invasiveness of Pancreatic Carcinoma
Amichay Meirovitz; Esther Hermano; Immanuel Lerner; Eyal Zcharia; Claudio Pisano; Tamar Peretz; Michael Elkin
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p53 Binds to and Is Required for the Repression of Arf Tumor Suppressor by HDAC and Polycomb
Yaxue Zeng; Yojiro Kotake; Xin-Hai Pei; Matthew D. Smith; Yue Xiong
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Letters to the Editor

Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity—Letter
Ting-Chao Chou
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Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity—Response
J. Jack Lee; Maiying Kong
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Rebuttal to the Response of Lee and Kong
Ting-Chao Chou
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Rebuttal to the Response of Chou
J. Jack Lee; Maiying Kong
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Obituary

Gary D. Kruh: In Memoriam (1951–2011)
Kenneth D. Tew
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Corrections

Correction: Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination–Defective Cells
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Correction: MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor–Dependent Fashion to Suppress Carcinoma Growth
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Correction: PML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia
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Correction: Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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