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15 January 2011
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Breast cancer stem cells are regulated by mesenchymal stem cells via cytokine networks. Breast cancer cells secrete IL6, which recruits bone marrow–derived mesenchymal stem cells and induces CXCL7 secretion by these cells. CXCL7 in turn induces the production of multiple cytokines including IL8 and IL6, which completes a positive feedback loop and stimulates the self-renewal of breast cancer stem cells driving tumor growth and metastasis. For details, see the article by Liu and colleagues on page 614 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Perspective
Meeting Reports
Microenvironment and Immunology
Heat Shock Protein 27 Differentiates Tolerogenic Macrophages That May Support Human Breast Cancer Progression
Sanjib Banerjee; Chuen-Fu L. Lin; Kristin A. Skinner; Linda M. Schiffhauer; James Peacock; David G. Hicks; Eileen M. Redmond; David Morrow; Alissa Huston; Michelle Shayne; Howard N. Langstein; Carol L. Miller-Graziano; Jennifer Strickland; Lauren O'Donoghue; Asit K. De
Molecular and Cellular Pathobiology
A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF
Nunzio Iraci; Daniel Diolaiti; Antonella Papa; Antonio Porro; Emanuele Valli; Samuele Gherardi; Steffi Herold; Martin Eilers; Roberto Bernardoni; Giuliano Della Valle; Giovanni Perini
Prevention and Epidemiology
A Randomized Clinical Trial of the Effects of Supplemental Calcium and Vitamin D3 on Markers of Their Metabolism in Normal Mucosa of Colorectal Adenoma Patients
Thomas U. Ahearn; Marjorie L. McCullough; W. Dana Flanders; Qi Long; Eduard Sidelnikov; Veronika Fedirko; Carrie R. Daniel; Robin E. Rutherford; Aasma Shaukat; Roberd M. Bostick
Therapeutics, Targets, and Chemical Biology
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
Gerrit J. P. Dijkgraaf; Bruno Alicke; Lasse Weinmann; Thomas Januario; Kristina West; Zora Modrusan; Dan Burdick; Richard Goldsmith; Kirk Robarge; Dan Sutherlin; Suzie J. Scales; Stephen E. Gould; Robert L. Yauch; Frederic J. de Sauvage
Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model
Steven A. Belinsky; Marcie J. Grimes; Maria A. Picchi; Hugh D. Mitchell; Chris A. Stidley; Yohannes Tesfaigzi; Meghan M. Channell; Yanbin Liu; Robert A. Casero, Jr.; Stephen B. Baylin; Mathew D. Reed; Carmen S. Tellez; Thomas H. March
A Novel Sialyltransferase Inhibitor Suppresses FAK/Paxillin Signaling and Cancer Angiogenesis and Metastasis Pathways
Jia-Yang Chen; Yen-An Tang; Sin-Ming Huang; Hsueh-Fen Juan; Li-Wha Wu; Ying-Chieh Sun; Szu-Chi Wang; Kuan-Wei Wu; Gopula Balraj; Tzu-Ting Chang; Wen-Shan Li; Hung-Chi Cheng; Yi-Ching Wang
Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy
Anne-Laure Rérole; Jessica Gobbo; Aurelie De Thonel; Elise Schmitt; Jean Paul Pais de Barros; Arlette Hammann; David Lanneau; Eric Fourmaux; Oleg Deminov; Olivier Micheau; Laurent Lagrost; Pierre Colas; Guido Kroemer; Carmen Garrido
Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions
Murray J. Towle; Kathleen A. Salvato; Bruce F. Wels; Kimberley K. Aalfs; Wanjun Zheng; Boris M. Seletsky; Xiaojie Zhu; Bryan M. Lewis; Yoshito Kishi; Melvin J. Yu; Bruce A. Littlefield
Highly Specific Auto-Antibodies against Claudin-18 Isoform 2 Induced by a Chimeric HBcAg Virus-Like Particle Vaccine Kill Tumor Cells and Inhibit the Growth of Lung Metastases
Thorsten Klamp; Jens Schumacher; Georg Huber; Christoph Kühne; Ulrich Meissner; Abderraouf Selmi; Thomas Hiller; Sebastian Kreiter; Jürgen Markl; Özlem Türeci; Ugur Sahin
Tumor and Stem Cell Biology
Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer
Lyndsay V. Rhodes; Sarah P. Short; Nicole F. Neel; Virgilio A. Salvo; Yun Zhu; Steven Elliott; Yongkun Wei; Dihua Yu; Menghong Sun; Shannon E. Muir; Juan P. Fonseca; Melyssa R. Bratton; Chris Segar; Syreeta L. Tilghman; Tammy Sobolik-Delmaire; Linda W. Horton; Snjezana Zaja-Milatovic; Bridgette M. Collins-Burow; Scott Wadsworth; Barbara S. Beckman; Charles E. Wood; Suzanne A. Fuqua; Kenneth P. Nephew; Paul Dent; Rebecca A. Worthylake; Tyler J. Curiel; Mien-Chie Hung; Ann Richmond; Matthew E. Burow
Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
Suling Liu; Christophe Ginestier; Sing J. Ou; Shawn G. Clouthier; Shivani H. Patel; Florence Monville; Hasan Korkaya; Amber Heath; Julie Dutcher; Celina G. Kleer; Younghun Jung; Gabriela Dontu; Russell Taichman; Max S. Wicha
Letter to the Editor
Correction
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