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Volume 71, Issue 2
15 January 2011
Cancer Research Cover Image for Volume 71, Issue 2
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  • Cover Image

    Cover Image

    Issue cover image
    Breast cancer stem cells are regulated by mesenchymal stem cells via cytokine networks. Breast cancer cells secrete IL6, which recruits bone marrow–derived mesenchymal stem cells and induces CXCL7 secretion by these cells. CXCL7 in turn induces the production of multiple cytokines including IL8 and IL6, which completes a positive feedback loop and stimulates the self-renewal of breast cancer stem cells driving tumor growth and metastasis. For details, see the article by Liu and colleagues on page 614 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
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Reviews

Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy
Dong Woo Kang; Kang-Yell Choi; Do Sik Min
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Physical Oncology: A Bench-to-Bedside Quantitative and Predictive Approach
Hermann B. Frieboes; Mark A.J. Chaplain; Alastair M. Thompson; Elaine L. Bearer; John S. Lowengrub; Vittorio Cristini
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Perspective

Cancer Cells Cut Homophilic Cell Adhesion Molecules and Run
Sonya E.L. Craig; Susann M. Brady-Kalnay
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Meeting Reports

The First Tianjin, China Forum on Tumor Microenvironment
Evan T. Keller; Lu-Yuan Li
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NCI Image-Guided Drug Delivery Summit
Pushpa Tandon; Keyvan Farahani
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Microenvironment and Immunology

Heat Shock Protein 27 Differentiates Tolerogenic Macrophages That May Support Human Breast Cancer Progression
Sanjib Banerjee; Chuen-Fu L. Lin; Kristin A. Skinner; Linda M. Schiffhauer; James Peacock; David G. Hicks; Eileen M. Redmond; David Morrow; Alissa Huston; Michelle Shayne; Howard N. Langstein; Carol L. Miller-Graziano; Jennifer Strickland; Lauren O'Donoghue; Asit K. De
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Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway
Audrey Le Floc'h; Abdelali Jalil; Katarzyna Franciszkiewicz; Pierre Validire; Isabelle Vergnon; Fathia Mami-Chouaib
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Molecular and Cellular Pathobiology

A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23)
Naoki Morito; Keigyou Yoh; Atsuko Maeda; Takako Nakano; Akiko Fujita; Manabu Kusakabe; Michito Hamada; Takashi Kudo; Kunihiro Yamagata; Satoru Takahashi
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HMGA2 Overexpression-Induced Ovarian Surface Epithelial Transformation Is Mediated Through Regulation of EMT Genes
Jingjing Wu; Zhaojian Liu; Changshun Shao; Yaoqin Gong; Eva Hernando; Peng Lee; Masashi Narita; William Muller; Jinsong Liu; Jian-Jun Wei
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p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase
Hong-Gang Yu; Ju-Ock Nam; Nichol L. G. Miller; Isabelle Tanjoni; Colin Walsh; Lei Shi; Linda Kim; Xiao Lei Chen; Alok Tomar; Ssang-Taek Lim; David D. Schlaepfer
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The Tumor Suppressor Protein Menin Inhibits AKT Activation by Regulating Its Cellular Localization
Yan Wang; Atsushi Ozawa; Shadia Zaman; Nijaguna B. Prasad; Settara C. Chandrasekharappa; Sunita K. Agarwal; Stephen J. Marx
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Amiloride Modulates Alternative Splicing in Leukemic Cells and Resensitizes Bcr-AblT315I Mutant Cells to Imatinib
Wen-Hsin Chang; Ta-Chih Liu; Wen-Kuang Yang; Chien-Chih Lee; Yi-Hsiung Lin; Tsai-Yun Chen; Jan-Gowth Chang
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Phosphorylation of H2AX at Ser139 and a New Phosphorylation Site Ser16 by RSK2 Decreases H2AX Ubiquitination and Inhibits Cell Transformation
Feng Zhu; Tatyana A. Zykova; Cong Peng; Jishuai Zhang; Yong-Yeon Cho; Duo Zheng; Ke Yao; Wei-Ya Ma; Andy T. Y. Lau; Ann M. Bode; Zigang Dong
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A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF
Nunzio Iraci; Daniel Diolaiti; Antonella Papa; Antonio Porro; Emanuele Valli; Samuele Gherardi; Steffi Herold; Martin Eilers; Roberto Bernardoni; Giuliano Della Valle; Giovanni Perini
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Prevention and Epidemiology

A Randomized Clinical Trial of the Effects of Supplemental Calcium and Vitamin D3 on Markers of Their Metabolism in Normal Mucosa of Colorectal Adenoma Patients
Thomas U. Ahearn; Marjorie L. McCullough; W. Dana Flanders; Qi Long; Eduard Sidelnikov; Veronika Fedirko; Carrie R. Daniel; Robin E. Rutherford; Aasma Shaukat; Roberd M. Bostick
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Therapeutics, Targets, and Chemical Biology

IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer
Chi-Wen Lo; Min-Wei Chen; Michael Hsiao; Shiuan Wang; Chi-An Chen; Sheng-Mou Hsiao; Jeng-Shou Chang; Tsung-Ching Lai; Stefan Rose-John; Min-Liang Kuo; Lin-Hung Wei
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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
Gerrit J. P. Dijkgraaf; Bruno Alicke; Lasse Weinmann; Thomas Januario; Kristina West; Zora Modrusan; Dan Burdick; Richard Goldsmith; Kirk Robarge; Dan Sutherlin; Suzie J. Scales; Stephen E. Gould; Robert L. Yauch; Frederic J. de Sauvage
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MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for KRAS Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy
Juyong Yoon; Kyoung-Hwa Koo; Kang-Yell Choi
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Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model
Steven A. Belinsky; Marcie J. Grimes; Maria A. Picchi; Hugh D. Mitchell; Chris A. Stidley; Yohannes Tesfaigzi; Meghan M. Channell; Yanbin Liu; Robert A. Casero, Jr.; Stephen B. Baylin; Mathew D. Reed; Carmen S. Tellez; Thomas H. March
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CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors
Victoria E. Anderson; Michael I. Walton; Paul D. Eve; Katherine J. Boxall; Laurent Antoni; John J. Caldwell; Wynne Aherne; Laurence H. Pearl; Antony W. Oliver; Ian Collins; Michelle D. Garrett
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A Novel Sialyltransferase Inhibitor Suppresses FAK/Paxillin Signaling and Cancer Angiogenesis and Metastasis Pathways
Jia-Yang Chen; Yen-An Tang; Sin-Ming Huang; Hsueh-Fen Juan; Li-Wha Wu; Ying-Chieh Sun; Szu-Chi Wang; Kuan-Wei Wu; Gopula Balraj; Tzu-Ting Chang; Wen-Shan Li; Hung-Chi Cheng; Yi-Ching Wang
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Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy
Anne-Laure Rérole; Jessica Gobbo; Aurelie De Thonel; Elise Schmitt; Jean Paul Pais de Barros; Arlette Hammann; David Lanneau; Eric Fourmaux; Oleg Deminov; Olivier Micheau; Laurent Lagrost; Pierre Colas; Guido Kroemer; Carmen Garrido
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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions
Murray J. Towle; Kathleen A. Salvato; Bruce F. Wels; Kimberley K. Aalfs; Wanjun Zheng; Boris M. Seletsky; Xiaojie Zhu; Bryan M. Lewis; Yoshito Kishi; Melvin J. Yu; Bruce A. Littlefield
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The BH3 Mimetic ABT-737 Induces Cancer Cell Senescence
Jin H. Song; Karthikeyan Kandasamy; Marina Zemskova; Ying-Wei Lin; Andrew S. Kraft
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Highly Specific Auto-Antibodies against Claudin-18 Isoform 2 Induced by a Chimeric HBcAg Virus-Like Particle Vaccine Kill Tumor Cells and Inhibit the Growth of Lung Metastases
Thorsten Klamp; Jens Schumacher; Georg Huber; Christoph Kühne; Ulrich Meissner; Abderraouf Selmi; Thomas Hiller; Sebastian Kreiter; Jürgen Markl; Özlem Türeci; Ugur Sahin
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CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells
Daniel E. Frigo; Matthew K. Howe; Bryan M. Wittmann; Abigail M. Brunner; Ian Cushman; Qianben Wang; Myles Brown; Anthony R. Means; Donald P. McDonnell
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ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins
Sahdeo Prasad; Vivek R. Yadav; Jayaraj Ravindran; Bharat B. Aggarwal
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Tumor and Stem Cell Biology

Microfluidic-Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in the Sera of Prostate Cancer Patients
Felix Moltzahn; Adam B. Olshen; Lauren Baehner; Andrew Peek; Lawrence Fong; Hubert Stöppler; Jeffry Simko; Joan F. Hilton; Peter Carroll; Robert Blelloch
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Chromosome Breakage Is Regulated by the Interaction of the BLM Helicase and Topoisomerase IIα
Beatriz Russell; Saumitri Bhattacharyya; Jeremy Keirsey; April Sandy; Patrick Grierson; Erin Perchiniak; Juraj Kavecansky; Samir Acharya; Joanna Groden
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Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer
Myles C. Hodgson; Long-jiang Shao; Anna Frolov; Rile Li; Leif E. Peterson; Gustavo Ayala; Michael M. Ittmann; Nancy L. Weigel; Irina U. Agoulnik
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MicroRNA-616 Induces Androgen-Independent Growth of Prostate Cancer Cells by Suppressing Expression of Tissue Factor Pathway Inhibitor TFPI-2
Stephanie Ma; Yuen Piu Chan; Pak Shing Kwan; Terence K. Lee; Mingxia Yan; Kwan Ho Tang; Ming Tat Ling; Juergen R. Vielkind; Xin-Yuan Guan; Kwok Wah Chan
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Suppression of Colonic Polyposis by Homeoprotein CDX2 through its Nontranscriptional Function that Stabilizes p27Kip1
Koji Aoki; Fumihiko Kakizaki; Hiromi Sakashita; Toshiaki Manabe; Masahiro Aoki; Makoto M. Taketo
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Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer
Lyndsay V. Rhodes; Sarah P. Short; Nicole F. Neel; Virgilio A. Salvo; Yun Zhu; Steven Elliott; Yongkun Wei; Dihua Yu; Menghong Sun; Shannon E. Muir; Juan P. Fonseca; Melyssa R. Bratton; Chris Segar; Syreeta L. Tilghman; Tammy Sobolik-Delmaire; Linda W. Horton; Snjezana Zaja-Milatovic; Bridgette M. Collins-Burow; Scott Wadsworth; Barbara S. Beckman; Charles E. Wood; Suzanne A. Fuqua; Kenneth P. Nephew; Paul Dent; Rebecca A. Worthylake; Tyler J. Curiel; Mien-Chie Hung; Ann Richmond; Matthew E. Burow
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Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
Suling Liu; Christophe Ginestier; Sing J. Ou; Shawn G. Clouthier; Shivani H. Patel; Florence Monville; Hasan Korkaya; Amber Heath; Julie Dutcher; Celina G. Kleer; Younghun Jung; Gabriela Dontu; Russell Taichman; Max S. Wicha
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Letter to the Editor

Statistical Design Considerations in Animal Studies Published Recently in Cancer Research
Kenneth R. Hess
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Correction

Correction: Surface-Immobilized Aptamers for Cancer Cell Isolation and Microscopic Cytology
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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