Skip to Main Content

Advertisement

American Association for Cancer Research Logo
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 71, Issue 17
1 September 2011
Cancer Research Cover Image for Volume 71, Issue 17
All Issues
  • Cover Image

    Cover Image

    issue cover
    Human U-87 MG glioma tumor cells expressing green fluorescent protein were xenografted orthotopically into an athymic nude mouse brain. The mouse brain was cryo-imaged and reconstructed in 3 dimensions to show the human U-87 MG glioma main tumor mass (pseudocolored green), dispersed tumor cells (pseudocolored yellow), and the mouse brain vasculature (pseudocolored red). Cells from the U-87 MG glioma tumor (yellow cells) migrated and dispersed on a nearby blood vessel. For details, see the article by Burden-Gulley and colleagues on page 5932 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Reviews

Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
Wolf Herman Fridman; Jérôme Galon; Franck Pagès; Eric Tartour; Catheriné Sautès-Fridman; Guido Kroemer
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
TGF-β/SMAD/GLI2 Signaling Axis in Cancer Progression and Metastasis
Delphine Javelaud; Vasileia I. Alexaki; Sylviane Dennler; Khalid S. Mohammad; Theresa A. Guise; Alain Mauviel
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Meeting Reports

Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo
Robin S Dothager; David Piwnica-Worms
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
The First AACR Special Conference on Stem Cells, Development, and Cancer: Some of These Cells Are Not Like the Others
David G. Kent; Jennifer C. Lin; Geraldine Aubert
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Priority Report

HERC2 Interacts with Claspin and Regulates DNA Origin Firing and Replication Fork Progression
Naoki Izawa; Wenwen Wu; Ko Sato; Hiroyuki Nishikawa; Akihiro Kato; Narikazu Boku; Fumio Itoh; Tomohiko Ohta
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Clinical Studies

Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas
Shivaani Kummar; Alice Chen; Jiuping Ji; Yiping Zhang; Joel M. Reid; Matthew Ames; Lee Jia; Marcie Weil; Giovanna Speranza; Anthony J. Murgo; Robert Kinders; Lihua Wang; Ralph E. Parchment; John Carter; Howard Stotler; Larry Rubinstein; Melinda Hollingshead; Giovanni Melillo; Yves Pommier; William Bonner; Joseph E. Tomaszewski; James H. Doroshow
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Integrated Systems and Technologies

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer
Francesca M. Buffa; Carme Camps; Laura Winchester; Cameron E. Snell; Harriet E. Gee; Helen Sheldon; Marian Taylor; Adrian L. Harris; Jiannis Ragoussis
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Genome-wide Profiling of Chromatin Signatures Reveals Epigenetic Regulation of MicroRNA Genes in Colorectal Cancer
Hiromu Suzuki; Shintaro Takatsuka; Hirofumi Akashi; Eiichiro Yamamoto; Masanori Nojima; Reo Maruyama; Masahiro Kai; Hiro-o Yamano; Yasushi Sasaki; Takashi Tokino; Yasuhisa Shinomura; Kohzoh Imai; Minoru Toyota
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma
Stacy Ugras; Elliott Brill; Anders Jacobsen; Markus Hafner; Nicholas D. Socci; Penelope L. DeCarolis; Raya Khanin; Rachael O'Connor; Aleksandra Mihailovic; Barry S. Taylor; Robert Sheridan; Jeffrey M. Gimble; Agnes Viale; Aimee Crago; Cristina R. Antonescu; Chris Sander; Thomas Tuschl; Samuel Singer
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Microenvironment and Immunology

Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
Niels Halama; Sara Michel; Matthias Kloor; Inka Zoernig; Axel Benner; Anna Spille; Thora Pommerencke; Doeberitz Magnus von Knebel; Gunnar Folprecht; Birgit Luber; Nadine Feyen; Uwe M. Martens; Philipp Beckhove; Sacha Gnjatic; Peter Schirmacher; Esther Herpel; Juergen Weitz; Niels Grabe; Dirk Jaeger
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer
Ludovic Martinet; Ignacio Garrido; Thomas Filleron; Sophie Le Guellec; Elisabeth Bellard; Jean-Jacques Fournie; Philippe Rochaix; Jean-Philippe Girard
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model
Debbie Liao; Ze Liu; Wolfgang J. Wrasidlo; Yunping Luo; Giang Nguyen; Tingmei Chen; Rong Xiang; Ralph A. Reisfeld
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
Markus Chmielewski; Caroline Kopecky; Andreas A. Hombach; Hinrich Abken
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
CXCR3 Enhances a T-Cell–Dependent Epidermal Proliferative Response and Promotes Skin Tumorigenesis
Ashley E. Winkler; Joshua J. Brotman; Meredith E. Pittman; Nancy P. Judd; James S. Lewis, Jr; Robert D. Schreiber; Ravindra Uppaluri
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Molecular and Cellular Pathobiology

Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis
Ernesta Fagiani; Pascal Lorentz; Lucie Kopfstein; Gerhard Christofori
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Dual Function of ERRα in Breast Cancer and Bone Metastasis Formation: Implication of VEGF and Osteoprotegerin
Anaïs Fradet; Helène Sorel; Lamia Bouazza; Delphine Goehrig; Baptiste Dépalle; Akeila Bellahcène; Vincent Castronovo; Hélène Follet; Françoise Descotes; Jane E. Aubin; Philippe Clézardin; Edith Bonnelye
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
Tanja Prenzel; Yvonne Begus-Nahrmann; Frank Kramer; Magali Hennion; Chieh Hsu; Theresa Gorsler; Corinna Hintermair; Dirk Eick; Elisabeth Kremmer; Mikael Simons; Tim Beissbarth; Steven A. Johnsen
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Insulin Increases De Novo Steroidogenesis in Prostate Cancer Cells
Amy A. Lubik; Jennifer H. Gunter; Stephen C. Hendy; Jennifer A. Locke; Hans H. Adomat; Vanessa Thompson; Adrian Herington; Martin E. Gleave; Michael Pollak; Colleen C. Nelson
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
The Tumor Suppressive MicroRNA miR-218 Targets the mTOR Component Rictor and Inhibits AKT Phosphorylation in Oral Cancer
Atsushi Uesugi; Ken-ichi Kozaki; Tomohiko Tsuruta; Mayuko Furuta; Kei-ichi Morita; Issei Imoto; Ken Omura; Johji Inazawa
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Identification of Fat4 and Tsc22d1 as Novel Candidate Genes for Spontaneous Pulmonary Adenomas
Annerose Berndt; Clinton L. Cario; Kathleen A. Silva; Victoria E. Kennedy; David E. Harrison; Beverly Paigen; John P. Sundberg
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Prevention and Epidemiology

Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes
Timothy R. Rebbeck; Nandita Mitra; Susan M. Domchek; Fei Wan; Tara M. Friebel; Teo V. Tran; Christian F. Singer; Muy-Kheng Maria Tea; Joanne L. Blum; Nadine Tung; Olufunmilayo I. Olopade; Jeffrey N. Weitzel; Henry T. Lynch; Carrie L. Snyder; Judy E. Garber; Antonis C. Antoniou; Susan Peock; D. Gareth Evans; Joan Paterson; M. John Kennedy; Alan Donaldson; Huw Dorkins; Douglas F. Easton; for the Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE); Wendy S. Rubinstein; Mary B. Daly; Claudine Isaacs; Heli Nevanlinna; Fergus J. Couch; Irene L. Andrulis; Eitan Freidman; Yael Laitman; Patricia A. Ganz; Gail E. Tomlinson; Susan L. Neuhausen; Steven A. Narod; Catherine M. Phelan; Roger Greenberg; Katherine L. Nathanson
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Therapeutics, Targets, and Chemical Biology

Modulating Microtubule Stability Enhances the Cytotoxic Response of Cancer Cells to Paclitaxel
Ahmed Ashour Ahmed; Xiaoyan Wang; Zhen Lu; Juliet Goldsmith; Xiao-Feng Le; Geoffrey Grandjean; Geoffrey Bartholomeusz; Bradley Broom; Robert C. Bast, Jr
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells
Carol Babij; Yihong Zhang; Robert J. Kurzeja; Anke Munzli; Amro Shehabeldin; Manory Fernando; Kim Quon; Paul D. Kassner; Astrid A. Ruefli-Brasse; Vivienne J. Watson; Flordeliza Fajardo; Angela Jackson; James Zondlo; Yu Sun; Aaron R. Ellison; Cherylene A. Plewa; Miguel Tisha San; John Robinson; John McCarter; Ralf Schwandner; Ted Judd; Josette Carnahan; Isabelle Dussault
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Potent Antitumor Immunity Generated by a CD40-Targeted Adenoviral Vaccine
Basav N. Hangalapura; Dinja Oosterhoff; Jan de Groot; Louis Boon; Thomas Tüting; Alfons J. van den Eertwegh; Winald R. Gerritsen; Victor W. van Beusechem; Alexander Pereboev; David T. Curiel; Rik J. Scheper; Tanja D. de Gruijl
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer
Francois Lamoureux; Christian Thomas; Min-Jean Yin; Hidetoshi Kuruma; Eliana Beraldi; Ladan Fazli; Amina Zoubeidi; Martin E. Gleave
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Bcl-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Chemotherapeutic Response
Justin R. Pritchard; Luke A. Gilbert; Corbin E. Meacham; Jennifer L. Ricks; Hai Jiang; Douglas A. Lauffenburger; Michael T. Hemann
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Overexpression of MBD2 in Glioblastoma Maintains Epigenetic Silencing and Inhibits the Antiangiogenic Function of the Tumor Suppressor Gene BAI1
Dan Zhu; Stephen B. Hunter; Paula M. Vertino; Erwin G. Van Meir
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes
David B. Lovejoy; Patric J. Jansson; Ulf T. Brunk; Jacky Wong; Prem Ponka; Des R. Richardson
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Chromogranin A Restricts Drug Penetration and Limits the Ability of NGR-TNF to Enhance Chemotherapeutic Efficacy
Eleonora Dondossola; Anna Maria Gasparri; Barbara Colombo; Angelina Sacchi; Flavio Curnis; Angelo Corti
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Definition of the Landscape of Promoter DNA Hypomethylation in Liver Cancer
Barbara Stefanska; Jian Huang; Bishnu Bhattacharyya; Matthew Suderman; Michael Hallett; Ze-Guang Han; Moshe Szyf
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
Tapati Mazumdar; Jennifer DeVecchio; Akwasi Agyeman; Ting Shi; Janet A. Houghton
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Cytotoxic Activity of Immunotoxin SS1P Is Modulated by TACE-Dependent Mesothelin Shedding
Yujian Zhang; Oleg Chertov; Jingli Zhang; Raffit Hassan; Ira Pastan
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer
Kasper Toustrup; Brita Singers Sørensen; Marianne Nordsmark; Morten Busk; Carsten Wiuf; Jan Alsner; Jens Overgaard
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Tumor and Stem Cell Biology

Novel Cryo-Imaging of the Glioma Tumor Microenvironment Reveals Migration and Dispersal Pathways in Vivid Three-Dimensional Detail
Susan M. Burden-Gulley; Mohammed Q. Qutaish; Kristin E. Sullivant; Hong Lu; Jing Wang; Sonya E.L. Craig; James P. Basilion; David L. Wilson; Susann M. Brady-Kalnay
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Corrections

Correction: Interaction between FGFR-2, STAT5, and Progesterone Receptors in Breast Cancer
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Correction: TGFβ/TNFα-Mediated Epithelial–Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

Advertisement

Email alerts

eTOC Alert
Close Modal
Latest News
“A Game-Changer” HER2 TKI for NSCLC
Using Liquid Biopsy to Guide Adjuvant ICI for dMMR Tumors
Machine Learning Could Boost Skin Cancer Detection in Areas with Few Resources
View more recent articles
Breaking
Cell Atlas Examines Circadian Rhythm in TME
Pembrolizumab Boosts EFS in Head and Neck Cancer
Penpulimab OK’d for Nasopharyngeal Carcinoma
View more recent articles
Research Watch
ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response
Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR
Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck.  None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept