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Volume 71, Issue 16

15 August 2011

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The Y-box binding protein (YB-1) is an oncogenic transcription factor known for its ability to cause drug resistance and cancer recurrence. Fotovati and colleagues report that YB-1 supports brain tumor-initiating cells by inhibiting differentiation through the maintenance of proteins associated with stem cells. In cancer-derived neurospheres grown from pediatric glioblastoma multiforme cells, YB-1 was highly expressed along with the stem cell markers nestin and Bmi-1. For details, see the article by Fotovati and colleagues on page 5569 of this issue.
Table of Contents

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Breaking Advances
Reviews
Priority Reports
Integrated Systems and Technologies
Microenvironment and Immunology
Molecular and Cellular Pathobiology
Therapeutics, Targets, and Chemical Biology
Tumor and Stem Cell Biology

Cancer Research

Breaking Advances

Highlights from Recent Cancer Literature

Extract

View articletitled, Highlights from Recent Cancer Literature

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Reviews

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

Francesca Aguilo; Ming-Ming Zhou; Martin J. Walsh

Abstract

View articletitled, Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

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B-Myb, Cancer, Senescence, and MicroRNAs

Ivan Martinez; Daniel DiMaio

Abstract

View articletitled, B-Myb, Cancer, Senescence, and MicroRNAs

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Priority Reports

Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

Shanté P. Williams; Michal O. Nowicki; Fang Liu; Rachael Press; Jakub Godlewski; Mahmoud Abdel-Rasoul; Balveen Kaur; Soledad A. Fernandez; E. Antonio Chiocca; Sean E. Lawler

Abstracts

View articletitled, Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

Supplementary data

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Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal ABL1 Allele

Anna Virgili; Mateusz Koptyra; Yashodhara Dasgupta; Eliza Glodkowska-Mrowka; Tomasz Stoklosa; Elisabeth P. Nacheva; Tomasz Skorski

Abstracts

View articletitled, Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal ABL1 Allele

Supplementary data

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TMPRSS2–ERG-Mediated Feed-Forward Regulation of Wild-Type ERG in Human Prostate Cancers

Ram-Shankar Mani; Matthew K. Iyer; Qi Cao; J. Chad Brenner; Lei Wang; Aparna Ghosh; Xuhong Cao; Robert J. Lonigro; Scott A. Tomlins; Sooryanarayana Varambally; Arul M. Chinnaiyan

Abstracts

View articletitled, TMPRSS2–ERG-Mediated Feed-Forward Regulation of Wild-Type ERG in Human Prostate Cancers

Supplementary data

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IL-18 Induces PD-1–Dependent Immunosuppression in Cancer

Magali Terme; Evelyn Ullrich; Laetitia Aymeric; Kathrin Meinhardt; Mélanie Desbois; Nicolas Delahaye; Sophie Viaud; Bernard Ryffel; Hideo Yagita; Gilles Kaplanski; Armelle Prévost-Blondel; Masashi Kato; Joachim L. Schultze; Eric Tartour; Guido Kroemer; Nathalie Chaput; Laurence Zitvogel

Abstracts

View articletitled, IL-18 Induces PD-1–Dependent Immunosuppression in Cancer

Supplementary data

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Integrated Systems and Technologies

Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models

Julio Saez-Rodriguez; Leonidas G. Alexopoulos; MingSheng Zhang; Melody K. Morris; Douglas A. Lauffenburger; Peter K. Sorger

Abstracts

View articletitled, Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models

Supplementary data

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Microenvironment and Immunology

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

Sophia Platonova; Julien Cherfils-Vicini; Diane Damotte; Lucile Crozet; Vincent Vieillard; Pierre Validire; Pascale André; Marie-Caroline Dieu-Nosjean; Marco Alifano; Jean-François Régnard; Wolf-Herman Fridman; Catherine Sautès-Fridman; Isabelle Cremer

Abstracts

View articletitled, Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

Supplementary data

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Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

Sana Intidhar Labidi-Galy; Vanja Sisirak; Pierre Meeus; Michael Gobert; Isabelle Treilleux; Agathe Bajard; Jean-Damien Combes; Julien Faget; François Mithieux; Alexandre Cassignol; Olivier Tredan; Isabelle Durand; Christine Ménétrier-Caux; Christophe Caux; Jean-Yves Blay; Isabelle Ray-Coquard; Nathalie Bendriss-Vermare

Abstracts

View articletitled, Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

Supplementary data

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A Novel Tumor Antigen Derived from Enhanced Degradation of Bax Protein in Human Cancers

Cláudia Trindade Nunes; Kelly L. Miners; Garry Dolton; Chris Pepper; Chris Fegan; Malcolm D. Mason; Stephen Man

Abstracts

View articletitled, A Novel Tumor Antigen Derived from Enhanced Degradation of Bax Protein in Human Cancers

Supplementary data

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The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti–CTLA-4 Therapy

Tihui Fu; Qiuming He; Padmanee Sharma

Abstracts

View articletitled, The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti–CTLA-4 Therapy

Supplementary data

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Maximal T Cell–Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4⁺ and CD8⁺ T Cells

Alicia González-Martín; Lucio Gómez; Joseph Lustgarten; Emilia Mira; Santos Mañes

Abstracts

View articletitled, Maximal T Cell–Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells

Supplementary data

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TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity

Dusan Bogunovic; Olivier Manches; Emmanuelle Godefroy; Alice Yewdall; Anne Gallois; Andres M. Salazar; Isabelle Marie; David E. Levy; Nina Bhardwaj

Abstracts

View articletitled, TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity

Supplementary data

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Molecular and Cellular Pathobiology

Comparison of Increased Aromatase versus ERα in the Generation of Mammary Hyperplasia and Cancer

Edgar S. Díaz-Cruz; Yasuro Sugimoto; G. Ian Gallicano; Robert W. Brueggemeier; Priscilla A. Furth

Abstracts

View articletitled, Comparison of Increased Aromatase versus ERα in the Generation of Mammary Hyperplasia and Cancer

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Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma

Yuan Li; Peng Qu; Lingyan Wu; Beilin Li; Hong Du; Cong Yan

Abstracts

View articletitled, Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma

Supplementary data

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VHL Gene Mutations and Their Effects on Hypoxia Inducible Factor HIFα: Identification of Potential Driver and Passenger Mutations

Markus P. Rechsteiner; Adriana von Teichman; Anna Nowicka; Tullio Sulser; Peter Schraml; Holger Moch

Abstracts

View articletitled, VHL Gene Mutations and Their Effects on Hypoxia Inducible Factor HIFα: Identification of Potential Driver and Passenger Mutations

Supplementary data

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Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

Fei Yang; Ximing Tang; Erick Riquelme; Carmen Behrens; Monique B. Nilsson; Uma Giri; Marileila Varella-Garcia; Lauren A. Byers; Heather Y. Lin; Jing Wang; Maria G. Raso; Luc Girard; Kevin Coombes; J. Jack Lee; Roy S. Herbst; John D. Minna; John V. Heymach; Ignacio I. Wistuba

Abstracts

View articletitled, Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy

Supplementary data

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Therapeutics, Targets, and Chemical Biology

CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

Elda Righi; Satoshi Kashiwagi; Jianping Yuan; Michael Santosuosso; Pierre Leblanc; Rachel Ingraham; Benjamin Forbes; Beth Edelblute; Brian Collette; Deyin Xing; Magdalena Kowalski; Maria Cristina Mingari; Fabrizio Vianello; Michael Birrer; Sandra Orsulic; Glenn Dranoff; Mark C. Poznansky

Abstracts

View articletitled, CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer

Supplementary data

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Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-RafV600E Mutation

Huisheng Wang; Sherif Daouti; Wen-hui Li; Yang Wen; Christine Rizzo; Brian Higgins; Kathryn Packman; Neal Rosen; John F. Boylan; David Heimbrook; Huifeng Niu

Abstracts

View articletitled, Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-RafV600E Mutation

Supplementary data

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p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage

Juhong Jiang; Eddy S. Yang; Guochun Jiang; Somaira Nowsheen; Hong Wang; Tong Wang; Yihan Wang; Dean Billheimer; A. Bapsi Chakravarthy; Melissa Brown; Bruce Haffty; Fen Xia

Abstracts

View articletitled, p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage

Supplementary data

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Tumor and Stem Cell Biology

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression

Liquan Yang; Guangchun Chen; Sonali Mohanty; Glynis Scott; Fabeha Fazal; Arshad Rahman; Shahinoor Begum; Richard O. Hynes; Lei Xu

Abstracts

View articletitled, GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression

Supplementary data

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YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Abbas Fotovati; Samah Abu-Ali; Pei-Shan Wang; Loic P. Deleyrolle; Cathy Lee; Joanna Triscott; James Y. Chen; Sonia Franciosi; Yasuhiro Nakamura; Yasuo Sugita; Takeshi Uchiumi; Michihiko Kuwano; Blair R. Leavitt; Sheila K. Singh; Alexa Jury; Chris Jones; Hiroaki Wakimoto; Brent A. Reynolds; Catherine J. Pallen; Sandra E. Dunn

Abstracts

View articletitled, YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Supplementary data

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Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4

Matthew A. Powers; Marta M. Fay; Rachel E. Factor; Alana L. Welm; Katharine S. Ullman

Abstracts

View articletitled, Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4

Supplementary data

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p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-κB

Renée F. Johnson; Ini-Isabée Witzel; Neil D. Perkins

Abstracts

View articletitled, p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-κB

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Journal Archive

Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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Cancer Research

Table of Contents

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Microenvironment and Immunology

Molecular and Cellular Pathobiology

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Tumor and Stem Cell Biology

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