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Volume 71, Issue 15
1 August 2011
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    The search for biomarkers of cancer has focused on the tumor cells themselves. Pitteri et al. using an unbiased and in depth proteomic analysis of plasma from a model of Her2/neu driven breast cancer have identified the signaling between the tumor cells and microenvironment as a primary source of biomarkers. Shown are tumor cells embedded within extensive extracellular collagen matrix stained with trichrome blue. For details, see the article by Pitteri and colleagues on page 5090 of this issue.
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Reviews

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
Ciara Metcalfe; Frederic J. de Sauvage
View articletitled, Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists
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Chemotherapeutic Resistance: Surviving Stressful Situations
Luke A. Gilbert; Michael T. Hemann
View articletitled, Chemotherapeutic Resistance: Surviving Stressful Situations
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Priority Reports

Combinatorial Treatments That Overcome PDGFRβ-Driven Resistance of Melanoma Cells to V600EB-RAF Inhibition
Hubing Shi; Xiangju Kong; Antoni Ribas; Roger S. Lo
View articletitled, Combinatorial Treatments That Overcome PDGFRβ-Driven Resistance of Melanoma Cells to <sup>V600E</sup>B-RAF Inhibition
Supplementary data
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Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines
Vinay Swaminathan; Karthikeyan Mythreye; E. Tim O'Brien; Andrew Berchuck; Gerard C. Blobe; Richard Superfine
View articletitled, Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines
Supplementary data
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Clinical Studies

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
Panagiotis A. Konstantinopoulos; Dimitrios Spentzos; Elena Fountzilas; Nancy Francoeur; Srisowmya Sanisetty; Alexandros P. Grammatikos; Jonathan L. Hecht; Stephen A. Cannistra
View articletitled, Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
Supplementary data
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Integrated Systems and Technologies

Tumor Microenvironment–Derived Proteins Dominate the Plasma Proteome Response during Breast Cancer Induction and Progression
Sharon J. Pitteri; Karen S. Kelly-Spratt; Kay E. Gurley; Jacob Kennedy; Tina Busald Buson; Alice Chin; Hong Wang; Qing Zhang; Chee-Hong Wong; Lewis A. Chodosh; Peter S. Nelson; Samir M. Hanash; Christopher J. Kemp
View articletitled, Tumor Microenvironment–Derived Proteins Dominate the Plasma Proteome Response during Breast Cancer Induction and Progression
Supplementary data
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Microenvironment and Immunology

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Bethany L. Mundy-Bosse; Gregory B. Lesinski; Alena C. Jaime-Ramirez; Kristen Benninger; Mahmood Khan; Periannan Kuppusamy; Kristan Guenterberg; Sri Vidya Kondadasula; Abhik Ray Chaudhury; Krista M. La Perle; Melanie Kreiner; Gregory Young; Denis C. Guttridge; William E. Carson, III
View articletitled, Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
Supplementary data
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PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation
Wieger J. Norde; Frans Maas; Willemijn Hobo; Alan Korman; Michael Quigley; Michel G.D. Kester; Konnie Hebeda; J.H. Frederik Falkenburg; Nicolaas Schaap; Theo M. de Witte; Robbert van der Voort; Harry Dolstra
View articletitled, PD-1/PD-L1 Interactions Contribute to Functional T-Cell Impairment in Patients Who Relapse with Cancer After Allogeneic Stem Cell Transplantation
Supplementary data
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Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance
Carole Bourquin; Christian Hotz; Daniel Noerenberg; Andreas Voelkl; Simon Heidegger; Laurin C. Roetzer; Bettina Storch; Nadja Sandholzer; Cornelia Wurzenberger; David Anz; Stefan Endres
View articletitled, Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance
Supplementary data
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Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy
Pascale Hubert; Adèle Heitzmann; Sophie Viel; André Nicolas; Xavier Sastre-Garau; Pablo Oppezzo; Otto Pritsch; Eduardo Osinaga; Sebastian Amigorena
View articletitled, Antibody-Dependent Cell Cytotoxicity Synapses Form in Mice during Tumor-Specific Antibody Immunotherapy
Supplementary data
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Molecular and Cellular Pathobiology

Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Dimitrios Iliopoulos; Asaf Rotem; Kevin Struhl
View articletitled, Inhibition of miR-193a Expression by Max and RXRα Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation
Supplementary data
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IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
Hemal H. Mehta; Qinglei Gao; Colette Galet; Vladislava Paharkova; Junxiang Wan; Jonathan Said; Joanne J. Sohn; Gregory Lawson; Pinchas Cohen; Laura J. Cobb; Kuk-Wha Lee
View articletitled, IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
Supplementary data
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18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
Nicolaos Palaskas; Steven M. Larson; Nikolaus Schultz; Evangelia Komisopoulou; Justin Wong; Dan Rohle; Carl Campos; Nicolas Yannuzzi; Joseph R. Osborne; Irina Linkov; Edward R. Kastenhuber; Richard Taschereau; Seema B. Plaisier; Chris Tran; Adriana Heguy; Hong Wu; Chris Sander; Michael E. Phelps; Cameron Brennan; Elisa Port; Jason T. Huse; Thomas G. Graeber; Ingo K. Mellinghoff
View articletitled, <sup>18</sup>F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
Supplementary data
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Prevention and Epidemiology

Genetic Variation in an miRNA-1827 Binding Site in MYCL1 Alters Susceptibility to Small-Cell Lung Cancer
Fang Xiong; Chen Wu; Jiang Chang; Dianke Yu; Binghe Xu; Peng Yuan; Kan Zhai; Jian Xu; Wen Tan; Dongxin Lin
View articletitled, Genetic Variation in an miRNA-1827 Binding Site in <em>MYCL1</em> Alters Susceptibility to Small-Cell Lung Cancer
Supplementary data
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Therapeutics, Targets, and Chemical Biology

Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis
Yong Gao; Zhiliang Jia; Xiangyu Kong; Qiang Li; David Z. Chang; Daoyan Wei; Xiangdong Le; Huang Suyun; Shengdong Huang; Liwei Wang; Keping Xie
View articletitled, Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis
Supplementary data
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BMP4 Promotes Prostate Tumor Growth in Bone through Osteogenesis
Yu-Chen Lee; Chien-Jui Cheng; Mehmet A. Bilen; Jing-Fang Lu; Robert L. Satcher; Li-Yuan Yu-Lee; Gary E. Gallick; Sankar N. Maity; Sue-Hwa Lin
View articletitled, <strong>BMP4 Promotes Prostate Tumor Growth in Bone through Osteogenesis</strong>
Supplementary data
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Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition
Jonathan L. Coloff; Andrew N. Macintyre; Amanda G. Nichols; Tingyu Liu; Catherine A. Gallo; David R. Plas; Jeffrey C. Rathmell
View articletitled, Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition
Supplementary data
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MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
Ahmed Fawzy Ibrahim; Ulrike Weirauch; Maren Thomas; Arnold Grünweller; Roland K. Hartmann; Achim Aigner
View articletitled, MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
Supplementary data
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Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets
Yan Ding; Dan Huang; Zhongfa Zhang; Josh Smith; David Petillo; Brendan D. Looyenga; Kristin Feenstra; Jeffrey P. MacKeigan; Kyle A. Furge; Bin T. Teh
View articletitled, Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets
Supplementary data
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Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy
Ryan B. Rountree; Stefanie J. Mandl; James M. Nachtwey; Katie Dalpozzo; Lisa Do; John R. Lombardo; Peter L. Schoonmaker; Kay Brinkmann; Ulrike Dirmeier; Reiner Laus; Alain Delcayre
View articletitled, Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy
Supplementary data
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Retinoic Acid Enhances TRAIL-Induced Apoptosis in Cancer Cells by Upregulating TRAIL Receptor 1 Expression
Latha Dhandapani; Ping Yue; Suresh S. Ramalingam; Fadlo R. Khuri; Shi-Yong Sun
View articletitled, Retinoic Acid Enhances TRAIL-Induced Apoptosis in Cancer Cells by Upregulating TRAIL Receptor 1 Expression
Supplementary data
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A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
Ralph Tiedt; Elisa Degenkolbe; Pascal Furet; Brent A. Appleton; Sabrina Wagner; Joseph Schoepfer; Emily Buck; David A. Ruddy; John E. Monahan; Michael D. Jones; Jutta Blank; Dorothea Haasen; Peter Drueckes; Markus Wartmann; Clive McCarthy; William R. Sellers; Francesco Hofmann
View articletitled, A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
Supplementary data
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Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Patrick A. Mayes; Nathan G. Dolloff; Colin J. Daniel; J. Judy Liu; Lori S. Hart; Kageaki Kuribayashi; Joshua E. Allen; David I.H. Jee; Jay F. Dorsey; Yingqiu Y. Liu; David T. Dicker; J. Martin Brown; Emma E. Furth; Peter S. Klein; Rosalie C. Sears; Wafik S. El-Deiry
View articletitled, Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Supplementary data
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Tumor and Stem Cell Biology

Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells
Sophia L. Maund; Wendy W. Barclay; Laura D. Hover; Linara S. Axanova; Guangchao Sui; Jason D. Hipp; James C. Fleet; Andrew Thorburn; Scott D. Cramer
View articletitled, Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D<sub>3</sub> in Prostate Progenitor/Stem Cells
Supplementary data
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PTEN Positively Regulates UVB-Induced DNA Damage Repair
Mei Ming; Li Feng; Christopher R. Shea; Keyoumars Soltani; Baozhong Zhao; Weinong Han; Robert C. Smart; Carol S. Trempus; Yu-Ying He
View articletitled, PTEN Positively Regulates UVB-Induced DNA Damage Repair
Supplementary data
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IL-8 Signaling Plays a Critical Role in the Epithelial–Mesenchymal Transition of Human Carcinoma Cells
Romaine I. Fernando; Marianne D. Castillo; Mary Litzinger; Duane H. Hamilton; Claudia Palena
View articletitled, IL-8 Signaling Plays a Critical Role in the Epithelial–Mesenchymal Transition of Human Carcinoma Cells
Supplementary data
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ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients
Brian J. Wilson; Tobias Schatton; Qian Zhan; Martin Gasser; Jie Ma; Karim R. Saab; Robin Schanche; Ana-Maria Waaga-Gasser; Jason S. Gold; Qin Huang; George F. Murphy; Markus H. Frank; Natasha Y. Frank
View articletitled, ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients
Supplementary data
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Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative
Adrian Biddle; Xiao Liang; Luke Gammon; Bilal Fazil; Lisa J. Harper; Helena Emich; Daniela Elena Costea; Ian C. Mackenzie
View articletitled, Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative
Supplementary data
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ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis
Jiro Kato; Jianfeng Zhu; Chengyu Liu; Mario Stylianou; Victoria Hoffmann; Martin J. Lizak; Connie G. Glasgow; Joel Moss
View articletitled, ADP-Ribosylarginine Hydrolase Regulates Cell Proliferation and Tumorigenesis
Supplementary data
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Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells
Leah E. Colvin Wanshura; Katherine E. Galvin; Hong Ye; Martin E. Fernandez-Zapico; Cynthia Wetmore
View articletitled, Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells
Supplementary data
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Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche
Cristina Grange; Marta Tapparo; Federica Collino; Loriana Vitillo; Christian Damasco; Maria Chiara Deregibus; Ciro Tetta; Benedetta Bussolati; Giovanni Camussi
View articletitled, Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche
Supplementary data
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Letters to the Editor

MicroRNA Expression and Outcome in Resected NSCLC—Letter
Shun-ichiro Kageyama; Yusuke Takagi; Takeshi Sawada; Natsuko Kageyama-Yahara; Masahiko Shibuya
View articletitled, MicroRNA Expression and Outcome in Resected NSCLC—Letter
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MicroRNA Expression and Outcome in Resected NSCLC—Response
Johannes Voortman; Aaron J. Schetter; Curtis C. Harris; Giuseppe Giaccone
View articletitled, MicroRNA Expression and Outcome in Resected NSCLC—Response
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Corrections

Correction: Effects of Carbon Ion Beam on Putative Colon Cancer Stem Cells and Its Comparison with X-rays
View articletitled, Correction: Effects of Carbon Ion Beam on Putative Colon Cancer Stem Cells and Its Comparison with X-rays
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Correction: A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors
View articletitled, Correction: A Requirement of STAT3 DNA Binding Precludes Th-1 Immunostimulatory Gene Expression by NF-κB in Tumors
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  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

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