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1 November 2010
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Cover Image
Cover Image
9L gliosarcoma cells expressing cel-miR-67 transfer cel-miR-67 to naïve 9L cells. Coculture of cel-miR-67–expressing 9L cells with those that expressed a luciferase reporter containing a complementary sequence to cel-miR-67 results in suppression of luciferase protein expression in the acceptor cells. This image reveals colocalization of cel-miR-67 (dark dots, in situ hybridization signal) with eGFP in 9L cells that do not express cel-miR-67. These findings indicate that glioma cells can transfer functional miRNA from one cell to another. Thus, miRNA serves as an intercellular signaling molecule in glioma. For details, see the article by Katakowski and colleagues on page 8259 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Priority Reports
Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma
Yun-Han Lee; Jesper B. Andersen; Ho-Taek Song; Adam D. Judge; Daekwan Seo; Tsuyoshi Ishikawa; Jens U. Marquardt; Mitsuteru Kitade; Marian E. Durkin; Chiara Raggi; Hyun Goo Woo; Elizabeth A. Conner; Itzhak Avital; Ian MacLachlan; Valentina M. Factor; Snorri S. Thorgeirsson
Transcriptome Analysis Reveals that p53 and β-Catenin Alterations Occur in a Group of Aggressive Adrenocortical Cancers
Bruno Ragazzon; Rossella Libé; Sébastien Gaujoux; Guillaume Assié; Amato Fratticci; Pierre Launay; Eric Clauser; Xavier Bertagna; Frédérique Tissier; Aurélien de Reyniès; Jérôme Bertherat
Clinical Studies
MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma
Johannes Voortman; Akiteru Goto; Jean Mendiboure; Jane J. Sohn; Aaron J. Schetter; Motonobu Saito; Ariane Dunant; Trung C. Pham; Iacopo Petrini; Alan Lee; Mohammed A. Khan; Pierre Hainaut; Jean-Pierre Pignon; Elisabeth Brambilla; Helmut H. Popper; Martin Filipits; Curtis C. Harris; Giuseppe Giaccone
Integrated Systems and Technologies
Integrated Microfluidic and Imaging Platform for a Kinase Activity Radioassay to Analyze Minute Patient Cancer Samples
Cong Fang; Yanju Wang; Nam T. Vu; Wei-Yu Lin; Yao-Te Hsieh; Liudmilla Rubbi; Michael E. Phelps; Markus Müschen; Yong-Mi Kim; Arion F. Chatziioannou; Hsian-Rong Tseng; Thomas G. Graeber
Microenvironment and Immunology
Tumor-Reactive CD8+ Early Effector T Cells Identified at Tumor Site in Primary and Metastatic Melanoma
Andrea Anichini; Alessandra Molla; Claudia Vegetti; Ilaria Bersani; Roberta Zappasodi; Flavio Arienti; Fernando Ravagnani; Andrea Maurichi; Roberto Patuzzo; Mario Santinami; Hanspeter Pircher; Massimo Di Nicola; Roberta Mortarini
Molecular and Cellular Pathobiology
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia
Tomoyuki Okumura; Russell E. Ericksen; Shigeo Takaishi; Sophie S.W. Wang; Zinaida Dubeykovskiy; Wataru Shibata; Kelly S. Betz; Sureshkuma Muthupalani; Arlin B. Rogers; James G. Fox; Anil K. Rustgi; Timothy C. Wang
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance
Natalie E. Simpson; W. Marcus Lambert; Renecia Watkins; Shah Giashuddin; S. Joseph Huang; Ellinor Oxelmark; Rezina Arju; Tsivia Hochman; Judith D. Goldberg; Robert J. Schneider; Luiz Fernando Lima Reiz; Fernando Augusto Soares; Susan K. Logan; Michael J. Garabedian
Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence
Peter L.J. de Keizer; Leisl M. Packer; Anna A. Szypowska; Paulien E. Riedl-Polderman; Niels J.F. van den Broek; Alain de Bruin; Tobias B. Dansen; Richard Marais; Arjan B. Brenkman; Boudewijn M.T. Burgering
A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-modulation of the Estrogen Receptor in HER2-Positive Breast Cancers
Josep Lluís Parra-Palau; Kim Pedersen; Vicente Peg; Maurizio Scaltriti; Pier Davide Angelini; Marta Escorihuela; Sandra Mancilla; Alexandre Sánchez Pla; Santiago Ramón y Cajal; José Baselga; Joaquín Arribas
Prevention and Epidemiology
Danger Signaling Protein HMGB1 Induces a Distinct Form of Cell Death Accompanied by Formation of Giant Mitochondria
Georg Gdynia; Martina Keith; Jürgen Kopitz; Marion Bergmann; Anne Fassl; Alexander N.R. Weber; Julie George; Tim Kees; Hans-Walter Zentgraf; Otmar D. Wiestler; Peter Schirmacher; Wilfried Roth
Detection of Elevated Plasma Levels of Epidermal Growth Factor Receptor Before Breast Cancer Diagnosis among Hormone Therapy Users
Sharon J. Pitteri; Lynn M. Amon; Tina Busald Buson; Yuzheng Zhang; Melissa M. Johnson; Alice Chin; Jacob Kennedy; Chee-Hong Wong; Qing Zhang; Hong Wang; Paul D. Lampe; Ross L. Prentice; Martin W. McIntosh; Samir M. Hanash; Christopher I. Li
Therapeutics, Targets, and Chemical Biology
DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue
Sari Jäämaa; Taija M. af Hällström; Anna Sankila; Ville Rantanen; Hannu Koistinen; Ulf-Håkan Stenman; Zhewei Zhang; Zhiming Yang; Angelo M. De Marzo; Kimmo Taari; Mirja Ruutu; Leif C. Andersson; Marikki Laiho
γ-Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment
Ajaikumar B. Kunnumakkara; Bokyung Sung; Jayaraj Ravindran; Parmeswaran Diagaradjane; Amit Deorukhkar; Sanjit Dey; Cemile Koca; Vivek R. Yadav; Zhimin Tong; Juri G. Gelovani; Sushovan Guha; Sunil Krishnan; Bharat B. Aggarwal
Loss of PTEN Expression by Blocking Nuclear Translocation of EGR1 in Gefitinib-Resistant Lung Cancer Cells Harboring Epidermal Growth Factor Receptor–Activating Mutations
Chizuko Yamamoto; Yuji Basaki; Akihiko Kawahara; Kazutaka Nakashima; Masayoshi Kage; Hiroto Izumi; Kimitoshi Kohno; Hidetaka Uramoto; Kosei Yasumoto; Michihiko Kuwano; Mayumi Ono
Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas
Jenny C. Potratz; Darren N. Saunders; Daniel H. Wai; Tony L. Ng; Steven E. McKinney; Joan M. Carboni; Marco M. Gottardis; Timothy J. Triche; Heribert Jürgens; Michael N. Pollak; Samuel A. Aparicio; Poul H.B. Sorensen
Tumor and Stem Cell Biology
EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF
Yu-Ting Chou; Hua-Heng Lin; Yung-Chang Lien; Yuan-Hung Wang; Chun-Fu Hong; Yu-Rung Kao; Sheng-Chieh Lin; Ying-Che Chang; Shu-Yu Lin; Shu-Jen Chen; Hua-Chien Chen; Shauh-Der Yeh; Cheng-Wen Wu
Prognostic and Therapeutic Implications of Distinct Kinase Expression Patterns in Different Subtypes of Breast Cancer
Giampaolo Bianchini; Takayuki Iwamoto; Yuan Qi; Charles Coutant; Christine Y. Shiang; Bailang Wang; Libero Santarpia; Vicente Valero; Gabriel N. Hortobagyi; W. Fraser Symmans; Luca Gianni; Lajos Pusztai
Protein Tyrosine Phosphatase Receptor Type γ Is a Functional Tumor Suppressor Gene Specifically Downregulated in Chronic Myeloid Leukemia
Marco Della Peruta; Giovanni Martinelli; Elisabetta Moratti; Davide Pintani; Marzia Vezzalini; Andrea Mafficini; Tiziana Grafone; Ilaria Iacobucci; Simona Soverini; Marco Murineddu; Fabrizio Vinante; Cristina Tecchio; Giovanna Piras; Attilio Gabbas; Maria Monne; Claudio Sorio
Corrections
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