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Volume 70, Issue 20
15 October 2010
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    Tubulin-based microtentacles facilitate epithelial-endothelial attachment. Confocal imaging of human mammary epithelial cells (HMLE) transfected with GFP-Membrane (green) engaging a confluent monolayer of mCherry-labeled (red) human bone endothelial cells. Top, angle, and side views show that HMLE cells remain rounded without observable microtentacles (left vertical panel set). HMLE cells that have undergone an epithelial-to-mesenchymal transition via stable Twist expression display microtentacles, which increase endothelial cell attachment (right vertical panel set). For details, see the article by Whipple et al. on page 8127 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, Highlights from Recent Cancer Literature
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Review

Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells
Michael A. Matrone; Rebecca A. Whipple; Eric M. Balzer; Stuart S. Martin
View articletitled, Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells
Supplementary data
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Priority Report

Mesenchymal Stromal Cells Expressing ErbB-2/neu Elicit Protective Antibreast Tumor Immunity In vivo, Which Is Paradoxically Suppressed by IFN-γ and Tumor Necrosis Factor-α Priming
Raphaëlle Romieu-Mourez; Moïra François; Amanda Abate; Marie-Noëlle Boivin; Elena Birman; Dana Bailey; Jonathan L. Bramson; Kathy Forner; Yoon-Kow Young; Jeffrey A. Medin; Jacques Galipeau
View articletitled, Mesenchymal Stromal Cells Expressing ErbB-2/<em>neu</em> Elicit Protective Antibreast Tumor Immunity <em>In vivo</em>, Which Is Paradoxically Suppressed by IFN-γ and Tumor Necrosis Factor-α Priming
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Integrated Systems and Technologies

Optical Detection of Buccal Epithelial Nanoarchitectural Alterations in Patients Harboring Lung Cancer: Implications for Screening
Hemant K. Roy; Hariharan Subramanian; Dhwanil Damania; Thomas A. Hensing; William N. Rom; Harvey I. Pass; Daniel Ray; Jeremy D. Rogers; Andrej Bogojevic; Maitri Shah; Tomasz Kuzniar; Prabhakar Pradhan; Vadim Backman
View articletitled, Optical Detection of Buccal Epithelial Nanoarchitectural Alterations in Patients Harboring Lung Cancer: Implications for Screening
Supplementary data
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In silico Modeling and In vivo Efficacy of Cancer-Preventive Vaccinations
Arianna Palladini; Giordano Nicoletti; Francesco Pappalardo; Annalisa Murgo; Valentina Grosso; Valeria Stivani; Marianna L. Ianzano; Agnese Antognoli; Stefania Croci; Lorena Landuzzi; Carla De Giovanni; Patrizia Nanni; Santo Motta; Pier-Luigi Lollini
View articletitled, <em>In silico</em> Modeling and <em>In vivo</em> Efficacy of Cancer-Preventive Vaccinations
Supplementary data
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Microenvironment and Immunology

Oncogene-Driven Intrinsic Inflammation Induces Leukocyte Production of Tumor Necrosis Factor That Critically Contributes to Mammary Carcinogenesis
Sabina Sangaletti; Claudio Tripodo; Chiara Ratti; Silvia Piconese; Rossana Porcasi; Rosalba Salcedo; Giorgio Trinchieri; Mario P. Colombo; Claudia Chiodoni
View articletitled, Oncogene-Driven Intrinsic Inflammation Induces Leukocyte Production of Tumor Necrosis Factor That Critically Contributes to Mammary Carcinogenesis
Supplementary data
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Receptor Tyrosine Kinase Signaling Favors a Protumorigenic State in Breast Cancer Cells by Inhibiting the Adaptive Immune Response
Josie Ursini-Siegel; Sean Cory; Dongmei Zuo; William R. Hardy; Elton Rexhepaj; Sonya Lam; Babette Schade; Karin Jirstrom; Eva Bjur; Ciriaco A. Piccirillo; David DeNardo; Lisa M. Coussens; Donal J. Brennan; William M. Gallagher; Morag Park; Tony Pawson; Michael Hallett; William J. Muller
View articletitled, Receptor Tyrosine Kinase Signaling Favors a Protumorigenic State in Breast Cancer Cells by Inhibiting the Adaptive Immune Response
Supplementary data
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Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma
Katjana Klages; Christian T. Mayer; Katharina Lahl; Christoph Loddenkemper; Michele W.L. Teng; Shin Foong Ngiow; Mark J. Smyth; Alf Hamann; Jochen Huehn; Tim Sparwasser
View articletitled, Selective Depletion of Foxp3<sup>+</sup> Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma
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Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth
Michele W.L. Teng; Shin Foong Ngiow; Bianca von Scheidt; Nicole McLaughlin; Tim Sparwasser; Mark J. Smyth
View articletitled, Conditional Regulatory T-Cell Depletion Releases Adaptive Immunity Preventing Carcinogenesis and Suppressing Established Tumor Growth
Supplementary data
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Molecular and Cellular Pathobiology

Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail
Cheng Du; Chuanyou Zhang; Sazzad Hassan; Md. Helal Uddin Biswas; K.C. Balaji
View articletitled, Protein Kinase D1 Suppresses Epithelial-to-Mesenchymal Transition through Phosphorylation of Snail
Supplementary data
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eIF2α Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1α
Andreas I. Papadakis; Efrosyni Paraskeva; Philippos Peidis; Hala Muaddi; Suiyang Li; Leda Raptis; Kostas Pantopoulos; George Simos; Antonis E. Koromilas
View articletitled, eIF2α Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1α
Supplementary data
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H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM
Min-Wei Chen; Kuo-Tai Hua; Hsin-Jung Kao; Chia-Chun Chi; Lin-Hung Wei; Gunnar Johansson; Shine-Gwo Shiah; Pai-Sheng Chen; Yung-Ming Jeng; Tsu-Yao Cheng; Tsung-Ching Lai; Jeng-Shou Chang; Yi-Hua Jan; Ming-Hsien Chien; Chih-Jen Yang; Ming-Shyan Huang; Michael Hsiao; Min-Liang Kuo
View articletitled, H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM
Supplementary data
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microRNA Signature and Expression of Dicer and Drosha Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma
Ruey-Jen Lin; You-Chin Lin; Jeremy Chen; Huan-Hsien Kuo; Yuan-Yan Chen; Mitchell B. Diccianni; Wendy B. London; Chih-Hao Chang; Alice L. Yu
View articletitled, microRNA Signature and Expression of <em>Dicer</em> and <em>Drosha</em> Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma
Supplementary data
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Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
Nami Sugiyama; Markku Varjosalo; Pipsa Meller; Jouko Lohi; Marko Hyytiäinen; Sami Kilpinen; Olli Kallioniemi; Signe Ingvarsen; Lars H. Engelholm; Jussi Taipale; Kari Alitalo; Jorma Keski-Oja; Kaisa Lehti
View articletitled, Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
Supplementary data
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HER-2 Signaling, Acquisition of Growth Factor Independence, and Regulation of Biological Networks Associated with Cell Transformation
Aliccia Bollig-Fischer; Michele Dziubinski; Alaina Boyer; Ramsi Haddad; Craig N. Giroux; Stephen P. Ethier
View articletitled, HER-2 Signaling, Acquisition of Growth Factor Independence, and Regulation of Biological Networks Associated with Cell Transformation
Supplementary data
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MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation
Sudipto Das; Niamh Foley; Kenneth Bryan; Karen M. Watters; Isabella Bray; Derek M. Murphy; Patrick G. Buckley; Raymond L. Stallings
View articletitled, MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation
Supplementary data
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The RB-E2F1 Pathway Regulates Autophagy
Hong Jiang; Vanesa Martin; Candelaria Gomez-Manzano; David G. Johnson; Marta Alonso; Erin White; Jing Xu; Timothy J. McDonnell; Naoki Shinojima; Juan Fueyo
View articletitled, The RB-E2F1 Pathway Regulates Autophagy
Supplementary data
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Ratio of miR-196s to HOXC8 Messenger RNA Correlates with Breast Cancer Cell Migration and Metastasis
Yong Li; Maoxiang Zhang; Huijun Chen; Zheng Dong; Vadivel Ganapathy; Muthusamy Thangaraju; Shuang Huang
View articletitled, Ratio of miR-196s to HOXC8 Messenger RNA Correlates with Breast Cancer Cell Migration and Metastasis
Supplementary data
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RasGRP3 Contributes to Formation and Maintenance of the Prostate Cancer Phenotype
Dazhi Yang; Noemi Kedei; Luowei Li; Juan Tao; Julia F. Velasquez; Aleksandra M. Michalowski; Balázs I. Tóth; Rita Marincsák; Attila Varga; Tamás Bíró; Stuart H. Yuspa; Peter M. Blumberg
View articletitled, RasGRP3 Contributes to Formation and Maintenance of the Prostate Cancer Phenotype
Supplementary data
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Nucleotide Excision Repair Gene Expression after Cisplatin Treatment in Melanoma
Nikola A. Bowden; Katie A. Ashton; Kelly A. Avery-Kiejda; Xu Dong Zhang; Peter Hersey; Rodney J. Scott
View articletitled, Nucleotide Excision Repair Gene Expression after Cisplatin Treatment in Melanoma
Supplementary data
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Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and α5 Integrin Upregulation
Jodi A. McKenzie; Tong Liu; Agnessa G. Goodson; Douglas Grossman
View articletitled, Survivin Enhances Motility of Melanoma Cells by Supporting Akt Activation and α5 Integrin Upregulation
Supplementary data
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Keratinocyte-Specific Stat3 Heterozygosity Impairs Development of Skin Tumors in Human Papillomavirus 8 Transgenic Mice
Marco De Andrea; Massimo Rittà; Manuela M. Landini; Cinzia Borgogna; Michele Mondini; Florian Kern; Karin Ehrenreiter; Manuela Baccarini; Gian Paolo Marcuzzi; Sigrun Smola; Herbert Pfister; Santo Landolfo; Marisa Gariglio
View articletitled, Keratinocyte-Specific Stat3 Heterozygosity Impairs Development of Skin Tumors in Human Papillomavirus 8 Transgenic Mice
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Expression of the Transcriptional Repressor Gfi-1 Is Regulated by C/EBPα and Is Involved in Its Proliferation and Colony Formation–Inhibitory Effects in p210BCR/ABL-Expressing Cells
Maria Rosa Lidonnici; Alessandra Audia; Angela Rachele Soliera; Marco Prisco; Giovanna Ferrari-Amorotti; Todd Waldron; Nick Donato; Ying Zhang; Robert V. Martinez; Tessa L. Holyoake; Bruno Calabretta
View articletitled, Expression of the Transcriptional Repressor Gfi-1 Is Regulated by C/EBPα and Is Involved in Its Proliferation and Colony Formation–Inhibitory Effects in p210BCR/ABL-Expressing Cells
Supplementary data
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Prevention and Epidemiology

Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis
Hillary L. Woodworth; Sarah J. McCaskey; David M. Duriancik; Jonathan F. Clinthorne; Ingeborg M. Langohr; Elizabeth M. Gardner; Jenifer I. Fenton
View articletitled, Dietary Fish Oil Alters T Lymphocyte Cell Populations and Exacerbates Disease in a Mouse Model of Inflammatory Colitis
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Therapeutics, Targets, and Chemical Biology

Synergistic Chemosensitivity of Triple-Negative Breast Cancer Cell Lines to Poly(ADP-Ribose) Polymerase Inhibition, Gemcitabine, and Cisplatin
Kedar Hastak; Elizabeth Alli; James M. Ford
View articletitled, Synergistic Chemosensitivity of Triple-Negative Breast Cancer Cell Lines to Poly(ADP-Ribose) Polymerase Inhibition, Gemcitabine, and Cisplatin
Supplementary data
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Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters
Yan-jun Mi; Yong-ju Liang; Hong-bing Huang; Hong-yun Zhao; Chung-Pu Wu; Fang Wang; Li-yang Tao; Chuan-zhao Zhang; Chun-Ling Dai; Amit K. Tiwari; Xiao-xu Ma; Kenneth Kin Wah To; Suresh V. Ambudkar; Zhe-Sheng Chen; Li-wu Fu
View articletitled, Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters
Supplementary data
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Tubulin-Targeting Chemotherapy Impairs Androgen Receptor Activity in Prostate Cancer
Meng-Lei Zhu; Craig M. Horbinski; Mark Garzotto; David Z. Qian; Tomasz M. Beer; Natasha Kyprianou
View articletitled, Tubulin-Targeting Chemotherapy Impairs Androgen Receptor Activity in Prostate Cancer
Supplementary data
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Role of LIM and SH3 Protein 1 (LASP1) in the Metastatic Dissemination of Medulloblastoma
Christopher Traenka; Marc Remke; Andrey Korshunov; Sebastian Bender; Thomas Hielscher; Paul A. Northcott; Hendrik Witt; Marina Ryzhova; Jörg Felsberg; Axel Benner; Stephanie Riester; Wolfram Scheurlen; Thomas G.P. Grunewald; Andreas von Deimling; Andreas E. Kulozik; Guido Reifenberger; Michael D. Taylor; Peter Lichter; Elke Butt; Stefan M. Pfister
View articletitled, Role of LIM and SH3 Protein 1 (LASP1) in the Metastatic Dissemination of Medulloblastoma
Supplementary data
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Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
Hariharan P. Easwaran; Leander Van Neste; Leslie Cope; Subhojit Sen; Helai P. Mohammad; Gayle J. Pageau; Jeanne B. Lawrence; James G. Herman; Kornel E. Schuebel; Stephen B. Baylin
View articletitled, Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
Supplementary data
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Cell Surface Tetraspanin CD9 Mediates Chemoresistance in Small Cell Lung Cancer
Satoshi Kohmo; Takashi Kijima; Yasushi Otani; Masahide Mori; Toshiyuki Minami; Ryo Takahashi; Izumi Nagatomo; Yoshito Takeda; Hiroshi Kida; Sho Goya; Mitsuhiro Yoshida; Toru Kumagai; Isao Tachibana; Soichiro Yokota; Ichiro Kawase
View articletitled, Cell Surface Tetraspanin CD9 Mediates Chemoresistance in Small Cell Lung Cancer
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A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF
Steven Whittaker; Delphine Ménard; Ruth Kirk; Lesley Ogilvie; Douglas Hedley; Alfonso Zambon; Filipa Lopes; Natasha Preece; Helen Manne; Sareena Rana; Maryou Lambros; Jorge S. Reis-Filho; Richard Marais; Caroline J. Springer
View articletitled, A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
Supplementary data
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Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
Norman Chan; Isabel M. Pires; Zuzana Bencokova; Carla Coackley; Kaisa R. Luoto; Nirmal Bhogal; Minalini Lakshman; Ponnari Gottipati; F. Javier Oliver; Thomas Helleday; Ester M. Hammond; Robert G. Bristow
View articletitled, Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
Supplementary data
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Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors
Stéphanie Solier; Jennifer Barb; Barry R. Zeeberg; Sudhir Varma; Mike C. Ryan; Kurt W. Kohn; John N. Weinstein; Peter J. Munson; Yves Pommier
View articletitled, Genome-wide Analysis of Novel Splice Variants Induced by Topoisomerase I Poisoning Shows Preferential Occurrence in Genes Encoding Splicing Factors
Supplementary data
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Aerobic Glycolysis Suppresses p53 Activity to Provide Selective Protection from Apoptosis upon Loss of Growth Signals or Inhibition of BCR-Abl
Emily F. Mason; Yuxing Zhao; Pankuri Goraksha-Hicks; Jonathan L. Coloff; Hugh Gannon; Stephen N. Jones; Jeffrey C. Rathmell
View articletitled, Aerobic Glycolysis Suppresses p53 Activity to Provide Selective Protection from Apoptosis upon Loss of Growth Signals or Inhibition of BCR-Abl
Supplementary data
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hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy
Eran Elyakim; Einat Sitbon; Alexander Faerman; Sarit Tabak; Eve Montia; Liron Belanis; Avital Dov; Eric G. Marcusson; C. Frank Bennett; Ayelet Chajut; Dalia Cohen; Noga Yerushalmi
View articletitled, hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy
Supplementary data
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Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 Hyperactivation
Ying Dong; Erik A. Bey; Long-Shan Li; Wareef Kabbani; Jingsheng Yan; Xian-Jin Xie; Jer-Tsong Hsieh; Jinming Gao; David A. Boothman
View articletitled, Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 Hyperactivation
Supplementary data
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Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
Francesca Chiarini; Cecilia Grimaldi; Francesca Ricci; Pier Luigi Tazzari; Camilla Evangelisti; Andrea Ognibene; Michela Battistelli; Elisabetta Falcieri; Fraia Melchionda; Andrea Pession; Pasqualepaolo Pagliaro; James A. McCubrey; Alberto M. Martelli
View articletitled, Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
Supplementary data
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IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3–Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced Apoptosis
Chuan He Yang; Junming Yue; Meiyun Fan; Lawrence M. Pfeffer
View articletitled, IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3–Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced Apoptosis
Supplementary data
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Tumor and Stem Cell Biology

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman; Koen Brusselmans; Katryn Scheys; Leen Timmermans; Rita Derua; Sebastian Munck; Paul P. Van Veldhoven; David Waltregny; Veerle W. Daniëls; Jelle Machiels; Frank Vanderhoydonc; Karine Smans; Etienne Waelkens; Guido Verhoeven; Johannes V. Swinnen
View articletitled, <em>De novo</em> Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Supplementary data
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Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement
Rebecca A. Whipple; Michael A. Matrone; Edward H. Cho; Eric M. Balzer; Michele I. Vitolo; Jennifer R. Yoon; Olga B. Ioffe; Kimberly C. Tuttle; Jing Yang; Stuart S. Martin
View articletitled, Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement
Supplementary data
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Chemotrap-1: An Engineered Soluble Receptor That Blocks Chemokine-Induced Migration of Metastatic Cancer Cells In vivo
Silvia Lanati; Darryl B. Dunn; Myriam Roussigné; Maxine S. Emmett; Virginie Carriere; Denis Jullien; Jessica Budge; Justin Fryer; Monique Erard; Françoise Cailler; Jean-Phillippe Girard; David O. Bates
View articletitled, Chemotrap-1: An Engineered Soluble Receptor That Blocks Chemokine-Induced Migration of Metastatic Cancer Cells <em>In vivo</em>
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Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss
Alicia M. Cole; Kevin Myant; Karen R. Reed; Rachel A. Ridgway; Dimitris Athineos; Gijs R. Van den Brink; Vanesa Muncan; Hans Clevers; Alan R. Clarke; Peter Sicinski; Owen J. Sansom
View articletitled, Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss
Supplementary data
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Carcinoembryonic Antigen Interacts with TGF-β Receptor and Inhibits TGF-β Signaling in Colorectal Cancers
Ying Li; Hong Cao; Zhongxian Jiao; Suresh B. Pakala; Divijendra Natha Reddy Sirigiri; Wenpin Li; Rakesh Kumar; Lopa Mishra
View articletitled, Carcinoembryonic Antigen Interacts with TGF-β Receptor and Inhibits TGF-β Signaling in Colorectal Cancers
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Unique DNA Methylation Patterns Distinguish Noninvasive and Invasive Urothelial Cancers and Establish an Epigenetic Field Defect in Premalignant Tissue
Erika M. Wolff; Yoshitomo Chihara; Fei Pan; Daniel J. Weisenberger; Kimberly D. Siegmund; Kokichi Sugano; Kiyotaka Kawashima; Peter W. Laird; Peter A. Jones; Gangning Liang
View articletitled, Unique DNA Methylation Patterns Distinguish Noninvasive and Invasive Urothelial Cancers and Establish an Epigenetic Field Defect in Premalignant Tissue
Supplementary data
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Impact of Stromal Sensitivity on Radiation Response of Tumors Implanted in SCID Hosts Revisited
Mónica García-Barros; Tin Htwe Thin; Jerzy Maj; Carlos Cordon-Cardo; Adriana Haimovitz-Friedman; Zvi Fuks; Richard Kolesnick
View articletitled, Impact of Stromal Sensitivity on Radiation Response of Tumors Implanted in SCID Hosts Revisited
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Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration
Jessica L. Fry; Alex Toker
View articletitled, Secreted and Membrane-Bound Isoforms of Protease ADAM9 Have Opposing Effects on Breast Cancer Cell Migration
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Silencing of Thrombospondin-1 Is Critical for Myc-Induced Metastatic Phenotypes in Medulloblastoma
Limei Zhou; Daniel Picard; Young-Shin Ra; Meihua Li; Paul A. Northcott; Yaqi Hu; Duncan Stearns; Cynthia Hawkins; Michael D. Taylor; James Rutka; Sandy D. Der; Annie Huang
View articletitled, Silencing of Thrombospondin-1 Is Critical for Myc-Induced Metastatic Phenotypes in Medulloblastoma
Supplementary data
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Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Mobilization of Macrophage Lineage Cells from Bone Marrow and Stimulates Solid Tumor Growth
Masashi Muramatsu; Seiji Yamamoto; Tsuyoshi Osawa; Masabumi Shibuya
View articletitled, Vascular Endothelial Growth Factor Receptor-1 Signaling Promotes Mobilization of Macrophage Lineage Cells from Bone Marrow and Stimulates Solid Tumor Growth
Supplementary data
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Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3
Li Li; Shing-hu Cheung; Emma L. Evans; Peter E. Shaw
View articletitled, Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3
Supplementary data
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The Myc–miR-17∼92 Axis Blunts TGFβ Signaling and Production of Multiple TGFβ-Dependent Antiangiogenic Factors
Michael Dews; Jamie L. Fox; Stacy Hultine; Prema Sundaram; Wenge Wang; Yingqiu Y. Liu; Emma Furth; Gregory H. Enders; Wafik El-Deiry; Janell M. Schelter; Michele A. Cleary; Andrei Thomas-Tikhonenko
View articletitled, The Myc–miR-17∼92 Axis Blunts TGFβ Signaling and Production of Multiple TGFβ-Dependent Antiangiogenic Factors
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Letters to the Editor

Intraprostatic Steroidogenic Enzymes – Letter
Elahe Mostaghel; Peter S. Nelson; Colleen Nelson; R. Bruce Montgomery
View articletitled, Intraprostatic Steroidogenic Enzymes – Letter
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Intraprostatic Steroidogenic Enzymes – Response
Johannes Hofland; Wytske M. van Weerden; Guido Jenster; Fritz H. Schröder; Frank H. de Jong
View articletitled, Intraprostatic Steroidogenic Enzymes – Response
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Corrections

Correction: The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex
View articletitled, Correction: The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex
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Correction: The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease
View articletitled, Correction: The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease
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