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15 January 2010
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Numerous epidemiological studies indicate that obesity and type 2 diabetes significantly increase breast cancer risk and mortality. The molecular mechanisms implicated in this association remain poorly understood. By employing a nonobese model of type 2 diabetes, Novosyadlyy and colleagues show that type 2 diabetes accelerates mammary gland development, formation of hyperplastic precancerous lesions, and malignant tumor growth independent of obesity. Furthermore, the authors demonstrate that hyperinsulinemia acting through the insulin and IGF-I receptors is a key pathophysiological mechanism promoting tumor development in the context of type 2 diabetes. Finally, the authors propose that interventions aimed at reducing insulin levels and signaling may delay the onset of cancer in patients with type 2 diabetes and will have an enormously positive public health impact. For details, see the article by Novosyadlyy and colleagues on page 741 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Perspective
Priority Report
Clinical Studies
Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Bruno M. Costa; Justin S. Smith; Ying Chen; Justin Chen; Heidi S. Phillips; Kenneth D. Aldape; Giuseppe Zardo; Janice Nigro; C. David James; Jane Fridlyand; Rui M. Reis; Joseph F. Costello
Integrated Systems and Technologies: Mathematical Oncology
Microenvironment and Immunology
Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands
Rosa Conforti; Yuting Ma; Yannis Morel; Carine Paturel; Magali Terme; Sophie Viaud; Bernard Ryffel; Maria Ferrantini; Ravindra Uppaluri; Robert Schreiber; Christophe Combadière; Nathalie Chaput; Fabrice André; Guido Kroemer; Laurence Zitvogel
Molecular and Cellular Pathobiology
Oncogenic BRAF Mutation with CDKN2A Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas
Joshua D. Schiffman; J. Graeme Hodgson; Scott R. VandenBerg; Patrick Flaherty; Mei-Yin C. Polley; Mamie Yu; Paul G. Fisher; David H. Rowitch; James M. Ford; Mitchel S. Berger; Hanlee Ji; David H. Gutmann; C. David James
Insertional Mutagenesis in Mice Deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes
Jaap Kool; Anthony G. Uren; Carla P. Martins; Daoud Sie; Jeroen de Ridder; Geoffrey Turner; Miranda van Uitert; Konstantin Matentzoglu; Wendy Lagcher; Paul Krimpenfort; Jules Gadiot; Colin Pritchard; Jack Lenz; Anders H. Lund; Jos Jonkers; Jane Rogers; David J. Adams; Lodewyk Wessels; Anton Berns; Maarten van Lohuizen
Prevention and Epidemiology
Use of Four Biomarkers to Evaluate the Risk of Breast Cancer Subtypes in the Women's Contraceptive and Reproductive Experiences Study
Huiyan Ma; Yaping Wang; Jane Sullivan-Halley; Linda Weiss; Polly A. Marchbanks; Robert Spirtas; Giske Ursin; Ronald T. Burkman; Michael S. Simon; Kathleen E. Malone; Brian L. Strom; Jill A. McDonald; Michael F. Press; Leslie Bernstein
Therapeutics, Targets, and Chemical Biology
Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction
Andrew J. Wilson; Anderly C. Chueh; Lars Tögel; Georgia A. Corner; Naseem Ahmed; Sanjay Goel; Do-Sun Byun; Shannon Nasser; Michele A. Houston; Minaxi Jhawer; Helena J.M. Smartt; Lucas B. Murray; Courtney Nicholas; Barbara G. Heerdt; Diego Arango; Leonard H. Augenlicht; John M. Mariadason
Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
Ker Yu; Celine Shi; Lourdes Toral-Barza; Judy Lucas; Boris Shor; Jae Eun Kim; Wei-Guo Zhang; Robert Mahoney; Christine Gaydos; LuAnna Tardio; Sung Kyoo Kim; Roger Conant; Kevin Curran; Joshua Kaplan; Jeroen Verheijen; Semiramis Ayral-Kaloustian; Tarek S. Mansour; Robert T. Abraham; Arie Zask; James J. Gibbons
Tumor and Stem Cell Biology
Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
Ruslan Novosyadlyy; Danielle E. Lann; Archana Vijayakumar; Anne Rowzee; Deborah A. Lazzarino; Yvonne Fierz; Joan M. Carboni; Marco M. Gottardis; Patricia A. Pennisi; Alfredo A. Molinolo; Naamit Kurshan; Wilson Mejia; Stefania Santopietro; Shoshana Yakar; Teresa L. Wood; Derek LeRoith
Correction
Corrections
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