Skip to Main Content

Advertisement

American Association for Cancer Research Logo
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 70, Issue 19
1 October 2010
Cancer Research Cover Image for Volume 70, Issue 19
All Issues
  • Cover Image

    Cover Image

    issue cover
    Under proliferative conditions in vitro, epidermal growth factor receptor (EGFR)–positive cancer stem cell (CSC) cultures transduced with small hairpin RNA (shRNA) against EGFR displayed dramatic morphologic changes, with neurospheres becoming highly adhesive and cells appearing well differentiated (right). Consistently, the frequency of glial fibrillary acidic protein–positive astrocyte-like cells in shRNA-transduced CSCs was significantly increased as compared to that of controls (left). Tuj1, red; GFAP, green; merge, yellow; TOPRO-3, dark blue. Magnifications: top, 200x; bottom, 400x. For details see the article by Mazzoleni and colleagues on page 7500 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Breaking Advances

Highlights from Recent Cancer Literature
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Reviews

CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in Oncogenesis
J. Devon Roll; Gary W. Reuther
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
PALB2/FANCN: Recombining Cancer and Fanconi Anemia
Marc Tischkowitz; Bing Xia
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Meeting Reports

AACR Special Conference on Epithelial-Mesenchymal Transition and Cancer Progression and Treatment
Evanthia T. Roussos; Zuzana Keckesova; John D. Haley; David M. Epstein; Robert A. Weinberg; John S. Condeelis
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
The Role of Telomeres and Telomerase in Cancer Research
Sheila A. Stewart; Alison A. Bertuch
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Thirteenth AACR Special Conference on Cancer Epigenetics
Jason P. Ross; Peter L. Molloy
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Clinical Studies

MLH1 Founder Mutations with Moderate Penetrance in Spanish Lynch Syndrome Families
Ester Borràs; Marta Pineda; Ignacio Blanco; Ethan M. Jewett; Fei Wang; Àlex Teulé; Trinidad Caldés; Miguel Urioste; Cristina Martínez-Bouzas; Joan Brunet; Judith Balmaña; Asunción Torres; Teresa Ramón y Cajal; Judit Sanz; Lucía Pérez-Cabornero; Sergi Castellví-Bel; Ángel Alonso; Ángel Lanas; Sara González; Víctor Moreno; Stephen B. Gruber; Noah A. Rosenberg; Bhramar Mukherjee; Conxi Lázaro; Gabriel Capellá
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients
Ketan R. Patel; Victoria A. Brown; Donald J.L. Jones; Robert G. Britton; David Hemingway; Andrew S. Miller; Kevin P. West; Tristan D. Booth; Marjorie Perloff; James A. Crowell; Dean E. Brenner; William P. Steward; Andreas J. Gescher; Karen Brown
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Integrated Systems and Technologies

Hyperpolarized 13C Spectroscopic Imaging Informs on Hypoxia-Inducible Factor-1 and Myc Activity Downstream of Platelet-Derived Growth Factor Receptor
Hagit Dafni; Peder E.Z. Larson; Simon Hu; Hikari A.I. Yoshihara; Christopher S. Ward; Humsa S. Venkatesh; Chunsheng Wang; Xiaoliang Zhang; Daniel B. Vigneron; Sabrina M. Ronen
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Microenvironment and Immunology

Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in BCR-ABL1–Driven B-Cell Lineage Acute Lymphoblastic Leukemia
Tanja Andrea Gruber; Mi Sook Chang; Richard Sposto; Markus Müschen
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
ERBB Receptor Activation Is Required for Profibrotic Responses to Transforming Growth Factor β
Mahefatiana Andrianifahanana; Mark C. Wilkes; Claire E. Repellin; Maryanne Edens; Theodore J. Kottom; Rod A. Rahimi; Edward B. Leof
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Antibody-Dependent Natural Killer Cell–Mediated Cytotoxicity Engendered by a Kinase-Inactive Human HER2 Adenovirus-Based Vaccination Mediates Resistance to Breast Tumors
Chiara Triulzi; Simona Vertuani; Claudia Curcio; Agnese Antognoli; Josef Seibt; Göran Akusjärvi; Wei-Zen Wei; Federica Cavallo; Rolf Kiessling
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Amplifying TLR-MyD88 Signals within Tumor-Specific T Cells Enhances Antitumor Activity to Suboptimal Levels of Weakly Immunogenic Tumor Antigens
Degui Geng; Liqin Zheng; Ratika Srivastava; Cruz Velasco-Gonzalez; Adam Riker; Svetomir N. Markovic; Eduardo Davila
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells
Andreas Herrmann; Marcin Kortylewski; Maciej Kujawski; Chunyan Zhang; Karen Reckamp; Brian Armstrong; Lin Wang; Claudia Kowolik; Jiehui Deng; Robert Figlin; Hua Yu
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens; Christian Stockmann; Mark P. Rubinstein; Debbie Liao; Na Zhang; David G. DeNardo; Lisa M. Coussens; Michael Karin; Ananda W. Goldrath; Randall S. Johnson
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice
Nathalie Demotte; Grégoire Wieërs; Patrick Van Der Smissen; Muriel Moser; Christopher Schmidt; Kris Thielemans; Jean-Luc Squifflet; Birgit Weynand; Javier Carrasco; Christophe Lurquin; Pierre J. Courtoy; Pierre van der Bruggen
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Molecular and Cellular Pathobiology

CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Casey Trimmer; Diana Whitaker-Menezes; Gloria Bonuccelli; Janet N. Milliman; Kristin M. Daumer; Andrew E. Aplin; Richard G. Pestell; Federica Sotgia; Michael P. Lisanti; Franco Capozza
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Epidermal Growth Factor Receptor Expression Identifies Functionally and Molecularly Distinct Tumor-Initiating Cells in Human Glioblastoma Multiforme and Is Required for Gliomagenesis
Stefania Mazzoleni; Letterio S. Politi; Mauro Pala; Manuela Cominelli; Alberto Franzin; Lucia Sergi Sergi; Andrea Falini; Michele De Palma; Alessandro Bulfone; Pietro L. Poliani; Rossella Galli
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Nongenomic Effects of Cisplatin: Acute Inhibition of Mechanosensitive Transporters and Channels without Actin Remodeling
Nina Milosavljevic; Christophe Duranton; Nadir Djerbi; Pierre Henri Puech; Pierre Gounon; Dominique Lagadic-Gossmann; Marie Thérèse Dimanche-Boitrel; Cyril Rauch; Michel Tauc; Laurent Counillon; Mallorie Poët
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Interaction with Vascular Endothelium Enhances Survival in Primary Chronic Lymphocytic Leukemia Cells via NF-κB Activation and De novo Gene Transcription
Andrea G.S. Buggins; Chris Pepper; Piers E.M. Patten; Saman Hewamana; Satyen Gohil; Jane Moorhead; Najeem'deen Folarin; Deborah Yallop; N. Shaun B. Thomas; Ghulam J. Mufti; Chris Fegan; Stephen Devereux
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Prevention and Epidemiology

Circulating Levels of the Innate and Humoral Immune Regulators CD14 and CD23 Are Associated with Adult Glioma
Mi Zhou; Joseph L. Wiemels; Paige M. Bracci; Margaret R. Wrensch; Lucie S. Mccoy; Terri Rice; Jennette D. Sison; Joseph S. Patoka; John K. Wiencke
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Glucuronidation Genotypes and Nicotine Metabolic Phenotypes: Importance of Functional UGT2B10 and UGT2B17 Polymorphisms
Gang Chen; Nino E. Giambrone, Jr.; Douglas F. Dluzen; Joshua E. Muscat; Arthur Berg; Carla J. Gallagher; Philip Lazarus
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Therapeutics, Targets, and Chemical Biology

Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug
Mohanraja Kumar; Mehmet Yigit; Guangping Dai; Anna Moore; Zdravka Medarova
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate as a Probe for In vivo Positron Emission Tomography Imaging in Cancer
Ulrich auf dem Keller; Caroline L. Bellac; Ying Li; Yuanmei Lou; Philipp F. Lange; Richard Ting; Curtis Harwig; Reinhild Kappelhoff; Shoukat Dedhar; Michael J. Adam; Thomas J. Ruth; François Bénard; David M. Perrin; Christopher M. Overall
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer
Erinn B. Rankin; Katherine C. Fuh; Tiffany E. Taylor; Adam J. Krieg; Margaret Musser; Jenny Yuan; Kevin Wei; Calvin J. Kuo; Teri A. Longacre; Amato J. Giaccia
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
MET and KRAS Gene Amplification Mediates Acquired Resistance to MET Tyrosine Kinase Inhibitors
Virna Cepero; J. Rafael Sierra; Simona Corso; Elena Ghiso; Laura Casorzo; Tim Perera; Paolo Maria Comoglio; Silvia Giordano
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Anti–αv Integrin Monoclonal Antibody Intetumumab Enhances the Efficacy of Radiation Therapy and Reduces Metastasis of Human Cancer Xenografts in Nude Rats
Shoucheng Ning; Junqiang Tian; Deborah J. Marshall; Susan J. Knox
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
A Bispecific Antibody-IFNα2b Immunocytokine Targeting CD20 and HLA-DR Is Highly Toxic to Human Lymphoma and Multiple Myeloma Cells
Edmund A. Rossi; Diane L. Rossi; Rhona Stein; David M. Goldenberg; Chien-Hsing Chang
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Zoledronic Acid as a New Adjuvant Therapeutic Strategy for Ewing's Sarcoma Patients
Guillaume A. Odri; Sophie Dumoucel; Gaëlle Picarda; Séverine Battaglia; François Lamoureux; Nadège Corradini; Julie Rousseau; Franck Tirode; Karine Laud; Olivier Delattre; François Gouin; Dominique Heymann; Françoise Redini
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Liver Cancer Protease Activity Profiles Support Therapeutic Options with Matrix Metalloproteinase–Activatable Oncolytic Measles Virus
Michael D. Mühlebach; Thomas Schaser; Martina Zimmermann; Sorin Armeanu; Kay-Martin O. Hanschmann; Roberto Cattaneo; Michael Bitzer; Ulrich M. Lauer; Klaus Cichutek; Christian J. Buchholz
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling
Ailin Bai; Kristan Meetze; Nhi Y. Vo; Sriram Kollipara; Elizabeth K. Mazsa; William M. Winston; Solly Weiler; Laura L. Poling; Ting Chen; Nesreen S. Ismail; Jinwei Jiang; Lorena Lerner; Jeno Gyuris; Zhigang Weng
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Tumor and Stem Cell Biology

Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma
Bei-Fang Ning; Jin Ding; Chuan Yin; Wei Zhong; Kun Wu; Xin Zeng; Wen Yang; Yue-Xiang Chen; Jun-Ping Zhang; Xin Zhang; Hong-Yang Wang; Wei-Fen Xie
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Tumor Antigen Acrosin Binding Protein Normalizes Mitotic Spindle Function to Promote Cancer Cell Proliferation
Angelique W. Whitehurst; Yang Xie; Scott C. Purinton; Kathryn M. Cappell; Jackie T. Swanik; Brittany Larson; Luc Girard; John O. Schorge; Michael A. White
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells
Joyce E. Ohm; Prashant Mali; Leander Van Neste; David M. Berman; Liang Liang; Kurinji Pandiyan; Kimberly J. Briggs; Wei Zhang; Pedram Argani; Brian Simons; Wayne Yu; William Matsui; Wim Van Criekinge; Feyruz V. Rassool; Elias Zambidis; Kornel E. Schuebel; Leslie Cope; Jonathan Yen; Helai P. Mohammad; Linzhao Cheng; Stephen B. Baylin
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
E-Cadherin/p120-Catenin and Tetraspanin Co-029 Cooperate for Cell Motility Control in Human Colon Carcinoma
Céline Greco; Marie-Pierre Bralet; Naouel Ailane; Anne Dubart-Kupperschmitt; Eric Rubinstein; François Le Naour; Claude Boucheix
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Activation of Murine Double Minute 2 by Akt in Mammary Epithelium Delays Mammary Involution and Accelerates Mammary Tumorigenesis
Xiaoyun Cheng; Weiya Xia; Jer-Yen Yang; Jennifer L. Hsu; Jing-Yu Lang; Chao-Kai Chou; Yi Du; Hui-Lung Sun; Shannon L. Wyszomierski; Gordon B. Mills; William J. Muller; Dihua Yu; Mien-Chie Hung
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Aggressive Fibromatosis (Desmoid Tumor) Is Derived from Mesenchymal Progenitor Cells
Colleen Wu; Saied Nik-Amini; Puviindran Nadesan; William L. Stanford; Benjamin A. Alman
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies
Pei-Ming Yang; Yuan-Ling Liu; Yi-Chu Lin; Chia-Tung Shun; Ming-Shiang Wu; Ching-Chow Chen
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Mathieu Boissan; Olivier De Wever; Floria Lizarraga; Dominique Wendum; Renaud Poincloux; Nicolas Chignard; Christèle Desbois-Mouthon; Sylvie Dufour; Béatrice Nawrocki-Raby; Philippe Birembaut; Marc Bracke; Philippe Chavrier; Christian Gespach; Marie-Lise Lacombe
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window
Image-Based Chemical Screening Identifies Drug Efflux Inhibitors in Lung Cancer Cells
Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T.C. Wong
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplementary data
Open the PDF for in another window

Corrections

Correction: Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window
Correction: 6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
View articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Open the PDF for in another window

Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

Advertisement

Email alerts

eTOC Alert
Close Modal
Latest News
“A Game-Changer” HER2 TKI for NSCLC
Using Liquid Biopsy to Guide Adjuvant ICI for dMMR Tumors
Machine Learning Could Boost Skin Cancer Detection in Areas with Few Resources
View more recent articles
Breaking
Cell Atlas Examines Circadian Rhythm in TME
Pembrolizumab Boosts EFS in Head and Neck Cancer
Former NCI Director to Lead Ohio Cancer Center
View more recent articles
Research Watch
ROS Sensing Regulates Mitochondrial Translation and Chemotherapy Response
Dietary Fat Promotes Triple-Negative Breast Cancer through FABP5–mTOR
Ligand Engagement Induces LAG3 Checkpoint Activity through Ubiquitination
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck.  None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept