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1 September 2010
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Capsaicin is a principal pungent ingredient in hot peppers, which are consumed worldwide. Capsaicin has been shown to induce cancer cell death, and it has also been suggested that capsaicin may act as a carcinogen or cocarcinogen during the promotion stage of cancer. Hwang and colleagues show that capsaicin has a cocarcinogenic effect on TPA-promoted skin carcinogenesis in vivo that is mediated through the epidermal growth factor receptor (EGFR) and not the transient receptor potential vanilloid subfamily member 1 (TRPV1). Significantly, topical application of capsaicin on the dorsal skin of wild-type or TRPV1 knockout mice induced more and larger skin tumors in the knockout mice, suggesting that capsaicin acts through a TRPV1-independent mechanism. Notably, cyclooxygenase-2 (COX-2) expression was highly elevated with capsaicin treatment in TRPV1 knockout mice, and inhibitors of EGFR/MEK signaling suppressed capsaicin/TPA–induced COX-2 expression. These results raise concerns that a natural compound found in hot peppers used in over-the-counter topical pain remedies may heighten skin cancer risk by affecting EGFR-dependent signaling. For details, see the article by Hwang and colleagues on page 6859 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Priority Report
Integrated Systems and Technologies
Microenvironment and Immunology
Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
Sid P. Kerkar; Pawel Muranski; Andrew Kaiser; Andrea Boni; Luis Sanchez-Perez; Zhiya Yu; Douglas C. Palmer; Robert N. Reger; Zachary A. Borman; Ling Zhang; Richard A. Morgan; Luca Gattinoni; Steven A. Rosenberg; Giorgio Trinchieri; Nicholas P. Restifo
Molecular and Cellular Pathobiology
Spi-1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage
Pauline Rimmelé; Jun Komatsu; Philippe Hupé; Christophe Roulin; Emmanuel Barillot; Marie Dutreix; Emmanuel Conseiller; Aaron Bensimon; Françoise Moreau-Gachelin; Christel Guillouf
Prevention and Epidemiology
Human Chorionic Gonadotropin in Pregnancy and Maternal Risk of Breast Cancer
Paolo Toniolo; Kjell Grankvist; Marianne Wulff; Tianhui Chen; Robert Johansson; Helena Schock; Per Lenner; Göran Hallmans; Matti Lehtinen; Rudolf Kaaks; Göran Wadell; Anne Zeleniuch-Jacquotte; Eva Lundin; Annekatrin Lukanova
Therapeutics, Targets, and Chemical Biology
SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
John A. Hartley; Anzu Hamaguchi; Marissa Coffils; Christopher R.H. Martin; Marie Suggitt; Zhizhi Chen; Stephen J. Gregson; Luke A. Masterson; Arnaud C. Tiberghien; Janet M. Hartley; Christopher Pepper; Thet Thet Lin; Christopher Fegan; David E. Thurston; Philip W. Howard
MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor–Dependent Fashion to Suppress Carcinoma Growth
Yu-Wen Zhang; Ben Staal; Curt Essenburg; Yanli Su; Liang Kang; Rich West; Dafna Kaufman; Tom DeKoning; Bryn Eagleson; Sean G. Buchanan; George F. Vande Woude
Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases
Jennifer M. Atkinson; Robert A. Falconer; Dylan R. Edwards; Caroline J. Pennington; Catherine S. Siller; Steven D. Shnyder; Michael C. Bibby; Laurence H. Patterson; Paul M. Loadman; Jason H. Gill
Tumor and Stem Cell Biology
Voltage-Gated Na+ Channel SCN5A Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion
Carrie D. House; Charles J. Vaske; Arnold M. Schwartz; Vincent Obias; Bryan Frank; Truong Luu; Narine Sarvazyan; Rosalyn Irby; Robert L. Strausberg; Tim G. Hales; Joshua M. Stuart; Norman H. Lee
Matrix Metalloproteinase-9 Is Upregulated in Nucleophosmin-Anaplastic Lymphoma Kinase–Positive Anaplastic Lymphomas and Activated at the Cell Surface by the Chaperone Heat Shock Protein 90 to Promote Cell Invasion
Frédéric Lagarrigue; Sophie Dupuis-Coronas; Damien Ramel; Georges Delsol; Hélène Tronchère; Bernard Payrastre; Frédérique Gaits-Iacovoni
Letters to the Editor
Correction
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