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1 August 2010
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DNA damage induced by 6-thioguanine is repaired by homologous recombination. Cells treated with 6-thioguanine were fixed, and DNA (blue), RAD51 (red), and γH2AX (green) were visualized by immunofluorescence. RAD51 foci formed in V-C8+B2 cells and colocalized with γH2AX foci. For details, see the article by Helleday and colleagues on page 6268 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Review
Meeting Report
Integrated Systems and Technologies
A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens
Jing Sun; Michael D. Masterman-Smith; Nicholas A. Graham; Jing Jiao; Jack Mottahedeh; Dan R. Laks; Minori Ohashi; Jason DeJesus; Ken-ichiro Kamei; Ki-Bum Lee; Hao Wang; Zeta T.F. Yu; Yi-Tsung Lu; Shuang Hou; Keyu Li; Max Liu; Nangang Zhang; Shutao Wang; Brigitte Angenieux; Eduard Panosyan; Eric R. Samuels; Jun Park; Dirk Williams; Vera Konkankit; David Nathanson; R. Michael van Dam; Michael E. Phelps; Hong Wu; Linda M. Liau; Paul S. Mischel; Jorge A. Lazareff; Harley I. Kornblum; William H. Yong; Thomas G. Graeber; Hsian-Rong Tseng
Microenvironment and Immunology
Single-Cell Analysis of T-Cell Receptor Repertoire of HTLV-1 Tax-Specific Cytotoxic T Cells in Allogeneic Transplant Recipients with Adult T-Cell Leukemia/Lymphoma
Yukie Tanaka; Hideki Nakasone; Rie Yamazaki; Ken Sato; Miki Sato; Kiriko Terasako; Shun-ichi Kimura; Shinya Okuda; Shinichi Kako; Kumi Oshima; Aki Tanihara; Junji Nishida; Toshiaki Yoshikawa; Tetsuya Nakatsura; Haruo Sugiyama; Yoshinobu Kanda
Molecular and Cellular Pathobiology
The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease
Christine Dierks; Francisco Adrian; Paul Fisch; Hong Ma; Helga Maurer; Dieter Herchenbach; Christine Ulrike Forster; Clara Sprissler; Guoxun Liu; Sabine Rottmann; Gui-Rong Guo; Zirlik Katja; Hendrik Veelken; Markus Warmuth
Therapeutics, Targets, and Chemical Biology
6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
Natalia Issaeva; Huw D. Thomas; Tatjana Djurenovic; Janneke E. Jaspers; Ivaylo Stoimenov; Suzanne Kyle; Nicholas Pedley; Ponnari Gottipati; Rafal Zur; Kate Sleeth; Vicky Chatzakos; Evan A. Mulligan; Cecilia Lundin; Evgenia Gubanova; Ariena Kersbergen; Adrian L. Harris; Ricky A. Sharma; Sven Rottenberg; Nicola J. Curtin; Thomas Helleday
Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors
Elena V. Efimova; Helena J. Mauceri; Daniel W. Golden; Edwardine Labay; Vytautas P. Bindokas; Thomas E. Darga; Chaitali Chakraborty; Juan Camilo Barreto-Andrade; Clayton Crawley; Harold G. Sutton; Stephen J. Kron; Ralph R. Weichselbaum
Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling and Reduces Hypoxia in Tumors
Junpei Sasajima; Yusuke Mizukami; Yoshiaki Sugiyama; Kazumasa Nakamura; Toru Kawamoto; Kazuya Koizumi; Rie Fujii; Wataru Motomura; Kazuya Sato; Yasuaki Suzuki; Satoshi Tanno; Mikihiro Fujiya; Katsunori Sasaki; Norihiko Shimizu; Hidenori Karasaki; Toru Kono; Jun-ichi Kawabe; Masaaki Ii; Hiroki Yoshiara; Naohisa Kamiyama; Toshifumi Ashida; Nabeel Bardeesy; Daniel C. Chung; Yutaka Kohgo
Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway
Margaret A. Park; Clint Mitchell; Guo Zhang; Adly Yacoub; Jeremy Allegood; Dieter Häussinger; Roland Reinehr; Andrew Larner; Sarah Spiegel; Paul B. Fisher; Christina Voelkel-Johnson; Besim Ogretmen; Steven Grant; Paul Dent
Tumor and Stem Cell Biology
Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells
Kara Mitchell; Kimberly B. Svenson; Whitney M. Longmate; Katerina Gkirtzimanaki; Rafal Sadej; Xianhui Wang; Jihe Zhao; Aristides G. Eliopoulos; Fedor Berditchevski; C. Michael DiPersio
Letter to the Editor
Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track – Letter
Anja Torsvik; Gro V. Røsland; Agnete Svendsen; Anders Molven; Heike Immervoll; Emmet McCormack; Per Eystein Lønning; Monika Primon; Ewa Sobala; Joerg-Christian Tonn; Roland Goldbrunner; Christian Schichor; Josef Mysliwietz; Tamara T. Lah; Helena Motaln; Stian Knappskog; Rolf Bjerkvig
Corrections
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