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15 May 2010
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The poor prognosis of basal-like breast cancer (BLBC) reflects its uncertain molecular basis. In the present study, Ray and colleagues show that forkhead box (FOX) transcription factor C1 regulates the growth, migration, and invasion of BLBC cells. Microarray analyses revealed consistent and exclusive expression of FOXC1 in BLBC versus other molecular types of breast cancer. Significantly, FOXC1 expression in BLBC was inversely correlated with overall survival and with brain metastasis-free survival. In this figure, immunohistochemical staining demonstrates the nuclear localization of FOXC1 in estrogen receptor-negative breast cancer. For details, see the article by Ray and colleagues on page 3870 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Breaking Advances
Reviews
Meeting Report
Priority Reports
FOXC1 Is a Potential Prognostic Biomarker with Functional Significance in Basal-like Breast Cancer
Partha S. Ray; Jinhua Wang; Ying Qu; Myung-Shin Sim; Jaime Shamonki; Sanjay P. Bagaria; Xing Ye; Bingya Liu; David Elashoff; Dave S. Hoon; Michael A. Walter; John W. Martens; Andrea L. Richardson; Armando E. Giuliano; Xiaojiang Cui
Identification of the ENT1 Antagonists Dipyridamole and Dilazep as Amplifiers of Oncolytic Herpes Simplex Virus-1 Replication
Brent J. Passer; Tooba Cheema; Bingsen Zhou; Hiroaki Wakimoto; Cecile Zaupa; Mani Razmjoo; Jason Sarte; Shulin Wu; Chin-lee Wu; James W. Noah; Qianjun Li; John K. Buolamwini; Yun Yen; Samuel D. Rabkin; Robert L. Martuza
Integrated Systems and Technologies
Microenvironment and Immunology
4-1BB Ligand as an Effective Multifunctional Immunomodulator and Antigen Delivery Vehicle for the Development of Therapeutic Cancer Vaccines
Rajesh K. Sharma; Rich-Henry Schabowsky; Abhishek K. Srivastava; Kutlu G. Elpek; Shravan Madireddi; Hong Zhao; Zhenping Zhong; Robert W. Miller; Kathryn J. MacLeod; Esma S. Yolcu; Haval Shirwan
Molecular and Cellular Pathobiology
Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro
Dave N.T. Aryee; Stephan Niedan; Maximilian Kauer; Raphaela Schwentner; Idriss M. Bennani-Baiti; Jozef Ban; Karin Muehlbacher; Michael Kreppel; Robert L. Walker; Paul Meltzer; Christopher Poremba; Reinhard Kofler; Heinrich Kovar
Involvement of the Tubulin Tyrosine Ligase-Like Family Member 4 Polyglutamylase in PELP1 Polyglutamylation and Chromatin Remodeling in Pancreatic Cancer Cells
Kotoe Kashiwaya; Hidewaki Nakagawa; Masayo Hosokawa; Yasuo Mochizuki; Koji Ueda; Lianhua Piao; Suyoun Chung; Ryuji Hamamoto; Hidetoshi Eguchi; Hiroaki Ohigashi; Osamu Ishikawa; Carsten Janke; Yasuhisa Shinomura; Yusuke Nakamura
Therapeutics, Targets, and Chemical Biology
Preclinical Evaluation of an 131I-Labeled Benzamide for Targeted Radiotherapy of Metastatic Melanoma
John L. Joyal; John A. Barrett; John C. Marquis; Jianqing Chen; Shawn M. Hillier; Kevin P. Maresca; Marie Boyd; Kenneth Gage; Sridhar Nimmagadda; James F. Kronauge; Matthias Friebe; Ludger Dinkelborg; James B. Stubbs; Michael G. Stabin; Rob Mairs; Martin G. Pomper; John W. Babich
Tumor and Stem Cell Biology
Extranuclear Functions of ER Impact Invasive Migration and Metastasis by Breast Cancer Cells
Dimple Chakravarty; Sujit S. Nair; Bindu Santhamma; Binoj C. Nair; Long Wang; Abhik Bandyopadhyay; Joseph K. Agyin; Darrell Brann; Lu-Zhe Sun; I-Tien Yeh; Francis Y. Lee; Rajeshwar Rao Tekmal; Rakesh Kumar; Ratna K. Vadlamudi
Role of H2O2 in RET/PTC1 Chromosomal Rearrangement Produced by Ionizing Radiation in Human Thyroid Cells
Rabii Ameziane-El-Hassani; Myriem Boufraqech; Odile Lagente-Chevallier; Urbain Weyemi; Monique Talbot; Didier Métivier; Françoise Courtin; Jean-Michel Bidart; Mohammed El Mzibri; Martin Schlumberger; Corinne Dupuy
Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging
Keizo Takeshita; Kumiko Kawaguchi; Kaori Fujii-Aikawa; Megumi Ueno; Shoko Okazaki; Mitsuhiro Ono; Murali C. Krishna; Periannan Kuppusamy; Toshihiko Ozawa; Nobuo Ikota
Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
Shinya Ohashi; Mitsuteru Natsuizaka; Gabrielle S. Wong; Carmen Z. Michaylira; Katharine D. Grugan; Douglas B. Stairs; Jiri Kalabis; Maria E. Vega; Ross A. Kalman; Momo Nakagawa; Andres J. Klein-Szanto; Meenhard Herlyn; J. Alan Diehl; Anil K. Rustgi; Hiroshi Nakagawa
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