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1 February 2009
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One of the visionary ideas of the late Dr. Judah Folkman was to treat cancer based on discovery of ultra-early biomarkers long before tumors become symptomatic or determination of their anatomical location is feasible. This idea was based on the hypothesis that most tumors remain dormant as microscopic lesions for a long period of time, until they gain the ability to recruit vessels in a process called tumor angiogenesis. Dormant tumors that switch to the angiogenic phenotype grow exponentially and ultimately become clinically apparent, which is referred to as the disease state of cancer. A major limitation in investigating the tumor dormancy process is the lack of suitable experimental models and the limited clinical accessibility of dormant tumors. In this report, Almog and colleagues identified the molecular determinants of tumor dormancy by characterizing the consensus transcriptome signature of dormant versus fast-growing experimental human osteosarcoma, liposarcoma, breast carcinoma, and glioblastoma multiforme tumor models. Differential regulation and activation of several signaling pathways not previously associated with the dormancy process are also reported and validated based on protein expression and activation levels. The molecular signature of tumor dormancy was further used to test the feasibility of selected proteins as blood (plasma)-based biomarkers in mice and in human specimens. The enhanced sensitivity of dormant tumors to angiostatin, compared with that of fast-growing angiogenic tumors, was correlated with selective uptake of angiostatin (green) in angiomotin (red)-positive dormant osteosarcoma cells (blue, cell nucleus). This work may provide molecular instructions for discovery of ultra-early tumor biomarkers and possible therapeutic targets for the blockage of early tumor development. For details, see the article by Almog and colleagues on page 836 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
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Seung-Woo Hong; Chang-Jae Kim; Won-Sang Park; Jae-Sik Shin; Soon-Duck Lee; Seong-Gyu Ko; Sam-Il Jung; In-Chul Park; Sung-Kwan An; Won-Keun Lee; Wang-Jae Lee; Dong-Hoon Jin; Myeong-Sok Lee
Faciogenital Dysplasia Protein Fgd1 Regulates Invadopodia Biogenesis and Extracellular Matrix Degradation and Is Up-regulated in Prostate and Breast Cancer
Inmaculada Ayala; Giada Giacchetti; Giusi Caldieri; Francesca Attanasio; Stefania Mariggiò; Stefano Tetè; Roman Polishchuk; Vincent Castronovo; Roberto Buccione
Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome
J. Keith Killian; Sven Bilke; Sean Davis; Robert L. Walker; M. Scott Killian; Erich B. Jaeger; Yidong Chen; Jason Hipp; Stefania Pittaluga; Mark Raffeld; Robert Cornelison; William I. Smith,, Jr.; Marina Bibikova; Jian-Bing Fan; Michael R. Emmert-Buck; Elaine S. Jaffe; Paul S. Meltzer
Cell, Tumor, and Stem Cell Biology
Antitumor Effects of a Combined 5-Aza-2′Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in Ptch Mutant Mice
Ines Ecke; Frauke Petry; Albert Rosenberger; Svantje Tauber; Sven Mönkemeyer; Ina Hess; Christian Dullin; Sarah Kimmina; Judith Pirngruber; Steven A. Johnsen; Anja Uhmann; Frauke Nitzki; Leszek Wojnowski; Walter Schulz-Schaeffer; Olaf Witt; Heidi Hahn
Endocrinology
Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma: Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors
Ryuichiro Sato; Takashi Suzuki; Yu Katayose; Koh Miura; Kenichi Shiiba; Hiroo Tateno; Yasuhiro Miki; Junichi Akahira; Yukiko Kamogawa; Shuji Nagasaki; Kuniharu Yamamoto; Takayuki Ii; Shinichi Egawa; Dean B. Evans; Michiaki Unno; Hironobu Sasano
Epidemiology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Limits to Thymidylate Synthase and TP53 Genes as Predictive Determinants for Fluoropyrimidine Sensitivity and Further Evidence for RNA-Based Toxicity as a Major Influence
Jonathan R. Brody; Tomas Hucl; Christina L. Costantino; James R. Eshleman; Eike Gallmeier; Heng Zhu; Michiel S. van der Heijden; Jordan M. Winter; Agnieszka K. Wikiewicz; Charles J. Yeo; Scott E. Kern
Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RARα and PML-RARα
Maurizio Gianni'; Andrea Boldetti; Valeria Guarnaccia; Alessandro Rambaldi; Edoardo Parrella; Ivan Raska, Jr.; Cecile Rochette-Egly; Giannino Del Sal; Alessandra Rustighi; Mineko Terao; Enrico Garattini
Immunology
A Long, Naturally Presented Immunodominant Epitope from NY-ESO-1 Tumor Antigen: Implications for Cancer Vaccine Design
Lisa M. Ebert; Yu Chih Liu; Craig S. Clements; Neil C. Robson; Heather M. Jackson; Jessica L. Markby; Nektaria Dimopoulos; Bee Shin Tan; Immanuel F. Luescher; Ian D. Davis; Jamie Rossjohn; Jonathan Cebon; Anthony W. Purcell; Weisan Chen
Molecular Biology, Pathobiology, and Genetics
Prediction of Clinical Outcome in Multiple Lung Cancer Cohorts by Integrative Genomics: Implications for Chemotherapy Selection
Philippe Broët; Sophie Camilleri-Broët; Shenli Zhang; Marco Alifano; Dhinoth Bangarusamy; Maxime Battistella; Yonghui Wu; Marianne Tuefferd; Jean-François Régnard; Elaine Lim; Patrick Tan; Lance D. Miller
IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor–Initiated Apoptosis via Repression of FLICE-like Protein Expression
Dafeng Yang; Suizhao Wang; Craig Brooks; Zheng Dong; Patricia V. Schoenlein; Vijay Kumar; Xinshou Ouyang; Huabao Xiong; Guy Lahat; Andrea Hayes-Jordan; Alexander Lazar; Raphael Pollock; Dina Lev; Kebin Liu
Akt Activation Synergizes with Trp53 Loss in Oral Epithelium to Produce a Novel Mouse Model for Head and Neck Squamous Cell Carcinoma
Marta Moral; Carmen Segrelles; M. Fernanda Lara; Ana Belén Martínez-Cruz; Corina Lorz; Mirentxu Santos; Ramón García-Escudero; Jerry Lu; Kaoru Kiguchi; Agueda Buitrago; Clotilde Costa; Cristina Saiz; Jose L. Rodriguez-Peralto; Francisco J. Martinez-Tello; Maria Rodriguez-Pinilla; Montserrat Sanchez-Cespedes; Marina Garín; Teresa Grande; Ana Bravo; John DiGiovanni; Jesús M. Paramio
Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias
Zejuan Li; Roger T. Luo; Shuangli Mi; Miao Sun; Ping Chen; Jingyue Bao; Mary Beth Neilly; Nimanthi Jayathilaka; Deborah S. Johnson; Lili Wang; Catherine Lavau; Yanming Zhang; Charles Tseng; Xiuqing Zhang; Jian Wang; Jun Yu; Huanming Yang; San Ming Wang; Janet D. Rowley; Jianjun Chen; Michael J. Thirman
Distinct Roles of BARD1 Isoforms in Mitosis: Full-Length BARD1 Mediates Aurora B Degradation, Cancer-Associated BARD1β Scaffolds Aurora B and BRCA2
Stephan Ryser; Eva Dizin; Charles Edward Jefford; Bénédicte Delaval; Sarantis Gagos; Agni Christodoulidou; Karl-Heinz Krause; Daniel Birnbaum; Irmgard Irminger-Finger
Prevention
Systems Biology and Emerging Technologies
Tumor Microenvironment
Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism
Balveen Kaur; Sarah M. Cork; Eric M. Sandberg; Narra S. Devi; Zhaobin Zhang; Philip A. Klenotic; Maria Febbraio; Hyunsuk Shim; Hui Mao; Carol Tucker-Burden; Roy L. Silverstein; Daniel J. Brat; Jeffrey J. Olson; Erwin G. Van Meir
Letters to the Editor
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